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Phenoxybenzamine Coupon - Phenoxybenzamine 10mg capsule

phenoxybenzamine

Generic Dibenzyline
Used for Hypertension
Used for Hypertension

Phenoxybenzamine (Dibenzyline) is used to treat a condition called pheochromocytoma. It's taken by mouth, typically 2-4 times a day. But it's not meant for long-term use. Side effects of phenoxybenzamine (Dibenzyline) include low blood pressure when standing from a sitting position, fast heart rate, and stuffy nose. It's available as a brand-name capsule and also as a lower-cost generic.

Reviewed by:
reviewer
Robert Chad Hakim, PharmD, BCCCP
reviewer
Allison Gourley, PharmD
Last reviewed on June 12, 2023
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageInteractionsCostContraindicationsImagesReferencesPricesMedicare
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What is Phenoxybenzamine (Dibenzyline)?

What is Phenoxybenzamine (Dibenzyline) used for?

How Phenoxybenzamine (Dibenzyline) works

Phenoxybenzamine (Dibenzyline) is a non-selective alpha blocker. By blocking alpha receptors, phenoxybenzamine (Dibenzyline) prevents certain chemicals (called catecholamines) from binding to these receptors. This helps to relax your blood vessels, lower your blood pressure, and lessen sweating from pheochromocytoma.

Drug Facts

Common BrandsDibenzyline
Drug ClassAlpha blocker
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
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What are the side effects of Phenoxybenzamine (Dibenzyline)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Dizziness
  • Sleepiness
  • Stuffy nose
  • Upset stomach
  • Small pupils
  • Trouble ejaculating
  • Pounding heart (fast heart rate)

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Dangerously low blood pressure: dizziness, lightheadedness, pale skin, feeling faint

Source: DailyMed

The following side effects have also been reported

In rats and mice, phenoxybenzamine has been found to increase the risk of development of malignant tumors. It is not known if phenoxybenzamine increases the chance of tumors in humans.

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Dizziness or lightheadedness, especially when getting up from a lying or sitting position

fast heartbeat

pinpoint pupils

stuffy nose

Less common

Confusion

drowsiness

dryness of mouth

headache

lack of energy

sexual problems in males

unusual tiredness or weakness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Phenoxybenzamine (Dibenzyline)

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Pros

Works well to treat high blood pressure and sweating from pheochromocytoma

Taken by mouth

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Cons

Taken 2 to 4 times per day

Can't be used long-term because of the risk of cancer

pharmacist-tips

Pharmacist tips for Phenoxybenzamine (Dibenzyline)

pharmacist

  • Mark your calendar with your appointments to see your provider during treatment with phenoxybenzamine (Dibenzyline). This is to make sure phenoxybenzamine (Dibenzyline) is working well and is as safe as possible for you.

    • Taking phenoxybenzamine (Dibenzyline) can raise your heart rate. If you notice your heart rate is going up after starting this medication or if you feel a pounding heart, talk with your provider. If appropriate, they prescribe a beta blocker to help slow your heart rate.

      • You might feel dizzy when you start taking phenoxybenzamine (Dibenzyline) and when your provider raises your dose. This side effect should lessen over time as you continue taking the medication and your body gets used to your new blood pressure.

        • Phenoxybenzamine (Dibenzyline) can make you sleepy and affect your ability to think, react, and focus. Don't drive or do activities where you need to focus until you know how this medication affects you. Also, don't drink alcohol because it can worsen sleepiness and dizziness.

          faqs

          Frequently asked questions about Phenoxybenzamine (Dibenzyline)

          Why is phenoxybenzamine (Dibenzyline) used for pheochromocytoma?
          Pheochromocytoma is a type of tumor on the adrenal glands. The adrenal gland normally releases chemicals called catecholamines (e.g., dopamine, norepinephrine, and epinephrine). These chemicals are normally released to help a person respond in stressful situations, also known as the fight or flight response. When these chemicals bind to their receptors, they raise blood pressure, heart rate, rate of breathing, mental alertness, and sweating. People with pheochromocytoma release too much of these chemicals, which causes symptoms like headaches, high blood pressure, heart rhythm changes, and sweating. Phenoxybenzamine (Dibenzyline) helps by preventing catecholamines from binding to alpha receptors throughout the body. This helps to treat high blood pressure and sweating from pheochromocytoma.
          Does phenoxybenzamine (Dibenzyline) cause diarrhea?
          Yes, it's possible for phenoxybenzamine (Dibenzyline) to cause diarrhea. If you get diarrhea after starting phenoxybenzamine (Dibenzyline), talk with your provider. If appropriate, they can recommend over-the-counter treatment options for you to consider, such as loperamide (Imodium A-D) or bismuth subsalicylate (Pepto-Bismol). Make sure to stay hydrated by drinking oral rehydration solutions, like Pedialyte. If your diarrhea lasts for longer than 2 days or if you also develop a fever, get medical help.
          How long does it take for phenoxybenzamine (Dibenzyline) to start working?
          Phenoxybenzamine (Dibenzyline) starts to work within several hours.
          Can I take phenoxybenzamine (Dibenzyline) if I'm pregnant?
          Have a discussion with your provider before starting phenoxybenzamine (Dibenzyline) if you're pregnant. There haven't been strong enough studies to know for sure how safe phenoxybenzamine (Dibenzyline) is to take during pregnancy. Some case reports of people who took phenoxybenzamine (Dibenzyline) short-term during pregnancy didn't experience harm from the medication. Based on the reports, phenoxybenzamine (Dibenzyline) might be prescribed for pregnant females with pheochromocytoma and high blood pressure if the benefit is greater than the risk of harm.
          Can I take phenoxybenzamine (Dibenzyline) if I'm breastfeeding?
          It's not known whether or not phenoxybenzamine (Dibenzyline) gets into breastmilk because it hasn't been studied. Because of the potential risk for side effects in nursing babies, it's generally recommended to not breastfeed while taking phenoxybenzamine (Dibenzyline).
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          What are the risks and warnings for Phenoxybenzamine (Dibenzyline)?

