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Epogen

Epogen Side Effects

Kristianne Hannemann, PharmDDaisy Chau, PharmD
Reviewed by Kristianne Hannemann, PharmD, Daisy Chau, PharmD
Last reviewed on July 1, 2025

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Chronic kidney disease (CKD)

  • High blood pressure (up to 28%)
  • Joint pain (up to 16%)
  • Fever (10%)
  • Dizziness (10%)

Taking zidovudine for HIV

  • Fever (42%)
  • Cough (26%)
  • Rash (19%)

Cancer chemotherapy

  • Nausea (35%)
  • Vomiting (20%)
  • Muscle pain (10%)
  • Joint pain (10%)
  • Mouth sores (10%)

Certain surgeries

  • Nausea (up to 56)
  • Vomiting (up to 28%)
  • Itchiness (up to 21%)
  • Headache (up to 18%)
  • Injection-site pain (up to 13%)

Less Common Side Effects

Chronic kidney disease (CKD)

  • Muscle spasm
  • Upper respiratory tract infection

Taking zidovudine for HIV

  • Injections-site irritation
  • Hives
  • Congestion

Cancer chemotherapy

  • Cough
  • Weight loss
  • Low white blood cell count
  • Bone pain
  • Rash
  • High blood sugar
  • Trouble sleeping
  • Headache
  • Depression
  • Difficulty swallowing

Certain surgeries

  • Chills
  • Cough
  • High blood pressure
  • Rash
  • Swelling

Epogen serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Blood clot: pain in the legs, cool or pale arm or leg, sudden trouble seeing, chest pain, trouble breathing
  • Heart attack: chest pain, shortness of breath, sweating, dizziness
  • Stroke: sudden weakness in arms or legs, difficulty speaking, trouble understanding speech, sudden confusion, balance problems, trouble walking, fainting
  • Severe allergic reaction: rash, itching, shortness of breath, wheezing, dizziness, fainting, facial swelling, fast pulse, sweating
  • Serious skin reactions: itchy rash, blisters, skin sores, peeling
  • Seizures

Source: DailyMed

The following Epogen side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Chest pain

fever

headache

increased blood pressure

swelling of the face, fingers, ankles, feet, or lower legs

weight gain

Less common

Anxiety

blurred vision

change in skin color

change in vision

cough

dizziness or lightheadedness

double vision

fainting

fast heartbeat

migraine headache

nausea

pain or discomfort in the arms, jaw, back, or neck

pain, tenderness, or swelling of the foot or leg

pain in the chest, groin, or legs, especially calves of the legs

pale skin

partial or complete loss of vision in the eye

seizures

severe headache of sudden onset

skin rash or hives

slurred speech

sore throat

sudden and severe inability to speak

sudden loss of coordination

sweating

temporary blindness

tenderness, pain, swelling, warmth, or skin discoloration at the injection site

unusual bleeding or bruising

unusual tiredness or weakness

vision problems

vomiting

weakness in the arm or leg on one side of the body, sudden and severe

Incidence not known

Blistering, peeling, or loosening of the skin

chills

diarrhea

itching

joint or muscle pain

red, irritated eyes

red skin lesions, often with a purple center

sore throat

sores, ulcers, or white spots in the mouth or on the lips

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Bone or joint pain

constipation

general feeling of tiredness or weakness

heartburn or belching

itching or stinging at the injection site

loss of strength or energy

muscle aches or weakness

shivering

skin pain

stomach discomfort, upset, pain, or swelling

weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Kristianne Hannemann, PharmD, is a licensed pharmacist in California. She has been a retail pharmacy manager and staff pharmacist for over 7 years and has contributed drug information content to different health companies.
Daisy Chau, PharmD
Reviewed by:
Daisy Chau, PharmD
Daisy Chau, PharmD, is the drug information pharmacist manager at GoodRx. She is licensed in California and has more than 6 years of experience working as a pharmacist in drug information.

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