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Amiloride vs. Spironolactone

Amiloride is a potassium-sparing diuretics used to prevent low potassium levels in the blood when taken with certain medications that treat high blood pressure or heart failure. It comes in tablet form, taken by mouth once per day with food. Side effects include headache, nausea, and loss of appetite. While it's available as a generic, the brand name Midamor is no longer on the market.

• To prevent low potassium levels in the blood when used with certain diuretic medications that treat high blood pressure and heart failure

• Headache (up to 8%)
• Nausea (up to 8%)
• Loss of appetite (up to 8%)
• Vomiting (up to 8%)
• Diarrhea (up to 8%)

• High potassium levels

Spironolactone (Aldactone) is a type of potassium-sparing diuretic (water pill). It's used to treat heart failure, high blood pressure, and swelling from kidney or liver problems in adults. Because it blocks aldosterone (a hormone that affects sodium and potassium levels), spironolactone (Aldactone) can also treat conditions where there's too much aldosterone. Spironolactone (Aldactone) is taken by mouth, generally once or a few times a day, depending on your condition. Some common side effects of this medication include breast tenderness (males and females) and loss of libido (in males).

• Heart failure
• High blood pressure
• Swelling due to liver damage (cirrhosis)
• Swelling due to nephrotic syndrome (a rare kidney condition) - tablets only
• Primary aldosteronism (a hormone imbalance) - tablets only

• Dizziness
• Headache
• Sleepiness
• Nausea
• Vomiting
• Diarrhea
• Stomach cramps
• Enlargement of male breasts
• Breast pain
• Lower sex drive
• Sexual dysfunction
• Irregular or lack of menstrual periods
• Leg cramps
• Higher potassium levels
• Lower sodium levels

• High blood potassium levels
• Low blood pressure and kidney problems
• Abnormal electrolyte levels
• Breast pain or swelling