Angptl3-inhibitors are used to lower bad cholesterol levels in people with homozygous familial hypercholesterolemia (HoFH). Angptl3-inhibitors work by blocking a protein called angiopoietin-like 3 (ANGPTL3) that stops the body from clearing out bad cholesterol. In doing so, angptl3-inhibitors allow the body to remove bad cholesterol. These medications are typically available as infusions. An example of an angptl3-inhibitor is evinacumab (Evkeeza).