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Clobazam Coupon - Clobazam 10mg tablet

clobazam

Generic Onfi
Used for Lennox-Gastaut Syndrome
Used for Lennox-Gastaut Syndrome

Clobazam (Onfi) is used to treat seizures in people ages 2 years and older with Lennox-Gastaut syndrome (LGS). The medication belongs to the drug class known as benzodiazepines, which work by slowing down activity in the brain. Clobazam (Onfi) is available as a lower-cost generic tablet and oral liquid suspension, and it's taken by mouth twice per day. Possible side effects include sleepiness, fever, and vomiting.

Reviewed by:
reviewer
Robert Chad Hakim, PharmD, BCCCP
reviewer
Kristianne Hannemann, PharmD
Last reviewed on November 15, 2023
BasicsWarningsSide effectsPros & consPharmacist tipsFAQsDosageInteractionsCostAlternativesLatest newsImagesReferencesPricesMedicare
Clobazam (Onfi) is a controlled substance, which means that it's more likely to be misused or cause dependence. There are federal and state laws that limit the amount of medication that can be prescribed or dispensed within a certain period of time.
basics-icon

What is Clobazam (Onfi)?

What is Clobazam (Onfi) used for?

  • Treatment of seizures from Lennox-Gastaut syndrome in people ages 2 years and older (as an add-on to other anti-seizure medications)

How Clobazam (Onfi) works

Clobazam (Onfi) is a benzodiazepine that's used only as an anti-seizure medication. It's thought to work by raising the activity of a chemical in the brain called gamma-aminobutyric acid (GABA). This helps to calm down brain activity and lower the risk of seizures.

Are you looking for information on Sympazan (clobazam) oral film or clonazepam (Klonopin) instead?

Drug Facts

Common BrandsOnfi
Drug ClassBenzodiazepine
Controlled Substance ClassificationSchedule IV
Generic StatusLower-cost generic available
AvailabilityPrescription only
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What are the risks and warnings for Clobazam (Onfi)?

Clobazam (Onfi) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

risk-warning

Serious risks when used with opioids

Taking clobazam (Onfi) with opioid medications can cause severe sleepiness, tiredness, dangerously slow breathing, coma, or even death. These side effects can happen to anyone who's taking both medications. Clobazam (Onfi) and an opioid should be used together only if they're clearly needed and the benefits are greater than the risks. Your provider will prescribe the lowest dose of your medications for the shortest period of time possible in this case.

Tell your provider about all your medications before and during treatment with clobazam (Onfi). Get medical help right away if you or your loved ones notice you're breathing a lot slower or having trouble waking up easily.

risk-warning

Potential for misuse, addiction, and withdrawal

  • Risk factors: Personal or family history of alcohol or substance use disorder | Personal or family history of mental health problems

    Clobazam (Onfi) is a controlled substance because it has a risk for misuse, which can lead to addiction. Misusing clobazam (Onfi) can raise the risk for side effects, such as memory and coordination problems, confusion, and muscle pain. It can also raise your risk for serious and possibly life-threatening slowed breathing and coma.

    Clobazam (Onfi) also has a risk for dependence (when your body needs the medication to function normally). Stopping the medication too suddenly can lead to withdrawal symptoms, such as nausea, tremors, sweating, muscle pain, and life-threatening seizures, panic attacks, and psychosis.

    Take clobazam (Onfi) exactly as prescribed. Don't change the dose or how often you take it without talking to your healthcare provider first. Your provider will prescribe the lowest amount of medication that's necessary to manage your seizures for the shortest period of time possible.

    risk-warning

    Extreme sleepiness or tiredness, leading to trouble with concentration

    • Risk factors: Taking higher doses of clobazam (Onfi) | Drinking alcohol | Taking other medications that can cause sleepiness

      Clobazam (Onfi) can cause extreme sleepiness, which can lower your ability to think, react, and focus. You can feel sleepier than usual within the first month of treatment, and it might lessen as you continue taking the medication. Your risk for these side effects is higher if you're taking other medications that can make you tired (e.g., other benzodiazepines, muscle relaxants). Make sure you know how clobazam (Onfi) affects you before driving a car or doing activities that require your concentration. Talk to your provider right away if these side effects affect your daily life while you're taking clobazam (Onfi).

