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Bexarotene

Bexarotene Side Effects

Julia Lee, PharmD, BCOPDaisy Chau, PharmD
Reviewed by Julia Lee, PharmD, BCOP, Daisy Chau, PharmD
Last reviewed on May 16, 2025

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Higher levels of fat or cholesterol in the blood (up to 79%)
  • Headache (37%)
  • Lower thyroid hormone level (29%)
  • Feeling weak or tired (up to 20%)

Less Common Side Effects

  • Rash or dry skin
  • Nausea or vomiting
  • Stomach pain
  • Infection
  • Swelling in the arms, feet, or ankles
  • Lower neutrophil counts in the blood

Bexarotene serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Inflammation of the pancreas (pancreatitis): nausea, vomiting, stomach pain, back pain
  • Liver problems: yellowing the eyes, yellowing of the skin, reduced appetite, unusual bleeding, bruising
When do Bexarotene possible side effects begin and end?
Time passed since treatment started:
H
D
W
M
Higher levels of fat or cholesterol

Source: DailyMed

The following Bexarotene side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Since this medication is given in varying doses, the actual frequency of side effects may vary. In general, side effects are less common with lower doses than with higher doses.

Check with your doctor as soon as possible if any of the following side effects occur:

More common

Unusual tiredness or weakness

skin rash or other skin and mucous membrane lesions

fever

increase in lipid or cholesterol levels

coldness, dry, puffy skin or weight gain

chills, cough, hoarseness, lower back or side pain or painful or difficult urination

swelling of the arms, feet, hands, or legs

Less Common

Severe stomach pain with nausea or vomiting

shortness of breath

yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Abdominal pain

hair loss

loss of appetite

loss of strength or energy, tiredness or weakness

back pain

diarrhea

dry skin

general feeling of discomfort or illness

trouble in sleeping

headache

nausea or vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Julia is a clinical hematology/oncology pharmacist working in the San Francisco Bay Area. She has 3 years of experience as a practicing pharmacist at academic medical centers, with 2 years at National Comprehensive Cancer Network member hospitals.
Daisy Chau, PharmD
Reviewed by:
Daisy Chau, PharmD
Daisy Chau, PharmD, is the drug information pharmacist manager at GoodRx. She is licensed in California and has more than 6 years of experience working as a pharmacist in drug information.

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