          Phenoxybenzamine (Dibenzyline) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

          risk-warning

          Drop in blood pressure upon standing

          • Risk factors: Taking medications for high blood pressure, chest pain, or erectile dysfunction | History of low blood pressure or a drop in blood pressure after taking other medications

            Phenoxybenzamine (Dibenzyline) can cause a drop in blood pressure when you stand up from a seated or lying down position. This might make you feel dizzy or it can cause you to faint. Your risk is higher if you're also taking other blood pressure medications or erectile dysfunction medications at the same time. Be cautious with your activities when you first start phenoxybenzamine (Dibenzyline) or when your provider raises your dose.

            risk-warning

            Medication interactions

            Phenoxybenzamine (Dibenzyline) blocks alpha receptors in your body to lower your blood pressure. It can interact with certain medications that activates the same receptors to work. For example, one of the ways epinephrine (Epipen) works to treat a serious allergic reaction is to act on your alpha receptors to raise blood pressure. But if you're taking phenoxybenzamine (Dibenzyline), it can prevent epinephrine (Epipen) from working well. Before you start phenoxybenzamine (Dibenzyline), ask your provider or pharmacist to check to see if there might be any interactions with your current medications.

            risk-warning

            Not for long-term use (risk of cancer)

            Phenoxybenzamine (Dibenzyline) isn't meant for long-term use. There have been a few reports of people developing cancer after taking phenoxybenzamine (Dibenzyline) for a long time. Ask your provider how long should receive treatment with this medication.

            dosage

            Phenoxybenzamine (Dibenzyline) dosage forms

            The average cost for 60 capsules of 10mg of Phenoxybenzamine (Dibenzyline) is $597.30 with a free GoodRx coupon. This is 91.39% off the average retail price of $6940.30.
            capsule
            Capsule
            DosageQuantityPrice as low asPrice per unit
            10mg60 capsules$597.30$9.95

            Typical dosing for Phenoxybenzamine (Dibenzyline)

            The typical starting dose is 10 mg by mouth twice per day. The typical maintenance dose ranges from 20 mg to 40 mg two or three times a day based on how well you're responding to the medication and if you're having side effects.

            interactions

            Interactions between Phenoxybenzamine (Dibenzyline) and other drugs

            Phenoxybenzamine (Dibenzyline) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Phenoxybenzamine (Dibenzyline). Please note that only the generic name of each medication is listed below.

            Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

            Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

            drug-cost

            How much does Phenoxybenzamine (Dibenzyline) cost?

            To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
            Dibenzyline (brand)
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            $597.30

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            Phenoxybenzamine (Dibenzyline) (generic)
            GoodRx lowest price

            $597.30

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            contraindications-icon

            Phenoxybenzamine (Dibenzyline) contraindications

            Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Phenoxybenzamine (Dibenzyline) will not be safe for you to take.

            • Medical conditions where a drop in blood pressure isn't desired

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            Phenoxybenzamine (Dibenzyline) images

            Red 365 Novitium 10 Mg - Phenoxybenzamine Hydrochloride 10mg Capsule
            This medicine is Red Capsule Imprinted With "365 Novitium 10 Mg".Red 365 Novitium 10 Mg - Phenoxybenzamine Hydrochloride 10mg Capsule

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            References

            Best studies we found

            Aurobindo Pharma Limited. (2023). Phenoxybenzamine hydrochloride capsule [package insert]. DailyMed.

            Farzam, K., et al. (2023). Adrenergic drugs. StatPearls.

            Nachawati, D., et al. (2023). Alpha-blockers. StatPearls.

            View All References (7)

            National Cancer Institute. (2020). Pheochromocytoma.

            National Cancer Institute. (n.d.). Fight-or-flight syndrome.

            Oliva, R., et al. (2010). Pheochromocytoma in pregnancy: A case series and review. Hypertension.

            Paravati, S., et al. (2022). Physiology, catecholamines. StatPearls.

            ScienceDirect. (n.d.). Phenoxybenzamine.

            Yoham, A. L., (2023). Phenoxybenzamine. StatPearls.

            You and Your Hormones. (2021). Adrenal glands.

            GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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