Estrogen / progestin / folate combinations are used to prevent pregnancy, treat acne, and manage premenstrual dysphoric disorder (PMDD). They work by combining hormones that prevent ovulation, regulate your menstrual cycle, and reduce symptoms of acne and PMDD. They also include folate, a type of B vitamin, which can help prevent certain types of anemia. These medications are available as oral tablets. Examples include drospirenone / ethinyl estradiol / levomefolate (Beyaz, Safyral). You can discuss with your healthcare team which option might be right for you.