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Cevimeline Coupon - Cevimeline 30mg capsule

cevimeline

Generic Evoxac
Used for Dry Mouth
Used for Dry Mouth

Cevimeline, also known by its brand name, Evoxac, is a prescription cholinergic agonist used to treat dry mouth (xerostomia) in adults with Sjögren's syndrome. It's available as both brand-name and generic capsules, with a typical dose of 30 mg taken by mouth three times per day. The most common side effects are excessive sweating, nausea, and headache.

Last reviewed on September 24, 2024
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What is Cevimeline (Evoxac)?

What is Cevimeline (Evoxac) used for?

How Cevimeline (Evoxac) works

Cevimeline (Evoxac) is a cholinergic agonist. It works by attaching to and activating certain proteins in your salivary glands called acetylcholine receptors. This helps your glands make more saliva, so your mouth feels less dry.

Drug Facts

Common BrandsEvoxac
Drug ClassCholinergic agonist
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
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What are the side effects of Cevimeline (Evoxac)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Sweating (19%)
  • Headache (14%)
  • Nausea (14%)
  • Sinus inflammation (12%)
  • Runny nose (11%)
  • Diarrhea (10%)
  • Stomach discomfort and pain (8%)
  • Urinary tract infection (6%)
  • Coughing (6%)
  • Vomiting (5%)

Other Side Effects

  • Back pain
  • Joint pain
  • Rash
  • Dizziness
  • Changes in vision
  • Fatigue
  • Anxiety
  • Flushing
  • Trouble sleeping
  • Frequent urination

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Too much medication: excessive sweating, breathing problems, headache, visual changes, producing more tears, nausea, vomiting, diarrhea, heart rate changes, confusion, tremor

Source: DailyMed

The following side effects have also been reported

Check with your doctor or nurse immediately if any of the following side effects occur:

Check with your doctor immediately if any of the following side effects occur:

