Prodrin
Prodrin is a combination medication used to treat tension and vascular headaches. It's no longer available in the U.S. because it was discontinued.
What is Prodrin?
Drug facts
Common questions about Prodrin
Prodrin is a combination of three medications. Isometheptene and caffeine narrow the blood vessels that are responsible for headaches, while acetaminophen helps to relieve the pain from headaches.
Prodrin is no longer available in the United States.
Prodrin contains isometheptene, which has been on the market for a very long time, since the time when the FDA approved medications only based on safety, and not effectiveness. In 1962, the law was changed and new medications were only approved if they were found to be safe and effective. Because the isometheptene in Prodrin was on the market prior to this change in the law, this medication was "grandfathered" in and allowed to stay on the market. But in 2017, the FDA notified manufacturers to stop distributing their medications that contained isometheptene, which includes Prodrin. Manufacturers would need to have a new drug application approved if they want to re-distribute this medication.
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