      risk-warning

      Serious skin reactions

      Clobazam (Onfi) can cause serious and life-threatening skin reactions, such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Watch for unusual skin reactions during treatment, especially during the first 2 months of starting, or restarting, clobazam (Onfi). Stop using the medication and get medical attention as soon as possible if you notice a sore throat, fever, fatigue, rash, painful blisters, skin reddening, skin peeling, swelling in your face, or trouble breathing.

      risk-warning

      Suicidal thoughts or behavior

      • Risk factors: Taking other anti-seizure medications

        Clobazam (Onfi) raises your risk of having thoughts of suicide or harming yourself. This risk can appear as early as 1 week after you start taking clobazam (Onfi) and can continue throughout treatment. Get medical help right away if you or anyone around you notices that you have suicidal thoughts or unusual behavior, like anxiety, panic attacks, trouble sleeping, feeling angry or irritated, or restlessness, while you're taking clobazam (Onfi).

        risk-warning

        Side effects in newborn babies when used during pregnancy

        Side effects like weakness, slowed breathing, and withdrawal symptoms (e.g., irritability, restlessness, trouble feeding) can happen in newborn babies if mothers take clobazam (Onfi) during late pregnancy. Talk to your provider about the risks and benefits of using clobazam (Onfi) while you're pregnant. It's encouraged that you enroll in the North American Antiepileptic Drug (NAAED) Pregnancy Registry if you're currently pregnant and taking clobazam (Onfi). This registry monitors the safety of anti-seizure medications during pregnancy and helps researchers learn more about the risks.

        More on Clobazam (Onfi) warnings

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        Written by Eric Patterson, LPC
        basics-icon

        What are the side effects of Clobazam (Onfi)?

        The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

        Common Side Effects

        Other Side Effects

        • Cough
        • Slurred speech
        • Trouble swallowing
        • Constipation
        • Pain with urination
        • Changes in appetite
        • Trouble sleeping
        • Problems with coordination

        Serious Side Effects

        Contact your healthcare provider immediately if you experience any of the following.
        • Serious allergic and skin reactions: fever, sore throat, fatigue, rash, hives, painful blisters, skin reddening, skin peeling, swollen lymph nodes
        • Severe sleepiness and dizziness
        • Suicidal behavior or thoughts of self-harm

        Source: DailyMed

        More on Clobazam (Onfi) side effects

        benzodiazepine: side effects benzodiazepine

        8 Benzodiazepine Side Effects You Should Know About

        Written by Amy B. Gragnolati, PharmD, BCPS

        The following side effects have also been reported

        Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

        Check with your doctor immediately if any of the following side effects occur:

        More common

        Difficulty with swallowing

        fever

        shakiness and unsteady walk

        unsteadiness, trembling, or other problems with muscle control or coordination

        Less common

        Change in speech pattern

        restlessness

        slurred speech

        trouble sitting still

        trouble speaking

        Incidence not known

        Agitation

        black, tarry stools

        bleeding gums

        blistering, peeling, or loosening of the skin

        blood in the urine or stools

        chest pain

        chills

        confusion as to time, place, or person

        cough

        diarrhea

        difficult or trouble breathing

        holding false beliefs that cannot be changed by fact

        irregular, fast or slow, or shallow breathing

        itching, rash, hives, or welts

        joint or muscle pain

        lack of feeling or emotion

        painful or difficult urination

        pale or blue lips, fingernails, or skin

        pinpoint red spots on the skin

        red skin lesions, often with a purple center

        red, irritated eyes

        seeing, hearing, or feeling things that are not there

        sore throat

        sores, ulcers, or white spots in the mouth or on the lips

        swollen glands

        unusual bleeding or bruising

        unusual excitement, nervousness, or restlessness

        unusual tiredness or weakness

        Get emergency help immediately if any of the following symptoms of overdose occur:

