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Eltrombopag Coupon - Eltrombopag 50mg tablet

eltrombopag

Generic Promacta
Used for Anemia, Thrombocytopenia
Used for Anemia, Thrombocytopenia

Promacta (eltrombopag) is an oral medication used to treat specific blood-related conditions like immune thrombocytopenic purpura (ITP). It’s also used with other medications to raise platelet levels in people with long-term hepatitis C. Common side effects include nausea, fever, tiredness, and headache. Currently Promacta (eltrombopag) is a brand-name medication only, so generics aren't available on the market.

Reviewed by:
reviewer
Mason Davis
reviewer
Daisy Chau, PharmD
reviewer
Connie Zheng, PharmD
Last reviewed on April 10, 2023
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageInteractionsAlternativesLatest newsImagesReferencesPricesMedicare
basics-icon

What is Promacta (eltrombopag)?

What is Promacta (eltrombopag) used for?

  • Low platelet count in people with immune thrombocytopenic purpura (ITP) when other medications haven’t worked - adults and children

  • Low platelet count in people with long-term hepatitis C - adults only

  • Used alone or with other medications in people who can’t make enough blood cells (severe aplastic anemia) - adults and children

How Promacta (eltrombopag) works

Promacta (eltrombopag) is a thrombopoietin receptor (TPO) agonist, meaning it acts like TPO. TPO is a natural hormone that tells your bone marrow to make more blood cells.

By working like TPO, Promacta (eltrombopag) raises the level of platelets, red blood cells, and white blood cells in your body. This is important because having a healthy level of these components helps to lower your risk for bleeding, fight against infections, and makes sure enough oxygen is carried throughout your body.

Drug Facts

Common BrandsPromacta
Drug ClassThrombopoietin receptor agonist
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
basics-icon

What are the side effects of Promacta (eltrombopag)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Long-term ITP and severe/refractory aplastic anemia:
  • Nausea (4-33%)
  • Fever (9-14%)
  • Tiredness (5-28%)
  • Cough (9-23%)
  • Headache (10-21%)
  • Diarrhea (9-21%)
The risk of developing these side effects depends on your dose.Long-term hepatitis C:
  • Low red blood cell levels (anemia) (40%)
  • Fever (30%)
  • Tiredness (28%)
  • Headache (21%)
  • Nausea (19%)
  • Diarrhea (19%)
People with hepatitis C who reported side effects were also taking interferon and ribavirin together with Promacta (eltrombopag). All of the listed side effects for people with long-term hepatitis C might not be caused by Promacta (eltrombopag) alone.

Other Side Effects

  • Flu virus
  • Muscle pain
  • New or worsening cloudiness in the eye (cataracts)
  • Back pain
  • Tingling feeling

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Liver damage: stomach swelling, dark stool or urine, tiredness, confusion, and yellowing of the skin or eyes
  • Blood clot in the liver: nausea, vomiting, abdominal pain, and diarrhea
  • Other types of blood clots: legs, (redness, pain, tenderness, swelling of the skin), lungs (cough, difficulty breathing, chest pain), heart attack (chest pain, pain in the arms or shoulders, pain in the neck or jaw), stroke (difficulty speaking, numbness on one side of the body, confusion)

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Bloating or swelling of the face, arms, hands, lower legs, or feet

body aches or pain

chills

cough

difficulty with breathing

fever

headache

loss of voice

pain in the chest, groin, or legs, especially the calves

pale skin

rapid weight gain

runny nose

severe, sudden headache

slurred speech

sore throat

sudden loss of coordination

sudden, severe weakness or numbness in the arm or leg

tingling of the hands or feet

troubled breathing with exertion

unusual tiredness or weakness

unusual weight gain or loss

yellow eyes or skin

Less common

Bladder pain

blindness

blurred or decreased vision

bruising

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

diarrhea

general feeling of discomfort or illness

hoarseness

joint pain

lower back or side pain

muscle aches and pains

nausea

pinpoint red spots on the skin

redness of the eye

shivering

sweating

tender, swollen glands in the neck

trouble sleeping

trouble swallowing

voice changes

vomiting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Decreased appetite

difficulty with moving

hair loss or thinning of the hair

itching skin

lack or loss of strength

muscle cramps or stiffness

swollen joints

Less common

Back pain

belching

bone pain

darkening of the skin

dry mouth

heartburn

indigestion

rash

stomach discomfort, upset, or pain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Promacta (eltrombopag)

thumbs-up

Pros

Oral tablet taken once daily by mouth

Also available as an oral suspension, which is a good option for people who have trouble swallowing

