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Filspari vs. Tarpeyo

Filspari (sparsentan) is a medication that works well to lower urine protein levels in people with immunoglobulin A nephropathy (IgAN). It's not known if this means Filspari (sparsentan) slows down worsening kidney function, but this is something that's currently being studied. Filspari (sparsentan) is taken by mouth, typically once daily. Some of the more common side effects it can cause include swelling in the arms and legs, low blood pressure, and dizziness.

• Lower urine protein levels in adults with immunoglobulin A nephropathy (IgAN)

• Swelling in arms or legs (14%)
• Low blood pressure (14%)
• Dizziness (13%)
• High blood potassium levels (13%)

• Serious liver damage
• Not for use during pregnancy
• Dangerously low blood pressure
• Serious kidney damage
• High potassium levels
• Too much fluid

Tarpeyo, the brand name for budesonide delayed-release capsules, is a corticosteroid. It helps lessen the worsening of kidney function in adults with a kidney condition called immunoglobulin A nephropathy (IgAN). Tarpeyo (budesonide) is taken by mouth once daily in the morning on an empty stomach. Some possible side effects include swelling in the arms and legs, high blood pressure, and weight gain.

• Lessening the worsening of kidney function in adults with a kidney condition called immunoglobulin A nephropathy (IgAN)

• Swelling in arms, legs, or feet (17%)
• High blood pressure (12%)
• Muscle spasms (12%)
• Acne (11%)
• Headache (10%)
• Upper respiratory tract infection (8%)
• Facial swelling (8%)
• Weight gain (7%)
• Indigestion (7%)

• Changes in stress hormone levels in the body
• Higher risk of infections
• Worsening of certain medical conditions