More common

Bladder pain

bloody or cloudy urine

body aches or pain

chills

cough

difficult, burning, or painful urination

difficulty in breathing

dryness or soreness of the throat

ear congestion

frequent urge to urinate

headache

hoarseness

loss of voice

lower back or side pain

runny or stuffy nose

sneezing

tender, swollen glands in the neck

trouble in swallowing

unusual tiredness or weakness

voice changes

Less common

Accumulation of pus

bloating or swelling of the face, arms, hands, lower legs, or feet

blurred vision or other change in vision

burning, dry, or itching eyes

chest pain

cough producing mucus

diarrhea

discharge, excessive tearing

dizziness

earache

excessive muscle tone

eye pain

fast, irregular, pounding, or racing heartbeat or pulse

feeling unusually cold

fever

general feeling of discomfort or illness

headache, severe and throbbing

heartburn

hives, skin rash

joint pain

loss of appetite

muscle pain, stiffness, tension, or tightness

nausea

nosebleed

pale skin

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

rapid weight gain

redness or swelling in the ear

redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid

sensitivity of the eye to light

shivering

sore throat

swollen, red, tender area of the infection site

tightness in the chest

tingling of the hands or feet

tremor

trouble sleeping

unusual bleeding or bruising

unusual weight gain or loss

vomiting

weight loss

Rare

Anxiety

black, tarry stools

bleeding after defecation

bleeding gums

blisters

bloating

blood in the urine or stools

blood in vomit

bloody nose

blue or pale skin

burning feeling in the chest or stomach

burning feeling while urinating

burning, numbness, pain, or tingling in all fingers, except the smallest finger

burning, tingling, numbness or pain in the hands, arms, feet, or legs

changes in skin color

chest discomfort

chest pain, possibly moving to the left arm, neck, or shoulder

choking

clumsiness or unsteadiness

cold sweats

collection of blood under the skin

confusion

constipation

cool, pale skin

coughing or spitting up blood

cracked lips

decreased urination

deep, dark purple bruise

depressed mood

difficulty controlling your bladder or bowels

difficulty walking

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

dry mouth

dry skin and hair

dry, puffy skin

extra heartbeat

fainting

feeling cold

forgetfulness

frequent urge to defecate

fruit-like breath odor

gaseous abdominal pain

heart murmur

heavier menstrual periods

husky voice

incoherent speech

increase in heart rate

increased hunger

increased thirst

increased volume of pale, dilute urine

indigestion

involuntary muscle contractions

irregular heartbeat

irritation or soreness of the mouth

itching, pain, redness, swelling, tenderness, or warmth on the skin

joint stiffness or swelling

lightheadedness

loss of bladder control

loss of consciousness

lower back, side, or stomach pain

metallic taste

mood changes

muscle cramps or weakness

nerve pain

nervousness

nightmares

noisy breathing

numbness or tingling in the face, hands, feet, or lips

pain in the arms, legs, or lower back, especially pain in the calves or heels upon exertion

pain or burning in the throat

pain or discomfort in the arms, jaw, back, or neck pain, warmth, or burning in the fingers, toes, and legs

painful blisters on the trunk of the body

painful cold sores or blisters on the lips, nose, eyes, or genitals

pale, bluish-colored, or cold hands or feet

pinpoint red spots on the skin

pounding in the ears

rapid, shallow breathing

rectal bleeding

recurrent fever

redness and swelling of the gums

redness, soreness, or itching skin

redness, swelling, or soreness of the tongue

seizures

sensation of pins and needles

severe constipation

severe cramping

severe or continuing stomach pain

severe stomach pain

severe vomiting

shakiness

slow heartbeat

slurred speech

sores, ulcers, or white spots on the lips or tongue or inside the mouth

stabbing pain

stomach bloating, burning, cramping, or pain

stomach tenderness or discomfort

stomach upset or fullness

straining while passing stool

sudden decrease in the amount of urine

sunken eyes

sweating

swelling around the eyes

swelling of the front part of the neck

swelling or inflammation of the mouth

swollen, painful, or tender lymph glands in the neck, armpit, or groin

trouble in holding urine

uncomfortable swelling around the anus

unexplained weight loss

voice changes

vomiting of blood or material that looks like coffee grounds

weak or absent pulses in the legs

weight gain

wrinkled skin

yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of Overdose

Blurred or loss of vision

chest pain or discomfort

cold, clammy skin

confusion

disturbed color perception

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

double vision

fainting fast, pounding, or irregular heartbeat or pulse

fast, weak pulse

halos around lights

nervousness

night blindness

overbright appearance of lights

pounding in the ears

pounding, slow heartbeat

stomach cramps or pain

tearing of the eyes

tightness in the chest

tremor

troubled breathing

tunnel vision

unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Back pain

belching

bloated, full feeling

bone pain

change in the color, amount, or odor of vaginal discharge

difficulty in moving

discouragement

excess air or gas in stomach or bowels

feeling of constant movement of self or surroundings

feeling of warmth feeling sad or empty

hiccup

increased watering of the mouth

irritability

itching of the vagina or genital area

leg cramps

loss of interest or pleasure

overactive reflexes, followed by underactive reflexes

pain during sexual intercourse

passing gas

redness of the face, neck, arms, and occasionally, upper chest

salivary gland enlargement or pain

sensation of spinning

thick, white vaginal discharge with no odor or with a mild odor

tooth disorder

toothache

trouble concentrating

Rare

Abnormal crying

abnormal dreaming

absence of menstruation

acne

agitation

change in tongue color

changes in menstrual periods

decreased sexual ability in males

difficulty in speaking

discoloration of the fingernails or toenails

false beliefs that cannot be changed by facts

feeling of unreality

hair loss or thinning of hair

increase in body movements

increased appetite

increased sensitivity of skin to sunlight

lack or loss of strength

painful menstruation

poor insight and judgment

problems with memory or speech

seeing, hearing, or feeling things that are not there

sense of detachment from self or body

severe sunburn

sleepiness or unusual drowsiness

trouble recognizing objects

trouble thinking and planning

trouble walking

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Cevimeline (Evoxac)

