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Amitiza

Amitiza Side Effects

Robert Chad Hakim, PharmD, BCCCPCydnee Ng, PharmD
Reviewed by Robert Chad Hakim, PharmD, BCCCP, Cydnee Ng, PharmD
Last reviewed on March 11, 2026

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Nausea (29%)
  • Diarrhea (12%)
  • Headache (11%)
  • Stomach pain (8%)
  • Stomach bloating (6%)
  • Feeling gassy (6%)

Less Common Side Effects

  • Vomiting
  • Indigestion
  • Loose stools
  • Swelling from fluid buildup
  • Dizziness
  • Chest discomfort or pain
  • Trouble breathing
  • Tiredness
  • Dry mouth

Note: Side effects were from adults with chronic constipation. Side effects might be different for other types of constipation.

Amitiza serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Severe diarrhea
  • Low blood pressure or fainting: dizziness, lightheadedness
  • Trouble breathing: chest tightness, trouble taking in a breath
When do Amitiza possible side effects begin and end?
Time passed since treatment started:
M
H
D
W
M
Nausea
Diarrhea
Trouble breathing
Low blood pressure or fainting
Seek immediate medical care if you experience this side effect.

Source: DailyMed

The following Amitiza side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Diarrhea

full or bloated feeling or pressure in the stomach

nausea

stomach pain

swelling of the abdominal or stomach area

Less common

Black, tarry stools

blood in the stools

chest discomfort or pain

chills

colds

cough

difficult or labored breathing

fever

general feeling of discomfort or illness

headache

increased sweating

joint pain

loss of appetite

loss of bowel control

muscle aches and pains

runny nose

shivering

sore throat

stomach discomfort

sweating

tightness in the chest

trouble sleeping

unusual tiredness or weakness

vomiting

Incidence not known

Blurred vision

confusion

difficulty with swallowing

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

fainting

fast, pounding, or irregular heartbeat or pulse

hives or skin rash

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

stomach tenderness

swelling

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Dry heaves

dry mouth

feeling of warmth

lack or loss of strength

paleness of the skin

redness of the face, neck, arms, and occasionally, upper chest

severe, unusual tiredness or weakness

weight loss

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Excess air or gas in the stomach or intestines

passing gas

Less common

Belching

bladder pain

bloody or cloudy urine

change in taste

cold sweats

difficult, burning, or painful urination

difficulty with moving

discouragement

dizziness

fear or nervousness

feeling sad or empty

frequent urge to urinate

heartburn

increased weight

indigestion

irritability

loss of interest or pleasure

loss of taste

lower back or side pain

muscle cramps

muscle stiffness

stomach upset

swollen joints

tingling of the hands or feet

unusual drowsiness, dullness, tiredness, or feeling of sluggishness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Robert Chad Hakim, PharmD, BCCCP, started his full-time career as a clinical pharmacist at UCLA Health in the general medicine, general cardiology, and ICU units after completing residency in 2016. He also was the preceptor for the general medicine rotation from 2017 to 2021, which was a required rotation for all pharmacy residents.
Cydnee Ng, PharmD
Reviewed by:
Cydnee Ng, PharmD
Cydnee Ng, PharmD, is a drug information pharmacist at GoodRx, where she lends her expertise to providing reader-friendly, accessible content about medications. She holds her pharmacist license in California.

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