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Nizatidine Coupon - Nizatidine 150mg capsule

nizatidine

Generic Axid
Used for Heartburn, Gastric Ulcer, GERD, Duodenal Ulcer
Used for Heartburn, Gastric Ulcer, GERD, Duodenal Ulcer

Nizatidine is an H2 blocker that lowers the amount of stomach acid. It's used to treat adults with conditions such as ulcers and heartburn due to gastroesophageal reflux disease (GERD). It comes as an oral capsule that's taken by mouth once or twice a day. The brand name Axid has been discontinued, but it's still available as a generic. It's currently not available over the counter, so you'll need a prescription from a healthcare professional to take this medication. Headache and diarrhea are some potential side effects.

Reviewed by:
reviewer
Kristianne Hannemann, PharmD
reviewer
Daisy Chau, PharmD
Last reviewed on October 6, 2024
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageInteractionsCostContraindicationsAlternativesLatest newsImagesReferencesPricesMedicare
basics-icon

What is Nizatidine?

What is Nizatidine used for?

How Nizatidine works

Nizatidine is a histamine H2 antagonist, or H2 blocker. It blocks your stomach from releasing acid, which prevents heartburn and helps heal ulcers.

Drug Facts

Common BrandsAxid (brand name no longer available)
Drug ClassHistamine H2 antagonist
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
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What are the side effects of Nizatidine?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Headache (17%)
  • Runny nose (10%)
  • Stomach pain (8%)
  • Diarrhea (7%)
  • Dizziness (5%)
  • Nausea (5%)
  • Passing gas (5%)

Other Side Effects

  • Pain
  • Vomiting
  • Constipation
  • Trouble sleeping
  • Weakness
  • Infection
  • Fever
  • Dry mouth
  • Abnormal dreams
  • Loss of appetite
  • Sleepiness
  • Cough
  • Rash
  • Itchiness

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Serious allergic reaction: rash, swelling of the face or throat, trouble breathing

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Rare

Abdominal pain

back, leg, or stomach pain

bleeding or crusting sores on lips

blistering, burning, redness, scaling, or tenderness of skin

blisters on palms of hands and soles of feet

changes in vision or blurred vision

confusion

coughing or difficulty in swallowing

dark-colored urine

dizziness

fainting

fast, pounding, or irregular heartbeat

fever and/or chills

flu-like symptoms

general feeling of discomfort or illness

hives

inflammation of blood vessels

joint pain

light-colored stools

mood or mental changes, including anxiety, agitation, confusion, hallucinations (seeing, hearing, or feeling things that are not there), mental depression, nervousness, or severe mental illness

muscle cramps or aches

nausea, vomiting, or loss of appetite

pain

peeling or sloughing of skin

red or irritated eyes

shortness of breath

skin rash or itching

slow heartbeat

sore throat

sores, ulcers, or white spots on lips, in mouth, or on genitals

sudden difficult breathing

swelling of face, lips, mouth, tongue, or eyelids

swelling of hands or feet

swollen or painful glands

tightness in chest

troubled breathing

unusual bleeding or bruising

unusual tiredness or weakness

unusually slow or irregular breathing

wheezing

yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common or rare

Constipation

decrease in sexual desire

decreased sexual ability (especially in patients with Zollinger-Ellison disease who have received high doses of cimetidine for at least 1 year)

diarrhea

difficult urination

dizziness

drowsiness

dryness of mouth or skin

headache

increased or decreased urination

increased sweating

loss of hair

ringing or buzzing in ears

runny nose

swelling of breasts or breast soreness in females and males

trouble in sleeping

Not all of the side effects listed above have been reported for each of these medicines, but they have been reported for at least one of them. All of the H2-blockers are similar, so any of the above side effects may occur with any of these medicines.

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Nizatidine

thumbs-up

Pros

Typically taken by mouth once or twice a day

Comes in two different strengths

Can treat many conditions related to too much stomach acid

thumbs-down

Cons

Not as strong as other acid-lowering medications like proton pump inhibitors (PPIs)

Not approved for children

Common side effects include headache and diarrhea

pharmacist-tips

Pharmacist tips for Nizatidine

pharmacist

  • If you're only taking nizatidine once a day, make sure you take it at bedtime. The medication can block nighttime stomach acid for up to 12 hours.

    • You can take nizatidine with or without food. If the medication upsets your stomach, try taking it with food to help.

      • Nizatidine is usually used short-term, for a few months to treat an ulcer. But you might need to take it longer to keep the ulcer from coming back. Take the medication as directed by your prescriber.

        • Headache is a common side effect of nizatidine. Let your prescriber know if headaches become bothersome. They might recommend tips on how to provide relief.