Can be used in young children

No injection is required

thumbs-down

Cons

Risk of blood clots and liver damage

Is a specialty drug that might not be available at all local pharmacies

Might need to undergo many dose changes until the right dose is found

Oral suspension preparation and administration can be difficult for some people

pharmacist-tips

Pharmacist tips for Promacta (eltrombopag)

pharmacist

  • Promacta (eltrombopag) can be taken without a meal or with a meal that's low in calcium. Avoid taking it with foods high in calcium like cheese, yogurt, milk, spinach, and collard greens. It should also be taken 2 hours before or 4 hours after other medications. This is because certain foods and other medications can cause Promacta (eltrombopag) to not work as well as it should.

    • Promacta (eltrombopag) can cause blood clots to form since the medication stimulates the bone marrow to make more blood cells. Clots caused by Promacta (eltrombopag) are most often seen in the liver. Contact your healthcare provider if you start experiencing symptoms such as nausea, vomiting, abdominal pain, and diarrhea.

      • Promacta (eltrombopag) can also cause blood clots to form in your legs and lungs. If you start experiencing symptoms like redness, pain, and swelling in your legs, contact your healthcare provider as these could be signs of a blood clot in your legs. If you start experiencing chest pain, a cough, or difficulty breathing, contact your healthcare provider as these could be signs of a blood clot in your lungs.

        • If you stop taking Promacta (eltrombopag), your risk of bleeding is higher, especially if you’re taking blood thinners (e.g. warfarin (Coumadin) or Xarelto (rivaroxaban)). If you start to experience bruising, dark-colored stool and urine, or dizziness, contact your healthcare provider right away.

          • Don’t crush or split Promacta (eltrombopag) tablets. And don’t mix the tablets into food or drinks. Doing so will make the tablets not work as well. If you or your child have difficulty swallowing tablets, Promacta (eltrombopag) is also available as an oral suspension.

            • If you are taking the Promacta (eltrombopag) oral suspension, read the Instructions for Use before mixing the medication. The powder packets must be mixed with 20 mL of cold water. Don't mix the powder with hot water because it can damage the medication. The oral suspension needs to be taken within 30 minutes of mixing.

              faqs

              Frequently asked questions about Promacta (eltrombopag)

              What is immune thrombocytopenic purpura (ITP)?
              ITP is a condition that occurs when there aren’t enough platelets in your body. Platelets are a type of blood cell that’s responsible for forming a clot to stop bleeding. In ITP, your body mistakenly sees platelets as harmful cells, instead of normal clotting cells. Your body then attacks and destroys the platelets, which lowers your platelet count and puts you at risk for bleeding. Promacta (eltrombopag) works by raising your platelet levels, so you’re less likely to experience bleeding or bruising from ITP.
              Can you use Promacta (eltrombopag) if you have low platelet levels from other conditions besides ITP and hepatitis C?
              No. Treatment for low platelet levels can differ person to person, depending on the cause and the platelet levels. If your platelet levels are low, it's important to ask your healthcare provider to help you find the reason why. Promacta (eltrombopag) can only be used in people who haven’t responded well to other treatments for long-term ITP, people with long-term hepatitis C, and those who can’t make enough blood cells on their own (severe aplastic anemia).
              How is Promacta (eltrombopag) different from similar medications for ITP?
              Doptelet (avatrombopag) and Nplate (romiplostim) are other medications in the same class as Promacta (eltrombopag) that are also used to treat ITP. While Doptelet (avatrombopag) is only available as an oral tablet that’s taken daily and Nplate (romiplostim) is given as an injection once a week, Promacta (eltrombopag) is available as both an oral tablet and a powder for oral suspension to be taken daily.
              How long does it take for Promacta (eltrombopag) to work?
              It depends on what condition you're taking Promacta (eltrombopag) for. For example, for ITP it takes 1 to 2 weeks for your platelet levels to start rising. For severe and refractory aplastic anemia, it could take up to 4 months to see your platelet levels rise. For long-term hepatitis C, the time depends on if you’re taking other antiviral medications with Promacta (eltrombopag). In addition, your dose might need to be adjusted based on your platelet levels. If you have any questions about your platelet levels, ask your healthcare provider.
              Can you cut Promacta (eltrombopag) tablets?
              No, you'll need to swallow Promacta (eltrombopag) tablets whole. But luckily, the medication also comes in packets that you mix into an oral suspension to drink. This can be a good option for children and people who have difficulty swallowing. Talk to your healthcare provider if you prefer to take the oral suspension.
              How long does Promacta (eltrombopag) stay in your system?
              If you're taking Promacta (eltrombopag) for ITP, it takes about 5 to 7 days for the majority of the medication to leave your body. And for people who also have severe liver problems, it can take even longer. But keep in mind that this time frame is estimated based on the half-life of Promacta (eltrombopag). It can also be affected by your health conditions and genetics, so it can be different for each individual person. Discuss with your healthcare provider if you have questions about how long the medication stays in your body.
              Is Promacta (eltrombopag) safe to take while pregnant?
              Currently, there isn’t enough information to know if Promacta (eltrombopag) is safe to take during pregnancy. Animal studies have shown that Promacta (eltrombopag) can cause harm to unborn babies. Because of this risk, it’s recommended that if you're able to become pregnant, you should use some form of contraception while taking Promacta (eltrombopag). Contraception should also be used for at least 7 days after stopping Promacta (eltrombopag). Talk with your healthcare provider if you are or might become pregnant.
              Is Promacta (eltrombopag) safe to take while breastfeeding?
              Animal studies have shown that Promacta (eltrombopag) can be passed through breast milk, although whether it passes through breast milk in people is unknown. To be on the safe side, females shouldn't breastfeed while taking Promacta (eltrombopag). Ask your healthcare provider about other options that are safer to take while breastfeeding.
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              What are the risks and warnings for Promacta (eltrombopag)?

