Specialty Drug
INTERFERON Gamma-1b helps your immune system work better. In patients with chronic granulomatous disease, this medicine helps to fight infections. In children with osteoporosis, interferon gamma helps to slow the progression of the disease. Compare interferon gammas.

Actimmune Side Effects

What should I watch for?

Visit your doctor or health care professional for regular checks on your progress.

Reactions at the site of injection may occur. Ask your doctor or health care professional to suggest a series of injection sites, so that you do not have to use the same site repeatedly. You can use an injection site again after one week, providing the skin is not tender, red, or hard.

Flu-like symptoms are common with this medicine. Using this medicine at night can reduce the impact of these symptoms. Taking acetaminophen or ibuprofen before your injection may help lessen any fever or headache. Check with your doctor before using these medications.

Do not become pregnant while taking this medicine. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information.


Common and Rare Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common



Less common

Black, tarry stools

bleeding gums

blood in the urine or stools


cough or hoarseness

loss of balance control

lower back or side pain

mask-like face

painful or difficult urination

pinpoint red spots on the skin

shuffling walk

sore throat

stiffness of the arms or legs

trembling and shaking of the hands and fingers

trouble breathing

trouble speaking or swallowing

trouble thinking or concentrating

trouble walking

ulcers, sores, or white spots in the mouth

unusual bleeding or bruising

unusual tiredness or weakness

Incidence not known

Abdominal or stomach pain or tenderness

change in walking and balance

clay colored stools

clumsiness or unsteadiness

dark urine

decreased appetite

decreased frequency or amount of urine

general feeling of discomfort or illness


increased thirst

itching or skin rash

joint or muscle pain

loss of appetite

lower back or side pain

muscle aches and pains

nausea and vomiting

numbness or tingling of the face, hands, or feet

painful or difficult urination

pale skin

redness and soreness of the eyes

runny nose

shivering skin


swelling of the face, fingers, or lower legs

trouble sleeping

weight gain

yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common


redness or tenderness at the injection site

Less common

Back pain


weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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