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Arthrotec

Arthrotec Side Effects

Robert Chad Hakim, PharmD, BCCCPKristianne Hannemann, PharmD
Reviewed by Robert Chad Hakim, PharmD, BCCCP, Kristianne Hannemann, PharmD
Last reviewed on July 12, 2024

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Stomach pain (21%)
  • Diarrhea (19%)
  • Upset stomach or indigestion (14%)
  • Nausea (11%)
  • Gas (9%)

Less Common Side Effects

  • Vomiting
  • Constipation
  • Dry mouth
  • Headache
  • Dizziness
  • Fatigue
  • Vaginal bleeding
  • Menstrual cramps

Arthrotec serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Heart attack: dizziness, tiredness, cold sweat, trouble breathing, chest pain or tightness, anxiety
  • Stroke: tiredness, lightheadedness, blurred vision, difficulty speaking, difficulty walking, weakness on one side of the body
  • Stomach bleeds: blood in your vomit, stool that looks like black coffee grounds, pain in your stomach that doesn't go away
  • Heart failure: trouble breathing, tiredness, swelling in your body, sudden weight gain
  • Liver damage: fever, chills, fatigue, nausea, vomiting, yellowing of the skin or whites of the eyes, clay-colored stool, dark urine
  • Kidney damage and high potassium: nausea, muscle weakness, tingling sensations in your muscles, changes in how much you urinate
  • Severe asthma attack: chest pain, cough, difficulty breathing, wheezing
  • Serious allergic or skin reaction: fever, rash, body aches, cough, swelling of the face, peeling skin, painful blisters all over your body

Source: DailyMed

The following Arthrotec side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Stomach pain

Less common

Black, tarry stools

bladder pain

bloody or cloudy urine

burning feeling in the chest or stomach

burning while urinating

chest pain, discomfort, or tightness

chills

cough

deep or fast breathing with dizziness

difficult, burning, or painful urination

difficulty swallowing

dizziness

double vision

feeling of constant movement of self or surroundings

fever

frequent urge to urinate

heartburn

increased sensitivity of the skin to sunlight

increased volume of pale, dilute urine

indigestion

itching, skin rash

lightheadedness

longer or heavier menstrual periods

lower back or side pain

nosebleed

numbness of the feet, hands, and around the mouth

pain or burning in the throat

pain with swallowing

redness or other discoloration of the skin

seeing double

sensation of spinning

severe sunburn

sores, ulcers, or white spots on the lips or in the mouth

sore throat

stomach upset or tenderness

swollen glands

unusual bleeding or bruising

unusual tiredness or weakness

vaginal bleeding

vomiting with or without blood

Incidence not known

Ankle, knee, or great toe joint pain

anxiety

black, tarry stools

bleeding gums

blindness

blistering, peeling, or loosening of the skin

bloating or swelling of the face, arms, hands, lower legs, or feet

bluish color of the skin

blurred vision

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

burning, dry, or itching eyes

cloudy or dark urine

decreased frequency or amount of urine

decreased vision

diarrhea

difficulty in speaking

dilated neck veins

discharge, excessive tearing

dizziness, fainting, or lightheadedness when getting up suddenly from a lying or sitting position

drowsiness

excessive muscle tone

extreme tiredness or weakness

eye pain

fainting

fast, irregular, pounding, or racing heartbeat or pulse

general feeling of illness

headache, severe and throbbing

hoarseness

inability to move the arms, legs, or facial muscles

inability to speak

increased sensitivity to pain or touch

increased thirst

irregular, fast or slow, or shallow breathing

joint pain, stiffness, or swelling

large, hive-like swelling on the pain, face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals

light-colored stools

lightheadedness

loss of appetite

loss of consciousness

muscle stiffness, tension, or tightness

nausea

nervousness

night blindness

pain or discomfort in the arms, jaw, back, or neck

pains in the stomach, side, or abdomen, possibly radiating to the back

pain, warmth, or burning in the fingers, toes, and legs

pale or blue lips, fingernails, or skin pale skin

pinpoint red spots on the skin

pounding in the ears

problems with vision or hearing

rapid weight gain

red skin lesions, often with a purple center

redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid

redness or soreness of the skin

seizures

severe stomach cramping

slow heartbeat

slow speech

sneezing

sores, welts, or blisters

stiff neck or back

tremor

trouble breathing

unusual bleeding or bruising

unusual weight gain or loss

upper right stomach pain

uterine cramping and bleeding

vomiting of material that looks like coffee grounds, severe and continuing

yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Belching

excess air or gas in the stomach or bowels

full feeling

passing gas

Less common

Breast pain

change in or loss of taste

confusion about identity, place, and time

constipation

continuing ringing or buzzing or other unexplained noise in the ears

decreased concentration

depression

difficulty in moving

dry mouth

frequent urge to defecate

increased clear or white vaginal discharge

irritability

itching of the vagina or genital area

lack or loss of strength

loss or thinning of hair

pain during sexual intercourse

seeing, hearing, or feeling things that are not there

straining while passing stool

thick, white vaginal discharge with no odor or with a mild odor

trouble sleeping

Incidence not known

Blemishes on the skin

decreased interest in sexual intercourse

inability to have or keep an erection

loss in sexual ability, desire, drive, or performance

pimples

sleepiness or unusual drowsiness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Robert Chad Hakim, PharmD, BCCCP, started his full-time career as a clinical pharmacist at UCLA Health in the general medicine, general cardiology, and ICU units after completing residency in 2016. He also was the preceptor for the general medicine rotation from 2017 to 2021, which was a required rotation for all pharmacy residents.
Kristianne Hannemann, PharmD, is a licensed pharmacist in California. She has been a retail pharmacy manager and staff pharmacist for over 7 years and has contributed drug information content to different health companies.

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