Pleuromutilin antibiotics are used to treat skin infections and community-acquired bacterial pneumonia (CABP). These antibiotics work by blocking bacterial proteins from being made, which stops the bacteria from growing and spreading. Pleuromutilin antibiotics come in different forms, including topical ointments and oral tablets. Examples include retapamulin (Altabax) for topical use and lefamulin (Xenleta) for intravenous use. You can choose the form that best fits your needs.