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Compare Cevimeline vs. Pilocarpine

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Cevimeline (Evoxac)
    Pilocarpine (Salagen)
  • Cevimeline (Evoxac)
    Pilocarpine (Salagen)

  • Summary of Cevimeline vs. Pilocarpine

    Summary for Cholinergic agonist
    Prescription only

    Cevimeline, also known by its brand name, Evoxac, is a prescription cholinergic agonist used to treat dry mouth (xerostomia) in adults with Sjögren's syndrome. It's available as both brand-name and generic capsules, with a typical dose of 30 mg taken by mouth three times per day. The most common side effects are excessive sweating, nausea, and headache.

    Summary for Cholinergic agonist
    Prescription only

    Pilocarpine (Salagen) is a cholinergic agonist that's used to help certain adults with dry mouth. It's a tablet that's taken by mouth 3 to 4 times per day. Side effects can include sweating, nausea, and runny nose. It's important to tell your provider and pharmacist about your medical history and your other medications because pilocarpine (Salagen) can sometimes worsen certain medical conditions and interact with many different medications.

  • Indications of Cevimeline vs. Pilocarpine

    Indications for
    •Dry mouth due to Sjögren's syndrome
    Indications for
    •Dry mouth due to radiation therapy for head and neck cancer
    •Dry mouth due to Sjögren's syndrome

  • Pros and Cons of Cevimeline vs. Pilocarpine

    Pros and Const for Cholinergic agonist
    Pros
    •FDA approved to treat dry mouth from Sjögren's syndrome
    •Available as a lower-cost generic
    •Might have less side effects than alternative pilocarpine (Salagen)
    Cons
    •Can affect your vision and make it harder to see, especially at night
    •Need to take a dose three times per day
    •Interacts with a lot of medications
    Pros and Const for Cholinergic agonist
    Pros
    •Works well to help with dry mouth
    •Can start to work quickly (about 20 minutes)
    •Available as a lower-cost, generic medication
    Cons
    •Need to take 3 or 4 times a day
    •Can take several weeks to get the most benefit from the medication
    •Can have a lot of side effects since the medication can reach and affect many parts of your body

  • Common Side Effects of Cevimeline vs. Pilocarpine

    Common Side Effects for
    •Sweating (19%)
    •Headache (14%)
    •Nausea (14%)
    •Sinus inflammation (12%)
    •Runny nose (11%)
    •Diarrhea (10%)
    •Stomach discomfort and pain (8%)
    •Urinary tract infection (6%)
    •Coughing (6%)
    •Vomiting (5%)
    Common Side Effects for

    Treatment of dry mouth from radiation:

    •Sweating (up to 68%)
    •Nausea (up to 15%)
    •Chills (up to 15%)
    •Runny nose (up to 14%)
    •Flushing (up to 13%)
    •Frequent urination (up to 12%)
    •Weakness (up to 12%)
    •Dizziness (up to 12%)

    Treatment of dry mouth from Sjögren's syndrome:

    •Sweating (40%)
    •Frequent urination (10%)
    •Flushing (9%)
    •Chills (4%)

  • Warnings of Cevimeline vs. Pilocarpine

    Common Side Effects for
    •Worsening heart problems
    •Worsening lung problems
    •Vision changes
    •Gallstones or kidney stones
    Common Side Effects for
    •Possible worsening of medical conditions
    •Vision changes
    •Dose too high

  • Prices with our coupons for Cevimeline vs. Pilocarpine

    Learn more about Cevimeline
    Learn more about Pilocarpine

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