Compare Imbruvica vs. Brukinsa
Head-to-head comparisons of medication uses, side effects, warnings, and more.
- Imbruvica (ibrutinib)Brukinsa (zanubrutinib)
- Imbruvica (ibrutinib)Brukinsa (zanubrutinib)
Summary of Imbruvica vs. Brukinsa
Summary for Kinase inhibitorPrescription onlyImbruvica (ibrutinib) is an oral cancer medication used for certain leukemias, blood cancers, and blood cell conditions. It commonly causes diarrhea, tiredness, and easy bruising.
Summary for Bruton’s tyrosine kinase (BTK) inhibitorPrescription onlyBrukinsa (zanubrutinib) is targeted therapy called Bruton’s tyrosine kinase (BTK) inhibitor. It’s used to treat certain blood cancers (leukemia), such as mantle cell lymphoma (MCL) and chronic lymphocytic leukemia (CLL). It’s convenient because it’s a capsule that you take by mouth either once or twice a day. But Brukinsa (zanubrutinib) can cause side effects such as higher blood sugar levels, infections, and muscle pain. It's best to avoid drinking alcohol if you're taking Brukinsa (zanubrutinib).
Indications of Imbruvica vs. Brukinsa
Indications for•Waldenström's macroglobulinemia (WM) in adults•Chronic graft versus host disease (cGVHD) in adults and children 1 year and olderIndications for•Mantle cell lymphoma (MCL) after at least one prior therapy•Advanced marginal zone lymphoma (MZL) for people who didn’t respond well to other anticancer medications•Advanced follicular lymphoma (FL)Pros and Cons of Imbruvica vs. Brukinsa
Pros and Const for Kinase inhibitorPros•Oral medication•Once-daily dosing•One of the first-choice treatment options for CLL•Safe to use in people with mild kidney problems; no dose adjustments neededCons•Raises your risk for infections and serious bleeding events•Must use birth control while taking, as it can harm an unborn baby•Not a good option in people with severe liver problems•Available as brand only, so it can be expensivePros and Const for Bruton’s tyrosine kinase (BTK) inhibitorPros•Can be taken with or without food•Flexible dosing with option to take dose once or twice a day•More precise in the way it targets cancer cells, compared to traditional chemotherapyCons•Will need regularly blood test done to check blood cell count•Can commonly cause muscle and joint pain, bleeds, and infections•Must use birth control while taking, as it can harm an unborn babyCommon Side Effects of Imbruvica vs. Brukinsa
Common Side Effects for•Fatigue (Up to 80%)•Low white blood cells (neutropenia), (Up to 66%)•Bone or muscle pain (Up to 61%)•Diarrhea (Up to 59%)•Bruising (Up to 51%)•Rash (Up to 49%)•Upper respiratory tract infection (Up to 47%)•High blood pressure (Up to 42%)•Joint pain (Up to 41%)•Nausea (Up to 40%)•Headache (Up to 40%)•Low platelet count (thrombocytopenia), (Up to 36%)•Cough (Up to 32%)•Bleeding (Up to 32%)•Fever (Up to 30%)•Mouth sores (Up to 29%)•Muscle spasms (Up to 29%)•Swelling in the body (Up to 28%)•Infusion reactions (Up to 25%)•Pneumonia (Up to 23%)•Stomach pain (Up to 23%)•Constipation (Up to 22%)•Dizziness (Up to 21%)•Vomiting (Up to 19%)•Skin infection (Up to 18%)•Low red blood cells (anemia), (Up to 17%)Common Side Effects for•Higher blood sugar levels (55%)•Low blood cell counts, all (up to 50%)•Muscle or joint pain (up to 45%)•Cough, runny nose, and other symptoms of an upper respiratory tract infection (up to 44%)•Bleeding (up to 42%)•Rash (up to 36%)•Higher creatinine levels (34%)•Tiredness (up to 31%)•Higher liver enzyme levels (up to 28%)•Changes in electrolyte levels (up to 27%)•Diarrhea (up to 25%)•Higher potassium levels (24%)•Bruising (up to 24%)Warnings of Imbruvica vs. Brukinsa
Common Side Effects for•Bleeding•Infections•Heart problems•High blood pressure•Risk of developing other cancers•Tumor lysis syndromeCommon Side Effects for•Serious infections•Serious bleeds•Low blood cell counts•Possible risk of cancers•Heart rhythm problems•Liver problems•Harm to an unborn babyPrices with our coupons for Imbruvica vs. Brukinsa
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