thumbs-up

Pros

FDA approved to treat dry mouth from Sjögren's syndrome

Available as a lower-cost generic

Might have less side effects than alternative pilocarpine (Salagen)

thumbs-down

Cons

Can affect your vision and make it harder to see, especially at night

Need to take a dose three times per day

Interacts with a lot of medications

pharmacist-tips

Pharmacist tips for Cevimeline (Evoxac)

pharmacist
  • You can take cevimeline (Evoxac) with or without food. If the medication upsets your stomach, try taking it with food to help. Keep in mind that taking it with food can slow down how quickly cevimeline (Evoxac) is absorbed in your body, which might affect when it starts to work.

    • If needed, ask your prescriber about taking saliva substitutes with cevimeline (Evoxac) for extra help with dry mouth.

      • Cevimeline (Evoxac) can make you dizzy. It can also cause vision changes, such as blurry vision or trouble judging distance and depth, especially when it's dark. Don't drive, operate machinery, or do anything that requires concentration until you know how this medication affects you.

        • Cevimeline (Evoxac) can make you sweat and urinate more. It's important to stay well-hydrated to help prevent dehydration from these side effects.

          • Cevimeline (Evoxac) interacts with a lot of medications. Be sure to tell your care team about everything you're taking before and during treatment. It's a good idea to share a medication list with them so they can make sure all your medications are safe to take together.

            • The safety of cevimeline (Evoxac) during pregnancy or breastfeeding hasn’t been well studied, so it should only be used if absolutely necessary. Talk to your prescriber about the risks and benefits of using cevimeline (Evoxac) if you’re pregnant, planning to become pregnant, or breastfeeding.

              faqs

              Frequently asked questions about Cevimeline (Evoxac)

              How well does cevimeline (Evoxac) work?
              A study showed people taking cevimeline (Evoxac) for 6 weeks had significant improvements in dry mouth because it helped them produce more saliva, reducing the need for saliva substitutes. Though treatment guidelines recommend it lightly, cevimeline (Evoxac) is still listed as an option to boost saliva production to help prevent tooth decay.
              What's the difference between cevimeline (Evoxac) and pilocarpine?
              Both cevimeline (Evoxac) and pilocarpine (Salagen) are cholinergic agonists that help to produce more saliva. While both are approved for treating dry mouth caused by Sjögren's syndrome, pilocarpine (Salagen) is also approved for dry mouth due to radiation therapy for cancer. A study comparing both medications found that they work equally well, but pilocarpine (Salagen) might have more side effects. Treatment guidelines list both medications as options to raise saliva production. Talk to your prescriber if you have more questions about the differences between these medications.
              What alternatives are there for cevimeline (Evoxac)?
              The only FDA approved alternative medication to cevimeline (Evoxac) is pilocarpine (Salagen). Additionally, there are a few other home remedies that you can try, such as chewing gum, using saliva substitutes, or sipping liquid. Discuss with your prescriber about which remedies might be right for you.
              What medications interact with cevimeline (Evoxac)?
              Cevimeline (Evoxac) generally shouldn't be taken with anticholinergic medications because they work in opposite ways. Cevimeline (Evoxac) raises acetylcholine levels, whereas anticholinergics reduce it. Also, taking cevimeline (Evoxac) with beta blockers can raise the risk of heart problems. Many other medications can interact with cevimeline (Evoxac), so it's important to let your care team know about all of the medications you're taking so they check to make sure they're safe to take together.
              Does cevimeline (Evoxac) cause weight gain?
              Cevimeline (Evoxac) can affect your weight, but it's not common. In studies, there have been reports of both weight gain and weight loss in less than 1% of people taking this medication. Contact your prescriber if you notice unexpected changes in your weight. They can help identify what might be causing it
              Can you use cevimeline (Evoxac) for dry eyes?
              Cevimeline (Evoxac) isn't FDA approved to treat dry eyes. But a study found cevimeline (Evoxac) worked well to treat dry eyes in people with Sjögren's syndrome. Speak with your prescriber if you have questions about taking this medication for dry eyes.
              Can you drink alcohol while you're taking cevimeline (Evoxac)?
              It's generally recommended to avoid alcohol while taking cevimeline (Evoxac). Doing so can worsen side effects like nausea, diarrhea, and frequent urination. It can also lower your blood pressure, affect your vision, or make you dehydrated. Talk to your care team if you have more questions about drinking alcohol with this medication.
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              What are the risks and warnings for Cevimeline (Evoxac)?

