TRPV1 agonists are used to treat certain types of nerve pain, such as postherpetic neuralgia, and diabetic peripheral neuropathy. They also have other uses, such as relieving minor muscle and joint aches. TRPV1 agonists work by activating the transient receptor potential vanilloid 1 (TRPV1) receptor, which helps to reduce pain signals in your nervous system. These medications are available in different forms, including topical patches and topical creams. An example of a topical patch is Qutenza (capsaicin). You can choose the form that best fits your needs.