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The controversy surrounding hydroquinone stems from its safety concerns and regulatory status. While it's an effective skin-lightening agent, its long-term use has been linked to potential risks, including bluish-gray skin discoloration and skin irritation. Due to these risks and regulatory changes associated with the CARES Act, the FDA banned over-the-counter hydroquinone products in 2020. While Tri-Luma (fluocinolone / hydroquinone / tretinoin) is the only FDA-approved product containing hydroquinone, compounded formulations or prescription-only hydroquinone creams may still be available under medical supervision.
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