Cefprozil is an antibiotic that can be taken by adults or children to treat many types of bacterial infections, such as those that affect the throat and ears. This medication is taken by mouth, usually once or twice daily for about 10 days. It's available as a tablet and a liquid suspension. People typically don't experience many side effects with cefprozil. But the most common ones include nausea and diarrhea.
Lung infections related to long-term bronchitis
Skin infections
Cefprozil is a cephalosporin antibiotic. It kills bacteria by preventing them from making an additional covering around themselves for protection.
Source:Â DailyMed
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Less common
Black, tarry stools
cough or hoarseness
fever or chills
lower back or side pain
painful or difficult urination
shortness of breath
sore throat sores, ulcers, or white spots on the lips or in the mouth
swollen glands
unusual bleeding or bruising
unusual tiredness or weakness
Rare
Abdominal or stomach cramps, pain, or tenderness
bleeding gums
blistering, peeling, or loosening of the skin
blood in the urine or stools
clay-colored stools
dark urine
diarrhea, watery and severe, which may also be bloody
difficulty with swallowing
dizziness
fast heartbeat
feeling of discomfort
headache
increased thirst
inflammation of the joints
joint or muscle pain
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
loss of appetite
muscle aches
nausea or vomiting
pinpoint red spots on the skin
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
rash
red skin lesions, often with a purple center
red, irritated eyes
shortness of breath
swollen lymph glands
tightness in the chest
unpleasant breath odor
unusual weight loss
vomiting of blood
watery or bloody diarrhea
yellow eyes or skin
Incidence not known
Back, leg, or stomach pains
bleeding gums
bloody or cloudy urine
bloody, black, or tarry stools
decrease in urine output or decrease in urine-concentrating ability
difficulty with breathing
fever with or without chills
general body swelling
general feeling of tiredness or weakness
high fever
nosebleeds
pale skin
sudden decrease in the amount of urine
swollen or painful glands
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
Itching or pain of the vagina or genital area
pain during sexual intercourse
thick, white vaginal discharge with no odor or with a mild odor
Rare
Confusion
hives or welts
nervousness
redness of the skin
restlessness
sleepiness or unusual drowsiness
trouble sitting still
trouble with sleeping
unable to sleep
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Treats many types of bacterial infections and generally has few side effects
Can be taken with or without food
Available as a liquid suspension for people who have trouble swallowing tablets
Available as a lower-cost generic
Might not be able to take this medication if you've had a severe allergy to penicillins or other cephalosporin antibiotics
Might not be a good choice for people with kidney problems
The suspension contains phenylalanine, which can be a problem for people with PKU
Take cefprozil exactly as prescribed. Make sure to finish your treatment course, even if you start feeling better. Stopping the medication earlier than prescribed can make your infection come back and become harder to treat.
Take cefprozil with or without food. If it's upsetting your stomach, taking it with food might help.
Cefprozil can cause diarrhea. Typically, the diarrhea is mild and should go away when you stop taking cefprozil. But if you start having watery or bloody diarrhea, fever, fatigue, or stomach cramps anytime during treatment or after stopping cefprozil, call your provider right away. These can be signs of a kind of infectious diarrhea that can be serious and needs to be treated right away.
Contact your provider or get medical help as soon as possible if you get a rash, itchy skin, trouble breathing, or swelling in your face or mouth. These could be signs of a severe allergic reaction.
Tips for cefprozil oral suspension (liquid)
The suspension comes in two strengths, 125 mg/5 mL and 250 mg/5 mL. Make sure you know which strength you have to avoid accidentally taking the wrong dose. Ask your pharmacist for help if you're not sure.
Before each dose, shake the bottle well to make sure the medication hasn't settled at the bottom.
Make sure to only use a medication dose cup or oral syringe from the pharmacy to measure out your dose. Don't use household spoons because they aren't accurate and might cause you to take the wrong dose.
Store the cefprozil liquid suspension in the refrigerator for up to 2 weeks. After 2 weeks, throw away the bottle, even if there's still some medication left.
Cefprozil can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Risk factors: Allergy to penicillin or other cephalosporin antibiotics
Severe allergic reactions to cefprozil are possible, including life-threatening reactions like facial swelling, shock, and anaphylaxis (closing of the throat). Let your provider know if you're allergic to any antibiotics. If you've had a reaction to penicillin antibiotics in the past, you might not be able to take cefprozil. If you notice hives, rash, red skin, swelling of the lips or tongue, or difficulty breathing after using cefprozil, get medical attention right away.
Taking cefprozil, as well as other antibiotics, can raise your risk of getting diarrhea caused by a bacteria called Clostridioides difficile (C. diff), which can be life-threatening. C.diff is a bacteria that's naturally found in the gut. Typically, it doesn't cause any problems because other gut bacteria keep its growth in check. But antibiotics can kill off some gut bacteria and cause C.diff to grow out of control.
It's important to recognize the difference between diarrhea as a side effect of cefprozil and this type of infectious diarrhea. C. diff-related diarrhea can cause rapid heart rate, foul-smelling diarrhea, fever, nausea, frequent bowel movements (even up to 15 times per day) and is an emergency. If you experience any of these symptoms, get medical attention right away so you can be tested for C. diff infection and receive treatment. Sometimes, C. diff-related diarrhea can occur 2 months after your antibiotic treatment.
Take cefprozil exactly as prescribed. Stopping cefprozil too early or taking the antibiotic for illnesses other than what your provider has prescribed can raise your risk for developing infections caused by drug-resistant bacteria. This raises your risk for severe and life-threatening infections that might be difficult to treat.
The cefprozil suspension contains phenylalanine, an ingredient that can cause serious health problems if you have phenylketonuria (PKU). Talk to a healthcare provider for alternative medications that are safer for you.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Severe allergy to cephalosporin antibiotics
Lung infections related to long-term bronchitis
Skin infections
Lung infections related to long-term bronchitis
Skin infections
Ear infections - for children only
Lung infection related to long-term bronchitis
Skin infection
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DeBoer, D. L., et al. (2022). Acute sinusitis. StatPearls.
Lupin Pharmaceuticals, Inc. (2023). CEFPROZIL powder, for suspension. DailyMed.
Lupin Pharmaceuticals, Inc. (2023). CEFPROZIL tablet. DailyMed.
Maguire, M., et al. (2020). Beta-lactam antibiotic test doses in the emergency department. The World Allergy Organization Journal.
MedlinePlus. (n.d.). Chronic bronchitis.
National Human Genome Research Institute. (2014). About phenylketonuria.
Drugs and Lactation Database (LactMed). (2018). Cefprozil. National Institute of Child Health and Human Development.
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