        Symptoms of overdose

        Blurred vision

        change or loss of consciousness

        confusion

        dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

        sweating

        unusual drowsiness, dullness, or feeling of sluggishness

        Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

        More common

        Aggressive

        body aches or pain

        decreased appetite

        difficulty having a bowel movement

        drooling

        ear congestion

        irritability

        loss of voice

        runny or stuffy nose

        sneezing

        vomiting

        Less common

        Bladder pain

        cloudy urine

        cough with mucus

        frequent urge to urinate

        increased appetite

        lower back or side pain

        Incidence not known

        Double vision

        full or bloated feeling

        headache

        muscle spasms

        pressure in the stomach

        red skin

        swelling of the stomach area

        Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

        Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

        pros-and-cons

        Pros and cons of Clobazam (Onfi)

        thumbs-up

        Pros

        Works well to control the number of seizures you have if you have Lennox–Gastaut syndrome

        Can give to children 2 years of age and older

        Comes as a liquid, which is helpful if you have trouble swallowing pills

        Doesn't have many drug interactions compared to other anti-seizure medications

        thumbs-down

        Cons

        Only approved for seizures related to Lennox-Gastaut syndrome

        Need to take with other anti-seizure medications

        Might lead to tolerance (doesn't work as well after you've taken it for a while)

        Might have more frequent seizures if you suddenly stop taking the medication

        pharmacist-tips

        Pharmacist tips for Clobazam (Onfi)

        pharmacist

        • You can take clobazam (Onfi) with or without food. If the medication upsets your stomach, try taking it with food to help.

          • Clobazam (Onfi) can make you sleepy and dizzy. Avoid drinking alcohol, driving, or doing anything that requires concentration until you know how this medication affects you.

            • Clobazam (Onfi) can raise the risk of suicidal thoughts. Contact your provider right away if you or your loved ones notice any changes in your behavior or mood while you're taking this medication.

              • Don't change your dose or suddenly stop taking clobazam (Onfi) without talking to your provider first. Otherwise, you might have withdrawal symptoms, like nausea, tremors, sweating, muscle pain, more seizures, or panic attacks. Speak with your provider if you're interested in stopping the medication; follow the instructions to lower your dose slowly over a period of time to safely stop the medication.

                • Make sure to tell your provider and pharmacist about all of the medications you're taking with clobazam (Onfi). Clobazam (Onfi) can interact with some commonly prescribed medications, such as omeprazole (Prilosec), and fluconazole (Diflucan). Your providers can check that your medications are safe to take together.

                  • Clobazam (Onfi) can make hormonal birth control work less well, which can lead to unplanned pregnancies. Talk to your provider about which methods of birth control you should use instead and whether you need to use a back-up method of protection while you're taking clobazam (Onfi).

                    • Contact your provider right away if you become pregnant to discuss the risks and benefits of continuing clobazam (Onfi). This medication can raise the risk of serious side effects, like slowed breathing and withdrawal, in newborns when it's taken during late pregnancy.

                      More tips for clobazam (Onfi) oral liquid suspension:

                      • Read the instructions for use on how to prepare a dose of the clobazam (Onfi) oral liquid suspension. Ask your pharmacist or provider if you have any questions.

                        • Store the clobazam (Onfi) oral liquid suspension at room temperature in the original bottle it came in from the pharmacy.

                          • Shake the bottle well before you measure the dose. Make sure to use an oral syringe to measure out your clobazam (Onfi) liquid dose. Don't use household spoons because they aren't accurate and might cause you to take the wrong dose.

                            • Clean the oral syringe after each time you take the medication. Remove the plunger from the barrel, wash both parts with soap and water, and let it to air dry. Don't put the oral syringe in the dishwasher.

                              • Once you open a new bottle, the medication is good for 90 days (3 months). Write down the 90-day expiration date after you open the bottle to avoid accidentally using expired medication. After 90 days, throw the bottle away, even if there's medication left over. Then, ask your pharmacist or provider for a refill.

