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Dorzolamide vs. Cosopt

Dorzolamide is an eye drop medication used to treat high pressure in the eye in people with glaucoma or ocular hypertension. The dosage is 1 drop applied directly into the affected eye(s) three times per day. It's available as a generic only as the brand-name medication Trusopt has been discontinued. Dorzolamide is a sulfa medication, so it might not be the best choice if you have a serious sulfa allergy. Side effects include burning or stinging in the eye and a bitter taste in the mouth.

Treatment of high pressure in the eye in people with:

• Ocular hypertension
• Open-angle glaucoma

• Burning or stinging in the eye (33%)
• Bitter taste (25%)
• Bacterial eye infection (10-15%)
• Allergic reaction in the eye (10%)

• Severe allergic reactions
• Risk for eye infection (from contamination)
• Risk for swelling of the cornea

Cosopt is a combination ophthalmic drop (eye drop) medication that contains dorzolamide (a carbonic anhydrase inhibitor) and timolol (a beta blocker). It's used to lower eye pressure for certain people with glaucoma or high eye pressure. Typically, one drop of Cosopt (dorzolamide / timolol) is placed into the affected eye(s) twice a day. Common side effects of this medication include changes in taste, blurry vision, and itchy eyes. Cosopt (dorzolamide / timolol) is available as both brand name and generic medications. It comes in a multi-dose bottle, as well as single-use, preservative-free vials.

• To lower eye pressure in people with open-angle glaucoma or high eye pressure

• Changes in taste (up to 30%)
• Eye burning or stinging (up to 30%)
• Blurry vision (5-15%)
• Itchy eye (5-15%)
• Corneal inflammation (5-15%)
• Eye redness (5-15%)

• Risk of difficulty breathing
• Heart failure
• Severe allergic and skin reactions
• Hiding symptoms of low blood sugar
• Hiding symptoms of overactive thyroid
• Greater risk during surgery
• Cornea swelling
• Eye inflammation and infection
• Risk of muscle weakness