Key takeaways
Methazolamide and Cosopt (dorzolamide/timolol) are both used to lower eye pressure, but they have some key differences. Methazolamide is an oral tablet taken 2 or 3 times a day, while Cosopt is an eye drop used twice a day. Methazolamide is a carbonic anhydrase inhibitor, whereas Cosopt combines a carbonic anhydrase inhibitor (dorzolamide) with a beta blocker (timolol). Methazolamide is available only as a generic, while Cosopt is available in both brand name and generic forms. Methazolamide can cause side effects such as tingling in the arms or legs, stomach upset, and taste changes. Blurry vision and changes in taste are a couple of examples of Cosopt side effects. Additionally, Cosopt is not recommended for people with asthma or severe heart conditions, whereas methazolamide should be used cautiously in people with liver or kidney problems.
