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Ranolazine

Ranolazine Side Effects

Sarah Lobello Pearson, PharmDKristianne Hannemann, PharmD
Reviewed by Sarah Lobello Pearson, PharmD, Kristianne Hannemann, PharmD
Last reviewed on January 26, 2026

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Dizziness (6%)
  • Headache (6%)
  • Constipation (5%)
  • Nausea (4%)

Less Common Side Effects

  • Palpitations (racing heart)
  • Stomach pain
  • Vomiting
  • Dry mouth
  • Blurry vision
  • Fluid buildup and swelling in the arms or legs

Ranolazine serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Abnormal heart rhythm: irregular heart beat, dizziness, chest pain, trouble breathing, fainting
  • Serious kidney problems: urinating more often, blood or foam in your urine, tiredness, dry or itchy skin, muscle cramps, swollen feet or ankles, poor appetite
When do Ranolazine possible side effects begin and end?
Time passed since treatment started:
H
D
W
M
Dizziness
Headache
Nausea
Constipation

Source: DailyMed

The following Ranolazine side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Dizziness

Less common

Bloating or swelling of the face, arms, hands, lower legs, or feet

continuous ringing or buzzing or other unexplained noise in the ears

difficult or labored breathing

fast, irregular, pounding, or racing heartbeat or pulse

feeling of constant movement of self or surroundings

hearing loss

lightheadedness

rapid weight gain

sensation of spinning

tightness in the chest

tingling of the hands or feet

unusual weight gain or loss

Rare

Abnormal or decreased touch sensation

agitation

blood in the urine

blurred vision

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

chest pain or discomfort

chills

cold sweats

coma

confusion

decreased urine output

depression

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

fainting

headache

hostility

irritability

lethargy

muscle twitching

nausea

seizures

shakiness in the legs, arms, hands, or feet

slow or irregular heartbeat

stupor

sweating

trembling or shaking of the hands or feet

unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Difficulty having a bowel movement (stool)

Less common

Dry mouth

stomach pain

Rare

Lack or loss of strength

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Sarah Pearson is a practicing pharmacist with over 10 years of experience in the field. She received her doctorate in pharmacy from the University of Georgia in Athens, GA.
Kristianne Hannemann, PharmD, is a licensed pharmacist in California. She has been a retail pharmacy manager and staff pharmacist for over 7 years and has contributed drug information content to different health companies.

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