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Compare Eliglustat vs. Imiglucerase

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Cerdelga (eliglustat)
    Cerezyme (imiglucerase)
  • Cerdelga (eliglustat)
    Cerezyme (imiglucerase)

  • Summary of Eliglustat vs. Imiglucerase

    Summary for Glucosylceramide synthase inhibitor
    Prescription only

    Cerdelga (eliglustat) is a medication that belongs to a drug class known as glucosylceramide synthase inhibitors. This medication is FDA-approved as long-term treatment for certain adults with a rare genetic condition called Gaucher disease type 1 (GD1). Cerdelga (eliglustat) is a capsule that's taken by mouth. Side effects can include fatigue, headache, and nausea.

    Summary for Hydrolytic lysosomal glucocerebrosidase-specific enzyme
    Prescription only

    Cerezyme (imiglucerase) is a form of enzyme replacement therapy (ERT) used to treat Type 1 Gaucher disease in adults and children 2 years of age or older. It's given as an intravenous (IV) infusion by a healthcare provider. Overall, Cerezyme (imiglucerase) is well tolerated, but it can cause allergic or infusion-related reactions like hives or difficulty breathing.

  • Indications of Eliglustat vs. Imiglucerase

    Indications for
    •Gaucher disease type 1 (GD1) in certain adults
    Indications for
    •Type 1 Gaucher disease in adults and children 2 years of age or older

  • Pros and Cons of Eliglustat vs. Imiglucerase

    Pros and Const for Glucosylceramide synthase inhibitor
    Pros
    •First-choice treatment option in most adults with GD1
    •Can take with or without food
    •Taken by mouth, so it doesn’t require an IV or port like enzyme replacement therapy (ERT)
    •More convenient than ERT since you don't need frequent trips to the infusion center
    Cons
    •Requires genetic testing before you start treatment
    •Has many drug interactions (such as with certain antidepressants, antibiotics, and anti-seizure medications)
    •Might not be able to use if you have certain liver, kidney, or heart problems because of the risk for serious side effects
    •Not for use in children because it hasn’t been studied
    Pros and Const for Hydrolytic lysosomal glucocerebrosidase-specific enzyme
    Pros
    •Can be used long-term, for at least 20 years, to treat Type 1 Gaucher disease
    •Can be used in children as young as 2 years of age
    •Safe to use if pregnant or breastfeeding
    •Fewer side effects compared to oral medications for Gaucher disease type 1
    Cons
    •Might require frequent trips to the infusion center to receive treatment
    •Takes 1 to 2 hours to receive each infusion
    •Potential for allergic or infusion reactions with long-term use
    •Requires IV access, so it's not as convenient as taking a pill

  • Common Side Effects of Eliglustat vs. Imiglucerase

    Common Side Effects for
    •Fatigue (14%)
    •Headache (13%)
    •Nausea (12%)
    •Diarrhea (12%)
    •Back pain (12%)
    •Pain in arm or leg (11%)
    •Upper stomach pain (10%)
    Common Side Effects for
    •Itching
    •Fever
    •Rash
    •Chills
    •Chest discomfort

  • Warnings of Eliglustat vs. Imiglucerase

    Common Side Effects for
    •Heart rhythm problems
    Common Side Effects for
    •Allergic or infusion-related reactions

  • Prices with our coupons for Eliglustat vs. Imiglucerase

    Learn more about Cerdelga
    Learn more about Cerezyme

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