                                faqs

                                Frequently asked questions about Clobazam (Onfi)

                                Is clobazam (Onfi) a controlled substance?
                                Yes, clobazam (Onfi) is a schedule IV controlled substance. This is because it has a risk for misuse, which can lead to addiction. Misuse is when a medication is used for non-medical reasons for its physical or emotional effects (e.g., a "high" feeling). Misusing clobazam (Onfi) can lead to serious and potentially life-threatening side effects like seizures and trouble breathing. Clobazam (Onfi) also has a risk for dependence (when you rely on a medication to function normally). With dependence, you might have withdrawal symptoms if you suddenly stop taking the medication. To help lower the risks for misuse and dependence, only take clobazam (Onfi) exactly as instructed by your provider.
                                Is clobazam (Onfi) a narcotic?
                                No, clobazam (Onfi) isn't a narcotic. Narcotics are another name for opioid medications. Clobazam (Onfi) isn't an opioid and so it isn't a narcotic. Instead, clobazam (Onfi) is considered a benzodiazepine.
                                How long does clobazam (Onfi) take to work?
                                There isn't a clear time frame for when exactly clobazam (Onfi) will start to work. It'll probably depend on several factors, like your dose, how bad your seizures are, and what other seizure medications you're taking. It takes about a week for clobazam (Onfi) to reach a steady level in your body. In general, reaching the dose that's right for you can take time — you typically start the medication at a low dose and your dose gets raised no sooner than once per week. Studies generally show that it can take up to 3 months of treatment with clobazam (Onfi) to see improvements in seizures. Your provider will regularly follow up with you to discuss how well clobazam (Onfi) is working for you and adjust your dose as needed.
                                Can clobazam (Onfi) be crushed?
                                Yes. If you're having trouble swallowing the clobazam (Onfi) tablets, you can crush the tablets and mix into applesauce. You can also break the tablets in half along the score line (the dented line in the middle of the tablet). In addition, you can ask your provider about switching you to the clobazam (Onfi) liquid suspension.
                                Does clobazam (Onfi) make you sleepy?
                                Yes, sleepiness is the most common side effect of clobazam (Onfi). In studies, sleepiness was reported in up to 26% of people who took clobazam (Onfi). Before driving or performing activities that require you to be alert, wait and see how this medication affects you. Talk to your provider if clobazam (Onfi) is making you too sleepy throughout the day and is affecting your ability to do daily activities. You might need your dose adjusted or you might need to switch to a different medication.
                                Does clobazam (Onfi) cause weight gain?
                                Studies suggest that clobazam (Onfi) doesn't affect weight very much. But keep in mind that clobazam (Onfi) is typically used with other anti-seizure medications, some of which might cause weight gain. Keep track of your weight, eat nutritious meals, and regularly exercise while you're taking clobazam (Onfi) to keep your risk low. Tell your provider if you or your child has gained an unusual amount of weight after starting this medication.
                                Does clobazam (Onfi) help with anxiety?
                                Clobazam (Onfi) is a benzodiazepine or "benzo", which is a drug class that's known to work well for treating anxiety. But unlike most benzos, clobazam (Onfi) isn't FDA-approved to treat anxiety; it's only approved for seizures in people with Lennox-Gastaut syndrome. Some research looking specifically at clobazam (Onfi) suggests that it can help with anxiety, both in people with and without seizures. Talk to your provider to see whether clobazam (Onfi) is right for you if you have both anxiety and seizure problems.
                                Is clobazam (Onfi) and clonazepam the same?
                                No, clobazam (Onfi) and clonazepam (Klonopin) are both benzodiazepines, but they're two completely different medications. The biggest difference is what they're used for. They're both approved for treating seizures from Lennox-Gastaut syndrome, but clonazepam (Klonopin) is also used for treating other types of seizures as well as panic disorder.
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                                dosage

                                Clobazam (Onfi) dosage forms

                                The average cost for 60 tablets of 10mg of Clobazam (Onfi) is $29.69 with a free GoodRx coupon. This is 96.16% off the average retail price of $772.29.
                                bottle of oral suspension
                                Bottle of oral suspension
                                DosageQuantityPrice as low asPrice per unit
                                120ml of 2.5mg/ml1 bottle$31.91$31.91
                                tablet
                                Tablet
                                DosageQuantityPrice as low asPrice per unit
                                10mg60 tablets$29.69$0.49
                                20mg60 tablets$36.59$0.61

                                Typical dosing for Clobazam (Onfi)

                                Clobazam (Onfi) is available as a tablet and a oral suspension (liquid) with similar dosing.

