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Ingrezza vs. Austedo

Ingrezza (valbenazine) is a VMAT2 inhibitor that treats tardive dyskinesia (TD) in adults. It can also treat chorea (random muscle movements) in adults with Huntington's disease. Ingrezza (valbenazine) is available as a capsule and the dose is taken by mouth once a day. But this medication can have side effects, like sleepiness and other movement problems (e.g., parkinsonism).

• Tardive dyskinesia (TD) in adults
• Chorea (random muscle movements) in adults with Huntington's disease

Tardive dyskinesia:

• Sleepiness (11%)
• Dry mouth (5%)
• Constipation (5%)
• Blurry vision (5%)
• Trouble urinating (5%)

Chorea from Huntington's disease:

• Sleepiness (19%)
• Fatigue (14%)
• Hives (9%)
• Rash (8%)
• Can't stay still (6%)
• Trouble sleeping (6%)
• Diarrhea (5%)
• Nausea (5%)
• Depression (5%)
• Back pain (5%)

• Risk of depression and suicidal thoughts and behavior
• Allergic reactions
• Sleepiness
• Life-threatening abnormal heart rhythm (QT prolongation)
• Neuroleptic malignant syndrome
• Abnormal movements (parkinsonism)

Austedo (deutetrabenazine) treats chorea in adults with Huntington's disease. It also treats tardive dyskinesia in adults. It works as a vesicular monoamine transporter 2 (VMAT2) inhibitor to help control body movements. Austedo (deutetrabenazine) comes as a tablet you take by mouth. The immediate-release version (Austedo) is taken twice a day, and the extended-release version (Austedo XR) is taken once a day. You start at a low dose, and then your prescriber slowly raises it over a few weeks. Austedo XR has a 4-week titration pack to help with this. Side effects include sleepiness, diarrhea, and dry mouth. As of mid-2025, it's only as a brand-name version; there's no generic yet.

• Chorea (uncontrolled movements) in adults with Huntington's disease
• Tardive dyskinesia in adults

Chorea from Huntington's disease:

• Sleepiness (11%)
• Diarrhea (9%)
• Dry mouth (9%)
• Tiredness (9%)
• Urinary tract infection or UTI (7%)
• Trouble sleeping (7%)

Tardive dyskinesia:

• Runny nose, sore throat, or other symptoms of the common cold (4%)
• Trouble sleeping (4%)

• Risk of depression and suicidal thoughts in people with Huntington's disease
• Worsening of symptoms in people with Huntington's disease
• Possible changes in heart rhythm (QT prolongation)
• Possible risk of neuroleptic malignant syndrome (NMS)
• Restlessness and other movement problems like parkinsonism
• High prolactin levels