NK1 / serotonin antagonist combinations are used to treat nausea and vomiting caused by chemotherapy. These medications work by blocking the action of two key pathways involved in nausea and vomiting. The NK1 receptor antagonist blocks neurokinin-1 receptors, while the 5-HT3 receptor antagonist blocks serotonin receptors. These combinations are available in different forms, including oral capsules and injectable solutions. Examples include netupitant / palonosetron (Akynzeo) and fosnetupitant / palonosetron (Akynzeo injection).
