Exelderm (sulconazole) is an antifungal medication that works well to treat adults with common fungal skin infections like athlete's foot, jock itch and ringworm. It comes as a cream and topical solution that you apply to the affected area(s) once or twice a day. Side effects aren't common, but can include itching, burning, and stinging. The medication is available in brand and generic versions.
Athlete's foot - cream only
Tinea versicolor (fungal skin infection that causes skin color changes)
Exelderm (sulconazole) is an antifungal. It works by stopping the fungus from making a substance it needs for its protective outer covering. This prevents it from growing and spreading in the body.
Source: DailyMed
Side effects that you should report to your care team as soon as possible:
Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
Generally well tolerated with few side effects
Available as a topical cream and solution
Can be used once or twice a day
Can cause itching, burning, or stinging
Can be messy to apply
Not known whether it's safe to use for children
Apply a thin layer of Exelderm (sulconazole) to the affected areas on your skin, and rub it in gently and thoroughly. Be sure to also apply this medication to the areas just around the infection to make sure you've covered everything.
Wash your hands with soap and water after using Exelderm (sulconazole) to prevent it from getting in your eyes, unless you're treating your hands. If the medication gets in your eyes, rinse them well with water.
Don't cover the areas where Exelderm (sulconazole) is applied with bandages or dressings unless your prescriber tells you to. Usually, you want your skin to be able to breathe and stay dry if it has a fungal infection.
Use Exelderm (sulconazole) for the full recommended time (4 weeks for athlete's foot or 3 weeks for other conditions). Don't stop using it early, even if your symptoms improve. Stopping too soon can make your condition more likely to return.
Let your prescriber know if your symptoms don't improve after the recommended treatment time with Exelderm (sulconazole). You might need a different antifungal treatment, or your condition could be caused by something else.
Tell your care team if you're pregnant or breastfeeding. It isn't known how safe Exelderm (sulconazole) is to use in these situations.
Exelderm (sulconazole) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Only use Exelderm (sulconazole) on the skin. It shouldn't be used in the eyes, so be careful when applying it on your face. If it gets in your eye, rinse it out with water right away.
Athlete's foot (cream only): Apply to the affected area(s) twice daily for 4 weeks.
Jock itch, body ringworm, and tinea versicolor: Apply to the affected area(s) once or twice daily for 3 weeks.
Athlete's foot - cream only
Tinea versicolor (fungal skin infection that causes skin color changes)
Athlete's foot (tinea pedis) between the toes
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Herrick, E. J., et al. (2024). Antifungal ergosterol synthesis inhibitors. StatPearls.
Journey Medical Corporation. (2022). Exelderm- sulconazole nitrate solution [package insert]. DailyMed.
Ludmann, P. (2024). Seborrheic dermatitis: Diagnosis and treatment. American Academy of Dermatology Association.
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