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Cevimeline vs. Pilocarpine

Cevimeline, also known by its brand name, Evoxac, is a prescription cholinergic agonist used to treat dry mouth (xerostomia) in adults with Sjögren's syndrome. It's available as both brand-name and generic capsules, with a typical dose of 30 mg taken by mouth three times per day. The most common side effects are excessive sweating, nausea, and headache.

• Dry mouth due to Sjögren's syndrome

• Sweating (19%)
• Headache (14%)
• Nausea (14%)
• Sinus inflammation (12%)
• Runny nose (11%)
• Diarrhea (10%)
• Stomach discomfort and pain (8%)
• Urinary tract infection (6%)
• Coughing (6%)
• Vomiting (5%)

• Worsening heart problems
• Worsening lung problems
• Vision changes
• Gallstones or kidney stones

Pilocarpine (Salagen) is a cholinergic agonist that's used to help certain adults with dry mouth. It's a tablet that's taken by mouth 3 to 4 times per day. Side effects can include sweating, nausea, and runny nose. It's important to tell your provider and pharmacist about your medical history and your other medications because pilocarpine (Salagen) can sometimes worsen certain medical conditions and interact with many different medications.

• Dry mouth due to radiation therapy for head and neck cancer
• Dry mouth due to Sjögren's syndrome

Treatment of dry mouth from radiation:

• Sweating (up to 68%)
• Nausea (up to 15%)
• Chills (up to 15%)
• Runny nose (up to 14%)
• Flushing (up to 13%)
• Frequent urination (up to 12%)
• Weakness (up to 12%)
• Dizziness (up to 12%)

Treatment of dry mouth from Sjögren's syndrome:

• Sweating (40%)
• Frequent urination (10%)
• Flushing (9%)
• Chills (4%)

• Possible worsening of medical conditions
• Vision changes
• Dose too high