Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Cyclobenzaprine (Flexeril) and alprazolam (Xanax) are both medications that can help with certain conditions, but they belong to different drug classes and have different uses. Cyclobenzaprine is a muscle relaxant used to treat muscle pain and discomfort, while alprazolam is a benzodiazepine used to treat generalized anxiety disorder (GAD) and panic disorder. Cyclobenzaprine is available as immediate-release tablets and extended-release capsules, and it is not a controlled substance. Alprazolam, on the other hand, is a Schedule IV controlled medication and comes in immediate-release tablets, orally disintegrating tablets, and oral solution forms. Cyclobenzaprine can cause drowsiness and dry mouth, and it should not be mixed with alcohol due to increased drowsiness. Alprazolam can also cause drowsiness and memory problems, and it carries a risk of dependence and withdrawal symptoms if stopped suddenly. Cyclobenzaprine is typically used for short-term treatment (up to 2 to 3 weeks). Alprazolam is also meant for short-term use to avoid dependence. Both medications should be used with caution, especially if you are taking other medications that cause drowsiness or if you have liver problems.
Cyclobenzaprine
Alprazolam (Xanax)
Cyclobenzaprine
Alprazolam (Xanax)
Summary of Flexeril vs. Xanax
Summary for Muscle relaxant
Prescription only
Cyclobenzaprine is a muscle relaxant used in addition to rest and physical therapy to treat muscle pain and discomfort. It's available as an immediate-release (IR) tablet and an extended-release (ER) capsule. Unlike other muscle relaxants, it's not considered a controlled substance. Cyclobenzaprine can make you sleepy as a side effect so it's best to avoid alcohol to prevent serious harm from combining the two together.