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Blujepa vs. Macrobid

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Blujepa

(gepotidacin)

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Nitrofurantoin

(Macrobid)

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Summary for Blujepa

Prescription only

Blujepa (gepotidacin) is an antibiotic pill used to treat certain common infections, including uncomplicated urinary tract infections (UTIs) and gonorrhea in some people 12 years and older. It's the first antibiotic in a new class that works differently from others. The dose is taken twice a day for 5 days for a UTI, or as two high doses 12 hours apart for gonorrhea. Common side effects include diarrhea, nausea, and stomach pain.

Indications for Blujepa

  • Uncomplicated urinary tract infections (UTIs) in women and girls 12 years and older who weigh at least 40 kg (88 lbs)
  • Uncomplicated urinary and genital gonorrhea in people 12 years and older who weigh at least 45 kg (99 lbs) when other treatment options aren't available

Pros and Cons for Blujepa

Pros

  • Only need to take it for a short amount of time
  • Might work better for some people when other treatments haven’t helped
  • Approved for adults and children as young as 12 years old

Cons

  • Commonly causes diarrhea, nausea, and stomach pain
  • Interacts with many medications
  • Not recommended for people with serious kidney or liver problems

Common Side Effects for Blujepa

UTI:

  • Diarrhea (16%)
  • Nausea (9%)
  • Stomach pain (4%)
  • Passing gas (3%)
  • Headache (2%)
  • Soft stool (2%)
  • Dizziness (2%)
  • Vomiting (2%)
  • Vaginal yeast infection (1%)

Gonorrhea:

  • Diarrhea (49%)
  • Nausea (24%)
  • Stomach pain (8%)
  • Vomiting (6%)
  • Passing gas (6%)
  • Dizziness (5%)
  • Soft stool (5%)
  • Headache (3%)
  • Tiredness (3%)
  • Sweating (2%)

Warnings for Blujepa

  • Heart rhythm problems (QT prolongation)
  • Build-up of acetylcholine
  • Severe allergic reactions
  • Diarrhea from Clostridioides difficile infection

Summary for Macrobid

Prescription only

Nitrofurantoin (Macrobid) is an antibiotic used to treat or prevent a urinary tract infection (UTI). Some side effects include nausea, headache, and gas. It can also make your urine turn dark yellow or brown. Nitrofurantoin (Macrobid) doesn't have many interactions with other medications. There's a lower-cost generic version of nitrofurantoin (Macrobid) available.

Indications for Macrobid

  • Treatment or prevention of urinary tract infections

Pros and Cons for Macrobid

Pros

Cons

  • Might need to take up to four times a day (depending on the formulation)
  • Can interact with certain types of antacids, travel vaccines, and lab tests
  • Can harm your lungs, liver, and nerves if taken for a long period of time

Common Side Effects for Macrobid

  • Nausea (8%)
  • Headache (6%)
  • Gas (2%)

Warnings for Macrobid

  • Lung damage
  • Liver damage
  • Nerve damage (neuropathy)
  • Breakdown of red blood cells (hemolytic anemia)
  • Severe diarrhea

Prices with our coupons for Blujepa vs. Macrobid

Price Card Drug Icon
Blujepa20 tablets / 750mg
$1,830.25$2,273.02
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Price Card Drug Icon
Nitrofurantoin14 capsules / 100mg
$15.73$46.33
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