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Orgovyx Coupon - Orgovyx 120mg tablet

Orgovyx

relugolix
Used for Prostate Cancer
Used for Prostate Cancer

Orgovyx (relugolix) is used to treat advanced prostate cancer. It’s a hormonal therapy called a luteinizing hormone-releasing hormone (LHRH) antagonists that works by lowering the amount of testosterone in your body. Orgovyx (relugolix) is convenient because it’s a tablet that you take by mouth once daily. But it can cause hot flashes as a side effect, which can be bothersome.

Last reviewed on March 28, 2024
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What is Orgovyx (relugolix)?

What is Orgovyx (relugolix) used for?

How Orgovyx (relugolix) works

Orgovyx (relugolix) is a LHRH antagonist. It blocks a natural hormone in your brain called LHRH that typically releases testosterone. When LHRH is lower, this lowers the amount of testosterone in your body.

Testosterone causes most prostate cancer cells to grow. So, when Orgovyx (relugolix) causes less testosterone in your body, prostate cancer cells can’t grow or spread as well.

Drug Facts

Common BrandsOrgovyx
Drug ClassLuteinizing hormone-releasing hormone (LHRH) antagonist
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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What are the side effects of Orgovyx (relugolix)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Other Side Effects

  • Weight gain
  • Trouble sleeping
  • Lower sex drive
  • Development of breasts (gynecomastia)
  • Sweating more
  • Depression

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Stroke: sudden weakness on one side of your body, drooping face, headache, changes in your speech or vision, confusion
  • Heart attack: chest pain, arm pain, shortness of breath, cold sweat

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Orgovyx (relugolix)

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Pros

Oral pill, so it doesn’t require an injection

Taken once a day

Doesn't cause testosterone flares (so no risk for related symptoms, such as bone pain)

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Cons

Brand-name medication only

Can raise blood sugar levels

Can make you feel very tired

pharmacist-tips

Pharmacist tips for Orgovyx (relugolix)

pharmacist
  • You can take Orgovyx (relugolix) with or without food. Take the medication at the same time each day. Swallow the tablet whole. Don’t chew, crush, or split the tablet.

    • If you miss a dose of Orgovyx (relugolix), take it as soon as you remember. But if it’s been more than 12 hours since the time you normally take your dose, skip that dose. Take your next dose at your normally scheduled time. Don’t take two doses at once.

      • Let your oncologist know if you miss your Orgovyx (relugolix) doses multiple days in row so they're aware and can give you advice for any next-steps. If you miss more than 7 days in a row, you'll need to restart your treatment by taking the one-time loading dose first.

        • Certain medications, like erythromycin or rifampin (Rifadin), can interact with Orgovyx (relugolix). When these medications are taken with Orgovyx (relugolix), it can change the levels of Orgovyx (relugolix) in your body. This can affect how well Orgovyx (relugolix) works to treat your cancer or raise your risk of side effects. Tell your oncologist and pharmacist about all the medications you take, including supplements and over-the-counter medications.

          • Orgovyx (relugolix) can raise the levels of blood sugar and fat (triglycerides) in your body. Because you might not experience any symptoms from these side effects, your oncologist might order blood tests to monitor your blood sugar and fat levels.

            • It’s possible for Orgovyx (relugolix) to cause birth defects or pregnancy in your female partners. If your partner is able to become pregnant, make sure to use birth control, such as condoms or birth control pills, while you’re taking and for 2 weeks after your last dose of Orgovyx (relugolix). Talk with your oncologist if you have questions about birth control options for you and your partner.

              • Ask your care team about the best way to handle and dispose of Orgovyx (relugolix). Anticancer medications can be very harmful to people who handle or come into contact with them, so you need to get rid of them safely.

                faqs

                Frequently asked questions about Orgovyx (relugolix)