          faqs

          Frequently asked questions about Nizatidine

          Does nizatidine cause cancer?
          A recent study didn't find evidence of nizatidine causing a higher risk of cancer. A chemical called N-nitrosodimethylamine (NDMA), a nitrosamine that's linked to cancer, has been found in some medications, including some forms of nizatidine. The FDA works with manufacturers to make sure nitrosamine levels, including NDMA, remain below safe limits. Talk to your prescriber if you want more information about this.
          Can you take nizatidine and omeprazole together?
          Yes, it's possible to take nizatidine and omeprazole (Prilosec) together. They work in different ways to lower the acid in your stomach. But there are also risks and side effects of omeprazole (Prilosec) that you should know about. Before taking any other medications, talk to your care team first.
          How long does nizatidine take to work?
          Nizatidine prevents stomach acid from being released within an hour. If you're taking nizatidine for a duodenal ulcer, those will usually heal within 4 weeks of taking the medication.
          Why is nizatidine taken at night?
          If you're taking nizatidine once a day, it's recommended to take it at bedtime. This medication can work by blocking stomach acid overnight. Additionally, some people experience worse heartburn at night when they're lying down. Taking nizatidine at night can help reduce the amount of acid produced, which can relieve your symptoms.
          Has nizatidine been discontinued?
          No, nizatidine hasn't been discontinued. There used to be an oral solution that isn't available anymore, but you can still get the capsules with a prescription.
          Is nizatidine over the counter?
          No, nizatidine isn't currently available over the counter. You can still get the medication with a prescription from your healthcare professional.
          Does nizatidine cause weight gain?
          Weight gain wasn't reported as a side effect during clinical studies of nizatidine. In general, it shouldn't cause weight gain, but if you notice any changes in your weight, let your care team know. They can help you determine the cause of the weight gain.
          Is nizatidine the same as ranitidine?
          No. Nizatidine isn't the same as ranitidine (previously known as Zantac), but they're similar. They belong in the same medication class and both lower the amount of acid in your stomach. Ranitidine (Zantac) is no longer available in the U.S., so nizatidine can be a good replacement option.
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          What are the risks and warnings for Nizatidine?

          Nizatidine can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

          risk-warning

          Symptoms that don't go away or come back

          Sometimes heartburn, GERD, and other upset stomach symptoms can be signs of serious stomach problems or cancer. And medications like nizatidine can hide these symptoms. Talk to your prescriber if your stomach symptoms don't completely go away with nizatidine or if your symptoms come back really fast after stopping the medication. You might need to undergo testing to see if you have a more serious problem.

          risk-warning

          Higher risk of side effects in people with kidney problems

          • Risk factors: Older adults | History of kidney problems

            Your body gets rid of nizatidine through your urine. If you have kidney problems, you might have a buildup of medication, which can lead to more side effects. This is especially true for people who're older adults with poor kidney function. Your prescriber might want to monitor your kidney labs to make sure you're taking the appropriate dose of this medication.

            dosage

            Nizatidine dosage forms

            The average cost for 60 capsules of 150mg of Nizatidine is $27.60 with a free GoodRx coupon. This is 78.65% off the average retail price of $129.26.
            capsule
            Capsule
            DosageQuantityPrice as low asPrice per unit
            150mg60 capsules$27.60$0.46
            300mg30 capsules$26.56$0.89
            ml of oral solution
            Ml of oral solution
            DosageQuantityPrice as low asPrice per unit
            15mg/ml40 ml$27.07$0.68

            Typical dosing for Nizatidine

            • Duodenal (small intestine) ulcer: The typical dose is 300 mg by mouth once a day at bedtime OR 150 mg twice a day. After the ulcer has healed, the dose usually goes down to 150 mg once a day at bedtime.

            • Gastric (stomach) ulcer: The typical dose is 300 mg by mouth once a day at bedtime OR 150 mg twice a day.

            • Esophagitis and heartburn due to GERD: The typical dose is 150 mg by mouth twice a day.

            Your dose might be different if you have kidney problems.

            interactions

            Interactions between Nizatidine and other drugs

            Nizatidine may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Nizatidine. Please note that only the generic name of each medication is listed below.

            Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking any of these medicines, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

            Using medicines in this class with any of the following medicines is not recommended. Your doctor may decide not to treat you with a medication in this class or change some of the other medicines you take.

            Using medicines in this class with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

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            How much does Nizatidine cost?

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            contraindications-icon

            Nizatidine contraindications

            Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Nizatidine will not be safe for you to take.

            • Severe allergy to other H2 blockers

            alternatives

            What are alternatives to Nizatidine?

            There are a number of medications that your doctor can prescribe in place of Nizatidine. Compare a few possible alternatives below.
            Nizatidine
            Used for:
            $26.56 Lowest GoodRx priceView Prices
            Famotidine (Pepcid AC)
            Used for:

            • Prevention and treatment of heartburn (gastroesophageal reflux disease or GERD)

            $6.60 Lowest GoodRx priceView Prices
            Cimetidine (Tagamet HB)
            Used for:
            $30.92 Lowest GoodRx priceView Prices
            images

            Nizatidine images

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            References

            Best studies we found

            Actavis Pharma, Inc. (2022). Nizatidine capsule [package insert]. DailyMed.

            Antunes, C., et al. (2023). Esophagitis. StatPearls.

            Iwagami, M., et al. (2021). Risk of cancer in association with ranitidine and nizatidine vs other H2 blockers: Analysis of the Japan Medical Data Center Claims Database 2005–2018. Drug Safety.

            View All References (5)

            Katz, P. O., et al. (2022). ACG clinical guideline for the diagnosis and management of gastroesophageal reflux disease. The American Journal of Gastroenterology.

            Kovacs, T. O., et al. (1987). The effect of an oral evening dose of nizatidine on nocturnal and peptone-stimulated gastric acid and gastrin secretion. Scandinavian Journal of Gastroenterology. Supplement.

            Nugent, C. C., et al. (2024). H2 blockers. StatPearls.

            U.S. Food and Drug Administration. (2020). FDA updates and press announcements on NDMA in Zantac (ranitidine).

            U.S. Food and Drug Administration. (2024). Information about nitrosamine impurities in medications.

            GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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