              Promacta (eltrombopag) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

              risk-warning

              Liver damage

              • Risk factors: Also taking interferon and ribavirin | History of liver problems

                Promacta (eltrombopag) can cause liver damage regardless of what it’s being used for. Your risk is higher if you have hepatitis C and are also taking interferon and ribavirin, medications that treat hepatitis C. Blood work must be done regularly to check your liver health. If you experience stomach swelling, darkening of the urine, yellowing of the skin or eyes, confusion, tiredness, or right upper stomach pain, contact your healthcare provider right away, because you might need to stop the medication.

                risk-warning

                Blood clots

                • Risk factors: Older than 65 years of age | Obesity | Lack of physical activity | History of clots | Smoking | Other medical conditions that raise your risk for clots | Taking higher doses of Promacta (eltrombopag)

                  Promacta (eltrombopag) can cause blood clots because it raises platelet levels. Additional risk factors for blood clots include smoking, age greater than 65 years old, history of blood clots, obesity, and lack of physical activity. You’ll need regular blood work done to not only check that the medication is working, but also to make sure you're not at risk for developing a blood clot. Blood clots linked with Promacta (eltrombopag) are mostly seen in the liver. If you start to experience symptoms like abdominal pain, nausea, vomiting, and diarrhea, get medical help right away because this could be a sign of a blood clot in your liver.

                  In addition, Promacta (eltrombopag) can also cause clots to form in other parts of the body, including your legs and lungs. If you start to experience swelling, redness, pain in your legs, difficulty breathing, chest pain, or a cough, contact your doctor right away. Clots in other parts of the body can lead to other problems including heart attack and stroke. If you experience chest pain, pain in the arms or shoulders, pain in the neck or jaw, difficulty speaking, numbness on one side of the body, or confusion, contact your healthcare provider right away.

                  risk-warning

                  Higher risk of serious blood cancer and death in people with myelodysplastic syndromes (MDS)

                  • Risk factors: People with MDS

                    People with MDS, a type of blood cancer, who take Promacta (eltrombopag) are at higher risk for developing a more serious type of blood cancer called acute myeloid leukemia (AML). which can lead to death. Let your healthcare provider know if you have any type of MDS or blood cancers before starting Promacta (eltrombopag).

                    risk-warning

                    Cataracts

                    • Risk factors: Older than 65 years of age | History of cataracts | Smoking | Diabetes | High blood pressure | History of eye injury | Taking steroids for a long period of time

                      People taking Promacta (eltrombopag) could develop new or worsening cataracts, or cloudiness in the eye. You are at a higher risk of developing cataracts if you are older than 65 years of age, are a current smoker, have high blood pressure, have diabetes, or if you’ve taken steroids for a long period of time. You’re recommended to get an eye exam before starting Promacta (eltrombopag) and then regularly throughout treatment. If you start experiencing symptoms like blurry vision, difficulty seeing at night, or double vision, contact your healthcare provider.

                      dosage

                      Promacta (eltrombopag) dosage forms

                      Typical dosing for Promacta (eltrombopag)

                      Low platelet count in people with long-term ITP:

                      • Adults and children ages 6 and older: The typical starting dose is 50 mg by mouth once daily.

