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Compare Amvuttra vs. Vyndaqel

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Amvuttra (vutrisiran)
    Vyndaqel (tafamidis)
  • Amvuttra (vutrisiran)
    Vyndaqel (tafamidis)

  • Summary of Amvuttra vs. Vyndaqel

    Summary for Small interfering ribonucleic acid (siRNA)
    Prescription only

    Amvuttra (vutrisiran) is a prescription injection used to treat nerve damage (polyneuropathy) in adults with a rare condition called hereditary transthyretin-mediated amyloidosis (hATTR). It's also FDA approved to treat heart muscle problems (cardiomyopathy) in adults with either wild-type transthyretin-mediated amyloidosis (ATTRwt) or hATTR. This medication belongs to a drug class called small interfering ribonucleic acids (siRNAs) and is injected under the skin once every 3 months by a healthcare professional. Some common side effects include joint pain and shortness of breath.

    Summary for TTR stabilizer
    Prescription only

    Vyndaqel (tafamidis) is a medication taken by mouth used for a rare type of heart disease called transthyretin-mediated amyloidosis cardiomyopathy (ATTR-CM). It's available as two different brand names and is taken once per day.

  • Indications of Amvuttra vs. Vyndaqel

    Indications for
    •Polyneuropathy (nerve damage) from hereditary ATTR amyloidosis (hATTR)
    •Cardiomyopathy (heart muscle problems) from wild-type transthyretin-mediated amyloidosis (ATTRwt) or hATTR
    Indications for
    •Transthyretin-mediated amyloidosis cardiomyopathy (ATTR-CM, a rare heart muscle disease)

  • Pros and Cons of Amvuttra vs. Vyndaqel

    Pros and Const for Small interfering ribonucleic acid (siRNA)
    Pros
    •Injected once every 3 months
    •Given under the skin, instead of through the veins
    •Doesn't require pretreatment medications
    •Treats both nerve and heart problems from ATTR
    Cons
    •Likely to cause low vitamin A levels
    •Needs to be given by a healthcare professional
    •Unknown if safe or works well in children
    •Maybe not safe during pregnancy
    Pros and Const for TTR stabilizer
    Pros
    •The first once-daily, oral treatment for ATTR-CM
    •Can help lower chance of hospitalizations and death in people with ATTR-CM
    •Can be taken with or without food
    •Manufacturer financial assistance available
    Cons
    •Need to take four capsules for one dose of Vyndaqel (tafamidis)
    •Available as brand names only, which can be very expensive
    •Not recommended for use during pregnancy

  • Common Side Effects of Amvuttra vs. Vyndaqel

    Common Side Effects for
    •Pain in arms and legs (15%)
    •Joint pain (11%)
    •Shortness of breath (7%)
    •Lower vitamin A levels (7%)
    Common Side Effects for

    The following side effects listed in the supplemental appendix of a major clinical study were similar in people taking Vyndaqel (tafamidis) and people taking placebo. Side effects were generally mild to moderate in severity.

    •Bone, muscle, or joint problems (49%)
    •Injury (41%)
    •Skin problems (29%)
    •Heart failure (15-29%)
    •Falls (27%)
    •Mental health problems (24%)
    •Atrial fibrillation (heart rhythm problem, 19%)
    •Shortness of breath (19%)
    •Swelling of the hands, feet, or ankles (18%)
    •Tiredness (17%)
    •Dizziness (16%)
    •Eye problems (16%)
    •Constipation (15%)
    •Reproductive or breast problems (15%)

  • Warnings of Amvuttra vs. Vyndaqel

    Common Side Effects for
    •Low vitamin A levels
    Common Side Effects for

  • Prices with our coupons for Amvuttra vs. Vyndaqel

    Learn more about Amvuttra
    Learn more about Vyndaqel

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