How Much Does Insulin Cost? – Here’s How 22 Brands Compare

Benita Lee
Benita Lee, MPH, is on the Research Team at GoodRx.
Posted on

Despite outrage over the high cost of insulin, prices for popular insulin treatments have continued to climb in 2018, according to a GoodRx analysis of drug prices.

Though prices are not climbing as quickly as they did between 2002 and 2013—when the average cost of insulin therapy tripled—the average price of insulin has increased by 64% since January 2014. The most recent price increases are on insulins made by Sanofi-Aventis and Novo Nordisk, which raised prices by as much as 3% in May and July of this year, respectively. Insulins by Sanofi-Aventis saw a price bump immediately after the manufacturer vowed to limit annual price increases to a rate below medical inflation (effectively 5.4%). Novo Nordisk promised just months before to cap annual price increases to single-digit percentages.

The analysis on 22 insulin brands across manufacturers and insulin types—short-, intermediate-, rapid- and long-acting—shows that manufacturers are still raising insulin prices, and costs now vary by as much as 10 times depending on which insulin you take. Here, we’ll walk you through how each brand stacks up and how you can get the best deal on these life-saving medications.

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This GoodRx analysis is based on a representative sample of US prescription fills (not GoodRx fills) and comes from several sources, including pharmacies and insurers. The reported prices per insulin unit are based on cash prices, the so-called “usual and customary” prices or retail prices at the pharmacy (not including insurance copays or co-insurance).

A note about insulin use:

One insulin unit can be defined as the amount of insulin it takes to lower blood glucose by 50 mg/dL, although each individual’s response is highly variable. Someone with type 2 diabetes may start with one unit of insulin per one to two kilograms of body weight per day, which equates to about 40 units of insulin per day for a 70-kg person.

People with type 2 diabetes are often treated without insulin—or perhaps one type of intermediate- or long-acting insulin—as type 2 diabetes is a disease where the body is resistant to insulin’s effects. For those with type 1 diabetes, an autoimmune disorder that kills pancreatic cells that make insulin, more insulin of different types is needed. It’s common, for example, for a person with type 1 diabetes to use both a mealtime (rapid- or short-acting) insulin along with a basal (intermediate- or long-acting) insulin.

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How do insulin prices compare today?

1) Traditional insulins are cheaper than modern insulins

Prices of Novolin and Humulin (traditional short- and intermediate-acting insulins) have turned south, while prices of modern rapid- and long-acting insulins continue to go up. On average, traditional insulins now cost less than half of what modern insulins cost.

Why? Understandably, traditional insulins have always been cheaper than their newer competitors. Modern insulins offer better blood sugar control but are synthetic analogs of traditional insulins, which makes them more difficult to produce. 

Additionally, when patents on Humulin and Novolin expired around 2000—after protecting these brands from competition for nearly 40 yearsmanufacturers Eli Lilly and Novo Nordisk have had to test new pricing strategies to remain competitive.

Last March, for example, Novo Nordisk partnered with CVS to offer Novolin at roughly 80% less than its normal list price. Both Novo Nordisk and Eli Lilly have also worked with Walmart to heavily discount Novolin and Humulin under Walmart’s ReliOn line of insulin products.

Retail partnerships haven’t been their only strategy. Last May, Eli Lilly broke from their routine of increasing Humulin prices every six months and has since left prices alone. In fact, prices of traditional Humulin and Novolin insulins, their rapid-acting analogs (Humalog and Novolog) and their mixed products (e.g. Humulin 70/30, Novolog 70/30) have not gone up since then.

Novolin R and Novolin N are currently the cheapest traditional insulins, by as much as 75% compared to other options.

Cash Prices of Traditional Insulins (July 2018)

Price per dispenser Price per insulin unit
Regular insulin
Novolin R vial (10 ml) $116 per vial $0.12 per unit
Humulin R vial (10 ml) $191 per vial $0.19 per unit
Humulin R vial (20 ml, 500 units/ml) $1862 per vial $0.19 per unit
Humulin R Kwikpen (3 ml, 500 units/ml) $358 per pen $0.24 per unit
NPH insulin
Novolin N vial (10 ml) $102 per vial $0.10 per unit
Humulin N vial (10 ml) $186 per vial $0.19 per unit
Humulin N Kwikpen (3 ml) $119 per pen $0.40 per unit
*Insulin concentrations are 100 units/ml unless otherwise stated.

 

2) Vials are cheaper than newer dispensers

In 1985, Novo Nordisk introduced the first insulin pen, making it more convenient for patients to store and self-inject insulin—but it came at a price. Today, rapid-acting insulins are 30% more expensive if you buy them as pens versus vials. It’s not just rapid-acting insulins either; the price of Humulin N, for example, more than doubles if you choose to use a Kwikpen instead of a vial.

New dispensers make insulin more expensive. We’re seeing that again with Afrezza, a relatively new rapid-acting insulin, and the first and only insulin to be delivered as an inhalable powder. One unit of Afrezza’s insulin can cost as much as three times other rapid-acting insulins.