                      • Children ages 1 to 5 years old: The typical starting dose is 25 mg by mouth once daily.

                      Your healthcare provider will adjust your dose based on your platelet levels. The maximum dose is 75 mg a day. Your dose might be lowered if you’re of East Asian or Southeast Asian descent, or if you have liver problems.

                      Low platelet count in people with long-term hepatitis C:

                      • The typical starting dose is 25 mg by mouth once daily. Your healthcare provider will adjust your dose based on your platelet levels. The maximum dose is 100 mg a day.

                      Severe aplastic anemia as a first-choice treatment:

                      • Adults and children ages 12 and older: The typical starting dose is 150 mg by mouth once daily for 6 months.

                      • Children ages 6 to 11 years old: The typical starting dose is 75 mg by mouth once daily for 6 months.

                      • Children ages 2 to 5 years old: The starting dose will depend on your child’s weight. The typical starting dose is 2.5 mg/kg by mouth once daily for 6 months.

                      Your dose might be lowered if you’re of East Asian or Southeast Asian descent, or if you have liver problems.

                      Severe aplastic anemia that hasn’t responded to treatment (refractory):

                      • Adults and children ages 2 and older: The typical starting dose is 50 mg by mouth once daily.

                      Your healthcare provider will adjust your dose based on your platelet levels. The maximum dose is 150 mg a day. Your dose might be lowered if you’re of East Asian or Southeast Asian descent, or if you have liver problems.

                      interactions

                      Interactions between Promacta (eltrombopag) and other drugs

                      Promacta (eltrombopag) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Promacta (eltrombopag). Please note that only the generic name of each medication is listed below.

                      Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                      • Elagolix
                      • Grazoprevir

                      Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                      • Alpelisib
                      • Aluminum
                      • Berotralstat
                      • Calcium
                      • Eluxadoline
                      • Iron
                      • Magnesium
                      • Ozanimod
                      • Pexidartinib
                      • Pixantrone
                      • Revefenacin
                      • Rimegepant
                      • Selenium
                      • Simvastatin
                      • Topotecan
                      • Ubrogepant
                      • Zinc

                      Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                      alternatives

                      What are alternatives to Promacta (eltrombopag)?

                      There are a number of medications that your doctor can prescribe in place of Promacta (eltrombopag). Compare a few possible alternatives below.
                      Promacta (eltrombopag)
                      Used for:

                      • Low platelet count in people with immune thrombocytopenic purpura (ITP) when other medications haven’t worked - adults and children

                      • Low platelet count in people with long-term hepatitis C - adults only

                      • Used alone or with other medications in people who can’t make enough blood cells (severe aplastic anemia) - adults and children

                      View Prices
                      Doptelet (avatrombopag)
                      Used for:

                      • Low platelet levels in adults with chronic liver disease (CLD) before a scheduled procedure

                      • Low platelet levels in adults with chronic immune thrombocytopenia (ITP) when other medications haven’t worked

                      View Prices
                      Mulpleta (lusutrombopag)
                      Used for:

                      • Treatment of low platelets in adults with long-term liver disease scheduled to undergo a procedure

                      $8371.38 Lowest GoodRx priceView Prices
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                      Promacta (eltrombopag) images

                      White Round E12 And H - Eltrombopag 50mg Tablet
                      This medicine is White, Round Tablet Imprinted With "H" And "E12".White Round E12 And H - Eltrombopag 50mg Tablet

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                      References

                      Best studies we found

                      American Cancer Society. (2018). What is acute myeloid leukemia (AML)?

                      American Heart Association. (2023). Understand your risk for excessive blood clotting.

                      Aplastic Anemia and MDS International Foundation. (n.d.). Aplastic anemia.

                      View All References (8)

                      Aplastic Anemia and MDS International Foundation. (n.d.). MDS - Myelodysplastic syndromes.

                      Dietary Guidelines for Americans. (n.d.). Food sources of calcium.

                      Gilreath, J., et al. (2021). Thrombopoietin receptor agonists (TPO-RAs): Drug class considerations for pharmacists. Drugs.

                      MedlinePlus. (2022). Immune thrombocytopenic purpura (ITP).

                      National Eye Institute. (2023). Cataracts.

                      National Heart, Lung, and Blood Institute. (2022). Thrombocytopenia.

                      Novartis Pharmaceuticals Corporation. (2023). Promacta- eltrombopag olamine tablet, film coated; eltrombopag olamine powder, for suspension [package insert]. DailyMed.

                      Yu, X., et al. (2014). Hypertension and risk of cataract: A meta-analysis. PLoS One.

                      GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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