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Amoxicillin for Dogs: A Common Antibiotic to Treat Bacterial Infections

Catherine Barnette, DVMGhanasyam Bey, DVM
Updated on September 18, 2024

Key takeaways:

  • Amoxicillin is an antibiotic that treats a variety of bacterial infections in dogs.

  • Amoxicillin is often combined with other antibiotics to provide broader treatment against a wide variety of bacteria. 

  • Amoxicillin doesn’t usually cause side effects in dogs. But if side effects occur, they may include loss of appetite, diarrhea, and vomiting. 

An owner is hand-feeding their dog a pill in a close-up.
miniseries/E+ via Getty Images

Amoxicillin (Amoxi-Tabs, Amoxil) is an antibiotic that’s commonly prescribed to humans. But it’s also very common in veterinary medicine. This antibiotic has been widely used to treat infections in both humans and pets for decades.

Although there are many new antibiotics, amoxicillin is still commonly used to treat dogs because it’s safe, effective, and affordable.

Amoxicillin for dogs at a glance

Common names

Amoxicillin (Amoxi-Tabs, Amoxil, Amoxi-Drop, Bimox, Moxatag, Novamoxin)

What it treats

Bacterial infections

How it comes (available forms)

Tablets, capsules, liquid suspension

Common side effects

Loss of appetite, diarrhea, nausea

Average cost

$4-$15 for 14 capsules 

An infographic explaining Amoxicillin for dogs, including its alternative names, uses, dosage forms, administration guidelines, and common side effects.

What is amoxicillin for dogs, and how does it work?

Amoxicillin is an antibiotic that kills bacteria by damaging their cell walls. Amoxicillin is effective against many different types of bacteria. So veterinarians use it to treat a wide variety of bacterial infections in dogs and other animals.

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Amoxicillin may be used alone or in combination with other antibiotics. For example, a common veterinary antibiotic, Clavamox, combines amoxicillin and clavulanic acid. Clavulanic acid increases amoxicillin’s effectiveness, allowing Clavamox to treat a wider range of infections.

What is amoxicillin used for in dogs?

Amoxicillin is used to treat a variety of infections in dogs, including: 

  • Bite wound infections 

  • Skin infections

  • Soft tissue infections

  • Gastrointestinal infections

  • Bone infections

  • Urinary tract infections

  • Respiratory infections

  • Leptospirosis

  • Lyme disease

However, amoxicillin can’t treat every bacterial infection because some bacteria are resistant to its effects.

Do not give your dog amoxicillin unless your veterinarian prescribes it. Giving your dog amoxicillin and other antibiotics inappropriately can contribute to antibiotic-resistant infections, like MRSA (methicillin-resistant Staphylococcus aureus).

What’s the standard amoxicillin dosage for dogs, and how is it given?

Your veterinarian will calculate the correct amoxicillin dosage for your dog using its weight and other factors. Give amoxicillin to your dog as directed by your veterinarian.

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Amoxicillin is usually given twice a day (every 12 hours). But your veterinarian may ask you to give the medication three times a day. Do not change the dose unless your veterinarian tells you to do so.

Common forms of amoxicillin include: 

  • Tablets

  • Capsules

  • Liquid suspension

You can store amoxicillin tablets and capsules at room temperature. Store liquid amoxicillin in the refrigerator.

What are common side effects of amoxicillin in dogs?

Most dogs tolerate amoxicillin well. But it can cause side effects. The most common side effects of amoxicillin in dogs include: 

You can give your dog their amoxicillin dose with food to reduce the risk of side effects. 

Call your veterinarian if your dog has frequent vomiting or diarrhea while taking amoxicillin. Your veterinarian may prescribe a different antibiotic for your dog’s infection or suggest how to minimize side effects.

Amoxicillin is considered safe to give to pregnant and nursing dogs. 

What are the most serious risks of amoxicillin for dogs?

