Auvelity

Antidepressant medications, like Auvelity (dextromethorphan / bupropion), can raise the risk of having suicidal thoughts or behavior. The risk is higher for people under the age of 24. Watch for new or worsening depression and suicidal thoughts or behavior. Pay extra attention to your mood, especially during the first few months of treatment or if there's a dose change to your medication. Let your healthcare provider know right away if you notice any unusual changes in your mood or behavior, or if you have thoughts of wanting to harm yourself, while taking this medication.

Bupropion, one of the medications in Auvelity (dextromethorphan / bupropion), can raise your risk of seizures. Seizures are unlikely if you take Auvelity (dextromethorphan / bupropion) as directed by your provider. But your risk for seizures goes up if you take more than recommended. Don't take Auvelity (dextromethorphan / bupropion) if you have a history of seizures or conditions that raise your risk of seizures (e.g., head trauma; eating disorders; stroke; recently stopping alcohol use; or take medications like benzodiazepines, barbituates, or seizure medications).

Bupropion can raise your blood pressure. Your risk is higher if you're also taking medications that can raise blood pressure, like nicotine replacement products and monoamine oxidase inhibitors (MAOIs), such as selegiline (Zelapar) and phenelzine (Nardil). That's why it's not recommended to take MAOIs within 14 days of Auvelity (dextromethorphan / bupropion). Check your blood pressure often, and let your healthcare provider know if your blood pressure rises.

Antidepressants, like Auvelity (dextromethorphan / bupropion), can trigger mania or hypomania. This is more likely to happen if you or someone in your family have bipolar disorder. Talk to your healthcare provider right away if you notice unusual changes in your behavior or thoughts. Get medical help right away if you feel extreme happiness, jumpy, irritable, or have racing thoughts.

Serotonin syndrome is a rare, but potentially life-threatening condition where there's too much serotonin active in the brain. Serotonin is one of the chemicals in your brain responsible for your mood. Your risk goes up if you use Auvelity (dextromethorphan / bupropion) with other medications that affect serotonin levels (other antidepressants, certain antinausea medications, triptans, St. John's wort). Symptoms of too much serotonin include fast heart rate, sweating, muscle stiffness or spasms, fever, and confusion. Tell your healthcare provider or get medical help right away if you experience any of these symptoms.