Lincomycin vs. Clindamycin for Bacterial Infection: Important Differences and Potential Risks.

Lincomycin

(Lincocin)

Clindamycin

(Cleocin)

Summary for Lincomycin

Prescription only

Lincomycin, also known by the brand name, Lincocin, is a lincosamide antibiotic used to treat serious infections caused by certain bacteria, especially in people who are allergic to penicillin. The medication is injected into a muscle (IM) or through a vein (IV), and can also be injected into the eye for certain eye infections. Lincomycin (Lincocin) can be given once per day, but severe infections might require more frequent doses. Side effects include diarrhea (including C. diff diarrhea), nausea, and stomach pain.

Indications for Lincomycin

Treatment of serious bacterial infections in people who are allergic to penicillin

Pros and Cons for Lincomycin

Pros

Can treat many different infections throughout the body
Can use in children as young as 1 month old
An option for people with penicillin allergy

Cons

Only available as an injection
Need to receive multiple times per day for more severe infections
Causes diarrhea more frequently than other antibiotics

Common Side Effects for Lincomycin

Diarrhea
Nausea
Vomiting
Stomach pain
Rash
Hives
Dizziness

Warnings for Lincomycin

Diarrhea from Clostridioides difficile infection
Severe allergic reactions and skin reactions
Risk of gasping syndrome

Summary for Clindamycin

Prescription only

Clindamycin (Cleocin) is a lincosamide antibiotic that's used to treat many different serious bacterial infections, such as strep throat and skin infections. This antibiotic is approved for use in both adults and children. Clindamycin (Cleocin) is available as a capsule and liquid that are taken 3 or 4 times per day, depending on your age and your infection. It's also available as an injection that's given by a healthcare professional. Side effects include stomach upset, itching, and rash.

Indications for Clindamycin

Skin infections (e.g., cellulitis)
Lower respiratory tract infections (e.g., pneumonia, bronchitis)
Stomach infections
Pelvic and genital tract infections
Bloodstream infections
Bone and joint infections - injection form only

Pros and Cons for Clindamycin

Pros

Can treat many different infections throughout the body
Available as lower-cost generic capsule, liquid, and injection
Can take if you have a penicillin allergy

Cons

Might need to take three or four times per day
Must take capsules with a full glass of water to prevent irritation to your esophagus (the tube that connects your throat to your stomach)
Risk of causing a type of infectious diarrhea