Eliglustat vs. Imiglucerase for Inherited Metabolic Diseases and Lysosomal Storage Disease: Important Differences and Potential Risks.

Cerdelga

(eliglustat)

Cerezyme

(imiglucerase)

Summary for Eliglustat

Prescription only

Cerdelga (eliglustat) is a medication that belongs to a drug class known as glucosylceramide synthase inhibitors. This medication is FDA-approved as long-term treatment for certain adults with a rare genetic condition called Gaucher disease type 1 (GD1). Cerdelga (eliglustat) is a capsule that's taken by mouth. Side effects can include fatigue, headache, and nausea.

Indications for Eliglustat

Gaucher disease type 1 (GD1) in certain adults

Pros and Cons for Eliglustat

Pros

First-choice treatment option in most adults with GD1
Can take with or without food
Taken by mouth, so it doesn’t require an IV or port like enzyme replacement therapy (ERT)
More convenient than ERT since you don't need frequent trips to the infusion center

Cons

Requires genetic testing before you start treatment
Has many drug interactions (such as with certain antidepressants, antibiotics, and anti-seizure medications)
Might not be able to use if you have certain liver, kidney, or heart problems because of the risk for serious side effects
Not for use in children because it hasn’t been studied

Common Side Effects for Eliglustat

Fatigue (14%)
Headache (13%)
Nausea (12%)
Diarrhea (12%)
Back pain (12%)
Pain in arm or leg (11%)
Upper stomach pain (10%)

Warnings for Eliglustat

Heart rhythm problems

Summary for Imiglucerase

Prescription only

Cerezyme (imiglucerase) is a form of enzyme replacement therapy (ERT) used to treat Type 1 Gaucher disease in adults and children 2 years of age or older. It's given as an intravenous (IV) infusion by a healthcare provider. Overall, Cerezyme (imiglucerase) is well tolerated, but it can cause allergic or infusion-related reactions like hives or difficulty breathing.

Indications for Imiglucerase

Type 1 Gaucher disease in adults and children 2 years of age or older

Pros and Cons for Imiglucerase

Pros

Can be used long-term, for at least 20 years, to treat Type 1 Gaucher disease
Can be used in children as young as 2 years of age
Safe to use if pregnant or breastfeeding
Fewer side effects compared to oral medications for Gaucher disease type 1

Cons

Might require frequent trips to the infusion center to receive treatment
Takes 1 to 2 hours to receive each infusion
Potential for allergic or infusion reactions with long-term use
Requires IV access, so it's not as convenient as taking a pill

Common Side Effects for Imiglucerase

Itching
Fever
Rash
Chills
Chest discomfort

Warnings for Imiglucerase

Allergic or infusion-related reactions

Prices with our coupons for Eliglustat vs. Imiglucerase

Cerdelga56 capsules / 84mg

$36,455.65-

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Cerezyme18 vials / 400 units

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Eliglustat vs. Imiglucerase

Cerdelga

Cerezyme

Summary for Eliglustat

Indications for Eliglustat

Pros and Cons for Eliglustat

Pros

Cons

Common Side Effects for Eliglustat

Warnings for Eliglustat

Summary for Imiglucerase

Indications for Imiglucerase

Pros and Cons for Imiglucerase

Pros

Cons

Common Side Effects for Imiglucerase

Warnings for Imiglucerase

Prices with our coupons for Eliglustat vs. Imiglucerase

Browse medications by letter

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Cerdelga

Cerezyme

Summary for Eliglustat

Indications for Eliglustat

Pros and Cons for Eliglustat

Pros

Cons

Common Side Effects for Eliglustat

Warnings for Eliglustat

Summary for Imiglucerase

Indications for Imiglucerase

Pros and Cons for Imiglucerase

Pros

Cons

Common Side Effects for Imiglucerase

Warnings for Imiglucerase