Bylvay vs. Livmarli for Inherited Metabolic Diseases: Important Differences and Potential Risks.

Bylvay

(odevixibat)

Livmarli

(maralixibat)

Summary for Bylvay

Prescription only

Bylvay (odevixibat) is a newly approved medication for the treatment of itching in children with a genetic liver condition called progressive familial intrahepatic cholestasis (PFIC). It's taken once per day by mouth, and is available in both capsules and pellets that can be mixed with soft foods.

Indications for Bylvay

Itching in children 3 months and older with progressive familial intrahepatic cholestasis (PFIC)

Pros and Cons for Bylvay

Pros

Can be used in children as young as 3 months old
Taken once per day
Contents from capsules and pellets can be sprinkled onto food for those who have trouble swallowing
Dosing can be individualized based on weight

Cons

Brand name only, which can be expensive
Needs to be taken with food
Can cause liver problems, diarrhea, and poor absorption of vitamins A, D, E, and K

Common Side Effects for Bylvay

Diarrhea (31%)
Vomiting (17%)
Liver damage (17%)
Stomach pain (14%)

Warnings for Bylvay

Worsening liver problems and liver failure
Diarrhea
Low levels of vitamins A, D, E, and K

Summary for Livmarli

Prescription only

Livmarli (maralixibat) is FDA approved to help with itching caused by liver problems (cholestatic pruritis) from certain genetic conditions. It's for adults and children with Alagille syndrome (ALGS). This medication is also for people 1 year and older with progressive familial intrahepatic cholestasis (PFIC). It works as an ileal bile acid transporter (IBAT) inhibitor. Livmarli (maralixibat) comes as a tablet and a liquid. You take each dose by mouth on an empty stomach. Common side effects include diarrhea and stomach pain.

Indications for Livmarli

Itching caused by liver problems (cholestatic pruritis) from:
- Alagille syndrome (ALGS) in people 3 months of age and older
- Progressive familial intrahepatic cholestasis (PFIC) in people 1 year of age and older

Pros and Cons for Livmarli

Pros

Works well to help improve itchiness from ALGS and PFIC
Approved for both adults and children with ALGS or PFIC
Available as a tablet and a grape-flavored liquid

Cons

Need to take 30 minutes before a meal
Might take several weeks to start working
Can cause stomach upset and poor absorption of certain vitamins (vitamins A, D, E, and K)

Common Side Effects for Livmarli

ALGS:

Diarrhea (56%)
Stomach pain (54%)
Vomiting (41%)
Low vitamin A, D, E, and K levels (26%)
Higher liver enzyme levels (19%)

PFIC:

Diarrhea (57%)
Stomach pain (28%)
Higher liver enzyme levels (17%)

Warnings for Livmarli

Liver damage
Stomach upset
Low vitamin A, D, E, and K
Risk of propylene glycol toxicity in young children

Prices with our coupons for Bylvay vs. Livmarli

Bylvay60 capsules / 1200mcg

$91,958.89$108,887.75

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Livmarli60 tablets / 20mg of

$262,183.28-

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Bylvay vs. Livmarli

Bylvay

Livmarli

Summary for Bylvay

Indications for Bylvay

Pros and Cons for Bylvay

Pros

Cons

Common Side Effects for Bylvay

Warnings for Bylvay

Summary for Livmarli

Indications for Livmarli

Pros and Cons for Livmarli

Pros

Cons

Common Side Effects for Livmarli

Warnings for Livmarli

Prices with our coupons for Bylvay vs. Livmarli

Browse medications by letter

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Bylvay

Livmarli

Summary for Bylvay

Indications for Bylvay

Pros and Cons for Bylvay

Pros

Cons

Common Side Effects for Bylvay

Warnings for Bylvay

Summary for Livmarli

Indications for Livmarli

Pros and Cons for Livmarli

Pros

Cons

Common Side Effects for Livmarli

Warnings for Livmarli