Skip to main content
Sapropterin

Sapropterin Side Effects

Yen Nguyen, PharmDKristianne Hannemann, PharmD
Reviewed by Yen Nguyen, PharmD, Kristianne Hannemann, PharmD
Last reviewed on March 23, 2022

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Headache (15%)
  • Runny nose (11%)
  • Throat pain (10%)
  • Diarrhea (8%)
  • Vomiting (8%)
  • Cough (7%)
  • Stuffy nose (4%)

Less Common Side Effects

  • Low blood Phe levels
  • Rhinitis
  • Stomach pain

Sapropterin serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Severe allergic reaction: rash, trouble breathing, swelling of the lips, tongue, or throat
  • Severe stomach problems: stomach pain, nausea, vomiting, blood in vomit or stool, black tarry stools, trouble swallowing, loss of appetite, throat pain

Source: DailyMed

The following Sapropterin side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Fever

Incidence not known

Burning feeling in the chest or stomach

cough

difficulty with swallowing

dizziness

fast heartbeat

fidgeting or moving around too much

heartburn

indigestion

pain or burning in the throat

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

skin rash, hives, or itching

sores, ulcers, or white spots on lips or tongue or inside the mouth

stomach upset

talking too much

tenderness in the stomach area

tightness in the chest

trouble swallowing

unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Diarrhea

headache

runny nose

sore throat

vomiting

Less common

Stuffy nose

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Was this page helpful?