A small number of dogs are allergic to amoxicillin and other penicillin antibiotics. Signs of an allergic reaction to amoxicillin may include: 

  • Skin rash

  • Hives

  • Swelling of the face or neck

  • Difficulty breathing


If your dog has an allergic reaction, stop giving them amoxicillin and contact your veterinarian immediately.

Other side effects, which are extremely rare, may include bone marrow suppression and fever

Contact your veterinarian if you have any concerns about these side effects.

Does amoxicillin interact with any other dog medications?

Amoxicillin is not known to interact harmfully with any other medications.

It’s often combined with other antibiotics to treat an infection. This allows your veterinarian to treat a wider range of bacteria. Combining amoxicillin with other antibiotics typically doesn’t cause harmful interactions or increased side effects.

Even though amoxicillin has no known interactions, talk to your veterinarian about your pet’s other medications before giving them the antibiotic. Let them know about all prescription medications, over-the-counter medications, and supplements your dog takes.

What should you do if your dog misses a dose of amoxicillin?

If you miss giving your dog a dose of amoxicillin, give them the missed dose as soon as you remember. But, if it’s almost time for your dog’s next dose, skip the missed one. Then, resume your dog’s normal medication schedule. Do not give your dog a double dose of amoxicillin.

Amoxicillin must be given on a set schedule to be effective. If you have trouble following the prescribed dosing schedule, talk to your veterinarian. They may recommend a different antibiotic that doesn’t require frequent doses. 

Frequently asked questions

Can you get amoxicillin over the counter for your dog?

No, amoxicillin is a prescription medication. Your veterinarian must prescribe amoxicillin for your dog.

Is pet amoxicillin the same as human amoxicillin?

The active ingredient in pet amoxicillin and the human version are the same. However, amoxicillin is prescribed differently for dogs than it is for people. That’s why you need a prescription from your veterinarian for amoxicillin.

Can a dog take human antibiotics?

No, you should not give your dog an antibiotic that was prescribed for a human. While the active ingredients may be the same, the dosing is different. Ask your veterinarian for an amoxicillin prescription to make sure your pet gets the right amount of antibiotic. 

The bottom line

Amoxicillin is a commonly prescribed antibiotic in both human and veterinary medicine. It can treat a relatively wide range of bacteria in dogs. And it can be safely combined with a variety of other antibiotics.

Most dogs experience few, if any, side effects of amoxicillin. When they do occur, side effects typically include diarrhea and a loss of appetite. Contact your veterinarian if you notice any side effects in your dog while it’s taking amoxicillin. 

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Why trust our experts?

Catherine Barnette, DVM
Catherine Barnette, DVM, is a small animal veterinarian with 14 years of experience providing preventive care, medical workups, and surgical services in a number of general veterinary practices. She also served on her county's board of health for several years and taught biology laboratories for college students.
Renée Fabian, MA
Renée Fabian is the senior pet health editor at GoodRx. She’s worked for nearly 10 years as a journalist and editor across a wide range of health and well-being topics.
Ghanasyam Bey, DVM
Reviewed by:
Ghanasyam Bey, DVM
Ghanasyam Bey, DVM, is from Cleveland, Ohio, and attended Princeton University for undergraduate studies. After a year of biology research at Duke University, he attended Ohio State College of Veterinary Medicine.

References

American Veterinary Medical Association. (n.d.). Antimicrobial use and resistance: FAQs for pet owners

Brooks, W. (2022). Amoxicillin (numerous brand names). Veterinary Partner.

View All References (5)

Brooks, W. (2022). Amoxicillin-clavulanic acid (clavamox, augmentin, clavacillin). Veterinary Partner.

Gwaltney-Brant, S. M. (2019). Antibiotic use in pets. Veterinary Partner.

Mercer, M. A. (2022). Use of penicillins in animals. Merck Veterinary Manual.

Plumb’s Veterinary Medication Guides. (n.d.). Amoxicillin/clavulanate

Zoetis Inc. (2021). Amoxi-Tabs - amoxicillin tablet, film coated [package insert]. DailyMed.

GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.

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