                Is Orgovyx (relugolix) a kind of chemotherapy?
                Orgovyx (relugolix) is not a chemotherapy medication. Chemotherapy is a class of medication that targets and kills fast-growing cells in your body, including cancer cells.Orgovyx (relugolix) doesn’t kill cancer cells. Instead, it’s a form of hormonal therapy called a LHRH antagonist. It works by lowering the amount of the male sex hormone (testosterone) in your body. Most prostate cancer cells need testosterone to grow and spread. By lowering testosterone, Orgovyx (relugolix) lowers the “fuel” cancer cells need to grow or spread.
                How long do I need to take Orgovyx (relugolix) for?
                You should take Orgovyx (relugolix) as instructed by your oncologist. How long you take Orgovyx (relugolix) depends on several factors, including how well the medication is working to lower your testosterone and how well you tolerate side effects. It can also depend on how your oncologist decides to use the medication. Don’t stop taking Orgovyx (relugolix) without first discussing with your oncologist.
                How long does Orgovyx (relugolix) stay in your system?
                Once you stop taking Orgovyx (relugolix), it takes over 2 weeks for most of this medication to leave your system. Keep in mind that this timeframe is estimated based on the half-life of this medication. It might differ from person to person, depending on what other medications they're taking and what other health conditions they have.
                Does Orgovyx (relugolix) cure prostate cancer?
                Orgovyx (relugolix) itself doesn’t cure prostate cancer. It’s approved to be used in advanced prostate cancer that has already spread. This means it’s typically not possible to completely get rid of all of your prostate cancer cells. Additionally, Orgovyx (relugolix) works to lower testosterone in your body, which means it lowers the “fuel” to prostate cancer cells. So, Orgovyx (relugolix) itself doesn’t kill cancer cells. Instead, it works to prevent them from growing and spreading as well.
                How do I manage hot flashes from Orgovyx (relugolix)?
                Hot flashes are a common side effect of Orgovyx (relugolix). Let your oncologist know if you experience hot flashes while taking Orgovyx (relugolix) and they can suggest ways to help you manage this side effect both with and without medications. Medications that can ease your hot flashes include estrogens, progestin, antidepressants, and anticonvulsants. But these medications can cause additional side effects that you might find bothersome, including nausea, tiredness, or dizziness. If you want to avoid medications, you can try relaxation techniques, breathing exercises, behavioral therapy, and hypnosis, to cope with hot flashes. You can also try wearing loose-fitting clothing or using fans to keep you cool.
                Will taking Orgovyx (relugolix) impact my sex life?
                Yes, it's possible for Orgovyx (relugolix) to lower your sex drive. Orgovyx (relugolix) lowers testosterone in your body. Some males with lower testosterone might experience a lower sex drive or erectile dysfunction. Talk to your oncologist if you have concerns about the effects of Orgovyx (relugolix) on your sex life. If appropriate, they might prescribe you medications like sildenafil (Viagra) or tadalafil (Cialis), to help with some of these symptoms.
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                What are the risks and warnings for Orgovyx (relugolix)?

                Orgovyx (relugolix) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                risk-warning

                Changes in heart rhythm

                • Risk factors: Long QT syndrome | Heart failure | Low electrolyte levels

                  Taking Orgovyx (relugolix) can cause changes in your heart rhythm (long QT syndrome), which can cause your heart to not beat like it should. Your oncologist might monitor your blood levels of certain electrolytes that affect your heart, such as potassium. They might also perform an electrocardiogram (ECG) to check your heart rhythms. Let your oncologist know if you experience dizziness, fainting, chest pain, or a fast heartbeat. These can be symptoms of a change in your heart rhythm.

                  risk-warning

                  Harm to unborn baby

                  Orgovyx (relugolix) hasn’t been well studied in human pregnancies, but animal studies show that it can harm in unborn babies and raise the risk for miscarriage (pregnancy loss). Because of these risks, if you have a female partner who’s able to become pregnant, please discuss with them about possible birth control options while you’re taking Orgovyx (relugolix) and for at least 2 weeks after your last dose. Your partner should tell their healthcare team right away if they become pregnant during this time so that their team can check on their health and the health of their baby.

                  dosage

                  Orgovyx (relugolix) dosage forms

                  Typical dosing for Orgovyx (relugolix)

                  The typical starting dose is 360 mg by mouth as a one-time loading dose on the first day of treatment. After that, the typical maintenance dose is 120 mg by mouth once daily.

                  Your dose might be different if you take certain medications that might interact with Orgovyx (relugolix).

                  alternatives

                  What are alternatives to Orgovyx (relugolix)?

                  There are a number of medications that your doctor can prescribe in place of Orgovyx (relugolix). Compare a few possible alternatives below.
                  Orgovyx (relugolix)
                  Used for:
                  Used for:
                  • Advanced prostate cancer

                  images

                  Orgovyx (relugolix) images

                  Red Oblong R And 120 - ORGOVYX 120mg Tablet
                  This medicine is Red, Oblong Tablet Imprinted With "R" And "120".Red Oblong R And 120 - ORGOVYX 120mg Tablet

                  References

                  Best studies we found

                  Nassar, G. N., et al. (2023). Physiology, testosterone. StatPearls.

                  National Cancer Institute. (2021). Hot flashes and night sweats (PDQ®)–Patient version.

                  National Comprehensive Cancer Network. (2024). Advanced-stage prostate cancer.

                  View All References (3)

                  Shore, N. D., et al. (2020). Oral relugolix for androgen-deprivation therapy in advanced prostate cancer. The New England Journal of Medicine.

                  Sumitomo Pharma America, Inc. (2024). Orgovyx- relugolix tablet, film coated [package insert]. DailyMed.

                  Vandeven, H. A., et al. (2023). Gynecomastia. StatPearls.

                  GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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