                                Your dose is based on your body weight. Your dose might differ if you're of older age, if you have liver problems, or if you have certain genetics that affect how well your body breaks down the medication.

                                • Weight greater than 66 lbs: The typical starting dose is 5 mg by mouth twice a day. The maximum dose is 20 mg twice a day (total 40 mg per day).

                                • Weight 66 lbs or less: The typical starting dose is 5 mg by mouth once a day. The maximum dose is 10 mg twice a day (total 20 mg per day).

                                Your provider will change your dose during treatment based on how well clobazam (Onfi) is helping your seizures and whether you're having side effects.

                                interactions

                                Interactions between Clobazam (Onfi) and other drugs

                                Clobazam (Onfi) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Clobazam (Onfi). Please note that only the generic name of each medication is listed below.

                                More on Clobazam (Onfi) interactions

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                                Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                                Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                                Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                                drug-cost

                                How much does Clobazam (Onfi) cost?

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                                Onfi (brand)
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                                alternatives

                                What are alternatives to Clobazam (Onfi)?

                                There are a number of medications that your doctor can prescribe in place of Clobazam (Onfi). Compare a few possible alternatives below.
                                Clobazam (Onfi)
                                Used for:

                                • Treatment of seizures from Lennox-Gastaut syndrome in people ages 2 years and older (as an add-on to other anti-seizure medications)

                                $29.69 Lowest GoodRx priceView Prices
                                Rufinamide (Banzel)
                                Used for:
                                $74.36 Lowest GoodRx priceView Prices
                                Felbamate (Felbatol)
                                Used for:

                                • Partial seizures in adults with epilepsy

                                • Seizures linked to Lennox-Gastaut syndrome (LGS) in children - add-on treatment

                                $115.34 Lowest GoodRx priceView Prices
                                images

                                Clobazam (Onfi) images

                                White Oval U 1 - Clobazam 10mg Tablet
                                This medicine is White, Oval Tablet Imprinted With "U 1".White Oval U 1 - Clobazam 10mg Tablet
                                White Oval C 9 And H - Clobazam 10mg Tablet
                                This medicine is White, Oval Tablet Imprinted With "C 9" And "H".White Oval C 9 And H - Clobazam 10mg Tablet
                                White Oval 1 0 - Clobazam 10mg Tablet
                                This medicine is White, Oval Tablet Imprinted With "1 0".White Oval 1 0 - Clobazam 10mg Tablet

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                                References

                                Best studies we found

                                Buraniqi, E., et al. (2022). Impact of antiseizure medications on appetite and weight in children. Pediatric Drugs.

                                Centers for Disease Control and Prevention. (2020). Spoons are for soup, milliliters are for medicine.

                                Department of Justice/Drug Enforcement Administration. (2020). Narcotics.

                                View All References (8)

                                Gauthier, A. C., et al. (2015). Clobazam: A safe, efficacious, and newly rediscovered therapeutic for epilepsy. Central Nervous System Neuroscience & Therapeutics.

                                Hamed, S, A. (2014). Antiepileptic drugs influences on body weight in people with epilepsy. Expert Review of Clinical Pharmacology.

                                Huddart, R., et al. (2018). PharmGKB summary: clobazam pathway, pharmacokinetics. Pharmacogenetics and Genomics.

                                Humayun, M. J., et al. (2023). Clobazam. StatPearls.

                                Jewett, B. E., et al. (2023). Physiology, GABA. StatPearls.

                                Lundbeck Pharmaceuticals LLC. (2016). Instructions for use: Onfi® (ON-fee) (clobazam) oral suspension, CIV.  

                                Lundbeck Pharmaceuticals LLC. (2024). Onfi- clobazam tablet; clobazam suspension [package insert]. DailyMed.

                                National Institute of Neurological Disorders and Stroke. (2023). Lennox-Gastaut syndrome.

                                GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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