Cash Prices of Rapid-Acting Insulins (July 2018)

Price per dispenser Price per insulin unit
Insulin lispro
Admelog vial (10 ml) $303 per vial $0.30 per unit
Humalog vial (10 ml) $340 per vial $0.34 per unit
Admelog Solostar pen (3 ml) $117 per pen $0.39 per unit
Humalog Kwikpen (3 ml) $135 per pen $0.45 per unit
Insulin aspart
Novolog vial (10 ml) $341 per vial $0.34 per unit
Novolog Flexpen (3 ml) $130 per pen $0.44 per unit
Insulin glulisine
Apidra vial (10 ml) $349 per vial $0.35 per unit
Apidra Solostar pen (3 ml) $136 per pen $0.45 per unit
Inhaled insulin
Afrezza cartridge (4 units) $3.60 per cartridge $0.90 per unit
*Insulins concentrations are 100 units/ml unless otherwise stated.

 

3) Follow-ons (“generic insulins”) cost a little less than brands

You’d think follow-ons, what we call the generic versions of insulin, would be much cheaper than brand-name insulins. However, our current follow-ons, Basaglar and Admelog, only offer minimal savings.

Basaglar, a long-acting insulin approved in 2016, is the follow-on to Lantus, andAdmelog, a rapid-acting insulin approved in 2017, is the follow-on to Humalog. Today, Basaglar costs about 15% less than Lantus on a per insulin unit basis. Admelog, similarly, costs 12% to 15% less than Humalog, depending on the dispenser. By cash price alone, both Basaglar and Admelog are still the cheapest options of their insulin groups.

4) New product features can come with a high price tag

Novelty can translate to higher prices, but not always. In the last couple years, we gained four new long-acting insulin brands: Tresiba, Xultophy, Soliqua 100/33, and Toujeo.

Tresiba is an ultralong-acting insulin that stays active for up to 42 hours. For this unique property, it costs about $115 per 3-ml pen, or 39% more than fellow long-acting insulin, Basaglar. 

Then, there’s Xultophy and Soliqua 100/33. Both contain a long-acting insulin and another non-insulin diabetes medication. Xultophy is a mix of insulin degludec plus liraglutide (the same active ingredient in Victoza), and Soliqua is a mix of insulin glargine plus lixisenatide (the same active ingredient in Adlyxin). Soliqua and Xultophy are more than the double the price of cheaper alternatives like Basaglar and Tresiba, which have the same exact kind of insulins.

Lastly, there’s Toujeo, a good example of when a special feature doesn’t make the drug cost more. It has the same insulin as Lantus, but is three times more concentrated. For people who need more insulin than average, that’s a convenient feature. At first glance, Toujeo’s price seems expensive at about $150 per 1.5-ml pen, but one insulin unit actually costs about the same as one unit of Lantus—it’s just that you get more insulin with each injection. 

What’s next for insulin prices? At the end of 2017, long-acting insulins started to get more expensive overall, after having enjoyed stable prices since 2015. As we mentioned, Novo Nordisk and Sanofi-Aventis raised their insulin prices again, despite promising to help reign in drug prices.

Specifically, Novo Nordisk bumped up prices of Tresiba and Levemir in January of this year, and then again in July. Sanofi-Aventis raised prices for Toujeo and Lantus in October 2017, and then again in May. Xultophy and Soliqua both saw price bumps back in January of this year.

As might be expected, these manufacturers did not limit their recent price increases to long-acting insulins. Their rapid-acting insulins, Apidra and Novolog, saw new price increases last month as well.

All together, prices of long-acting insulins increased by about 7% since September of last year.

Cash Prices of Long-Acting Insulins (July 2018)

Price per dispenser Price per insulin unit
Insulin detemir
Levemir Flextouch pen (3 ml) $105 per pen $0.35 per unit
Levemir vial (10 ml) $368 per vial $0.37 per unit
Insulin glargine
Basaglar Kwikpen (3 ml) $83 per pen $0.28 per unit
Lantus vial (10 ml) $332 per vial $0.33 per unit
Lantus Solostar pen (3 ml) $98 per pen $0.33 per unit
Toujeo pen (1.5 ml, 300 units/ml) $154 per pen $0.34 per unit
Toujeo Max pen (3 ml, 300 units/ml) $300 per pen $0.33 per unit
Soliqua 100/33 Solostar pen (3 ml) $165 per pen $0.55 per unit
Insulin degludec
Tresiba Flextouch pen (3 ml) $115 per pen $0.38 per unit
Xultophy pen (3 ml) $249 per pen $0.83 per unit
*Insulins concentrations are 100 units/ml unless otherwise stated.

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Ways to save on insulin

It’s difficult to predict where drug prices will be in the future, but if you take insulin, we hope our analysis gives you some ideas for how to talk to your doctor about affordable options. Here are more ways you can save:

  1. Use a manufacturer savings card or patient assistance program. Major insulin manufacturers Eli Lilly, Novo Nordisk, Sanofi-Aventis, and MannKind offer copay cards and patient assistance programs for patients with and without insurance coverage. In many cases, these programs can reduce out-of-pocket costs to as little as $0 per month. For more information, just search for your drug on GoodRx.com, and click on “Savings Tips” for details.
  2. Shop around. GoodRx offers coupons on insulin drugs, which can save you as much as 50% off the full retail price. At GoodRx.com, you can also compare insulin prices at different pharmacies in your area and find information about discount programs at specific pharmacies.
  3. Appeal your coverage. If you have insurance and your plan doesn’t cover the insulin you need, ask your doctor about submitting an appeal. This may require a prior authorization or step therapy before you can fill your prescription, but it’s worth trying if you want to get your insulin covered.

Co-contributors: Clement B. Feyt, MPH & Jeroen van Meijgaard, PhD
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