Segluromet vs. Synjardy for Diabetes Type 2: Important Differences and Potential Risks.

Segluromet

(ertugliflozin / metformin)

Synjardy

Summary for Segluromet

Prescription only

Segluromet is a medication that combines two ingredients: ertugliflozin (a sodium glucose cotransporter 2 inhibitor) and metformin (a biguanide). It helps lower blood sugar levels in adults with Type 2 diabetes. Segluromet works best when you also follow a diabetes-friendly diet and exercise regularly. This medication comes as a tablet that's taken by mouth twice a day with food. Side effects can include diarrhea, stomach upset, and genital yeast infections. Segluromet is only available as a brand-name medication.

Indications for Segluromet

Type 2 diabetes

Pros and Cons for Segluromet

Pros

Two diabetes medications combined into one tablet so there's less pills to take each day
Adjustable dose based on blood sugar levels

Cons

Might make you urinate more
Not for people with Type 1 diabetes
Not recommended during pregnancy or while breastfeeding

Common Side Effects for Segluromet

Side effects from ertugliflozin:

Genital fungal infection
Urinary tract infection
Headache

Side effects from metformin:

Diarrhea
Nausea
Vomiting
Passing gas
Stomach discomfort
Indigestion
Weakness
Headache

Warnings for Segluromet

Lactic acidosis
Serious genital infections and urinary tract infections
Low fluids in the body (leading to low blood pressure, dehydration, or kidney problems)
Ketoacidosis
Leg and foot amputations
Low blood sugar (hypoglycemia) when taken with certain diabetes medications
Low vitamin B12 levels

Summary for Synjardy

Prescription only

Synjardy is a tablet containing empagliflozin (an SGLT2 inhibitor) and metformin (a biguanide). It helps lower blood sugar in people with Type 2 diabetes when used with a balanced diet and regular exercise. Synjardy can also help lower the risk of serious problems in adults with Type 2 diabetes who have heart disease, heart failure, or chronic kidney disease (CKD). Immediate-release tablets (IR) are for people 10 years and older and are taken twice a day. The extended-release tablets (XR) are only for adults and are taken once a day. Side effects include urinary tract infections and genital yeast infections.

Indications for Synjardy

Type 2 diabetes
Lowering the risk of death due to heart problems in adults with Type 2 diabetes and heart disease
Lowering the risk of hospitalization and death due to heart problems in adults with Type 2 diabetes and heart failure
Lowering the risk of worsening kidney problems, hospitalization, and death due to heart problems in adults with Type 2 diabetes and chronic kidney disease (CKD)

Pros and Cons for Synjardy

Pros

Combines two medications into one tablet for convenience
Not likely to cause weight gain
Available in both immediate-release and extended-release versions
Immediate-release tablets are okay for children 10 years and older to take

Cons

Need to take with food
Might cause urinary tract infections or genital yeast infections
Not safe for people with severe kidney problems or on dialysis
Not approved for people with Type 1 diabetes

Common Side Effects for Synjardy

Low blood sugar (up to 16%)
Urinary tract infection (up to 9%)
Upper respiratory tract infection or common cold (up to 8%)

Note: Side effect percentages were reported by adults taking empagliflozin, metformin, and a sulfonylurea.

Warnings for Synjardy

Lactic acidosis
Ketoacidosis
Low fluids in the body (leading to low blood pressure, dehydration, or kidney problems)
Genital infections and urinary tract infections
Low blood sugar (hypoglycemia) when taken with certain diabetes medications
Leg and foot amputations
Serious allergic reaction
Low vitamin B12 levels