              Cevimeline (Evoxac) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

              risk-warning

              Worsening heart problems

              • Risk factors: History of chest pain or heart attack

                Cevimeline (Evoxac) can affect your heart's electrical activity, potentially changing the heart rate and heart rhythm. If you have a history of chest pain or heart attack, your heart might not handle these changes well. Be sure to let your prescriber know if you have a history of heart problems.

                risk-warning

                Worsening lung problems

                • Risk factors: Asthma | Bronchitis | COPD

                  Cevimeline (Evoxac) can make it harder for air to flow through your lungs, harder for your lung muscles to relax, and might increase mucus production in your lungs. Overall, this will make it harder for you to breathe. Talk to your prescriber about any lung problems that you have, such as asthma or chronic obstructive pulmonary disease (COPD), before starting this medication.

                  risk-warning

                  Vision changes

                  Cevimeline (Evoxac) can affect the muscles in your eyes, causing blurry vision. It might be harder for you to see at night or do any activities with low lighting. Don't drive until you know how this medication affects you.

                  risk-warning

                  Gallstones or kidney stones

                  • Risk factors: History of gallstones or kidney stones

                    If you have a history of gallstones or kidney stones, let your prescriber know before taking cevimeline (Evoxac). This medication can affect the way your muscles contract, leading to swelling or blockage in your gallbladder duct. It can also affect the flow of urine and cause kidney stones to form in your urinary tract.

                    dosage

                    Cevimeline (Evoxac) dosage forms

                    The average cost for 90 capsules of 30mg of Cevimeline (Evoxac) is $71.24 with a free GoodRx coupon. This is 64.93% off the average retail price of $203.14.
                    capsule
                    Capsule
                    DosageQuantityPrice as low asPrice per unit
                    30mg90 capsules$71.24$0.79

                    Typical dosing for Cevimeline (Evoxac)

                    The typical dose is 30 mg by mouth three times a day.

                    interactions

                    Interactions between Cevimeline (Evoxac) and other drugs

                    Cevimeline (Evoxac) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Cevimeline (Evoxac). Please note that only the generic name of each medication is listed below.

                    Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

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                    How much does Cevimeline (Evoxac) cost?

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                    Cevimeline (Evoxac) contraindications

                    Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Cevimeline (Evoxac) will not be safe for you to take.
                    alternatives

                    What are alternatives to Cevimeline (Evoxac)?

                    There are a number of medications that your doctor can prescribe in place of Cevimeline (Evoxac). Compare a few possible alternatives below.
                    Cevimeline (Evoxac)
                    $71.24 Lowest GoodRx priceView Prices
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                    $32.81 Lowest GoodRx priceView Prices
                    images

                    Cevimeline (Evoxac) images

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                    White Logo A20 - Cevimeline Hydrochloride 30mg Capsule
                    This medicine is White Capsule Imprinted With "Logo A20".White Logo A20 - Cevimeline Hydrochloride 30mg Capsule

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                    References

                    Best studies we found
                    View All References (5)

                    Lott, E. L., et al. (2022). Cholinergic toxicity. StatPearls.

                    Ono, M., et al. (2004). Therapeutic effect of cevimeline on dry eye in patients with Sjögren's syndrome: A randomized, double-blind clinical study. American Journal of Ophthalmology.

                    Rising Pharma Holdings, Inc. (2024). Cevimeline hydrochloride capsule [package insert]. DailyMed.

                    Sam, C., et al. (2023). Physiology, acetylcholine. StatPearls.

                    Sjögren’s Foundation. (n.d.). Oral management: Caries prevention in Sjögren’s patients.

                    GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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