Hyophen
Hyophen is a combination medication that treats a variety of urinary symptoms, such as painful urination, bladder discomfort, and urgency, caused by irritation or infections. It isn't an antibiotic and cannot be used to treat a urinary tract infection (UTI).
What is Hyophen?
What is Hyophen used for?
Symptoms of irritative urination such as frequency, urgency, painful urination, and loss of bladder control
Urinary symptoms related to urinary tract infections (UTIs)
Urinary symptoms caused by medical procedures
How Hyophen works
Hyophen is a combination medication made of 5 different drugs, which all work differently.
Hyoscyamine sulfate relaxes the bladder muscle to limit bladder spasms and the urge to urinate.
Methenamine is broken down to formaldehyde in acidic urine, which kills bacteria and stops its growth.
Methylene blue works as an antiseptic, meaning it prevents growth of bacteria.
Phenyl salicylate works as a pain reliever.
Benzoic acid keeps your urine acidic to help methenamine break down into formaldehyde.
Drug Facts
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What are the side effects of Hyophen?
Common Side Effects
- Rapid heartbeat
- Blurred vision
- Dizziness
- Drowsiness
- Blue to blue-green urine or stools
- Redness of your skin (flushing)
- Difficult urination
- Cannot empty your bladder fully
- Dry mouth
- Nausea
- Vomiting
Serious Side Effects
- Serious allergic reaction: itching, rash, severe dizziness, swelling, or trouble breathing
Source: DailyMed
The following side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Blurry vision
- Change in the amount of urine
- Fast or irregular heartbeat
- Trouble passing urine
Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
Pros and cons of Hyophen
Pros
Combination of 5 medications that all work in different ways to relieve your urinary symptoms
Treats a variety of urinary symptoms
Cons
Needs to be taken 4 times per day
Can be more expensive because a generic version is not available
Generally not recommended in people older than 65
Cannot be used by children age 6 years and younger
Can interact with many drugs
Pharmacist tips for Hyophen
If you experience a rapid pulse, dizziness, or blurred vision, stop taking Hyophen right away and contact your provider. Don't drive or do things that require you to focus until you know how this medication makes you feel.
Hyophen can interact with many drugs, such as sulfamethoxazole/trimethoprim (Bactrim), fluoxetine (Prozac), and amitriptyline (Elavil), so it's important that you check with your provider or pharmacist if you need to space out timing of your medications. If Hyophen is taken at the same time as certain medications, it might not work as well or more side effects can occur.
You can have an allergic reaction to Hyophen if you've had a reaction to belladonna alkaloids, such as atropine and scopolamine (Transderm Scop), or salicylates, such as aspirin. Let your provider know if you've had allergies to these medications in the past.
Take Hyophen with or without food. Drink plenty of water after taking each dose to make sure your kidneys have good blood flow.
Store this medication at room temperature, in a container that will protect it from light.
Frequently asked questions about Hyophen
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What are the risks and warnings for Hyophen?
Hyophen can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Mental side effects
Risk factors: Age 65 years and older
Older adults might experience excitement, agitation, drowsiness, or confusion while taking Hyophen. Let your provider know if this becomes bothersome.
Allergic reactions
Risk factors: Allergic reaction to belladonna alkaloids or salicylates
You can have an allergic reaction to Hyophen if you've had a reaction to belladonna alkaloids, such as atropine and scopolamine (Transderm Scop), or salicylates, such as aspirin. Let your provider know if you've had allergies to these medications in the past.
Stomach problems
Risk factors: Stomach ulcer
Hyophen can slow down your digestion. This can cause problems if you have a stomach ulcer. Let your provider know if you're being treated for a stomach ulcer before you start taking Hyophen.
Long-term use
It isn't known if it's safe to take Hyophen for a prolonged period of time. It’s important for you and your provider to weigh the risk and benefits of taking this medication long-term.
Hyophen dosage forms
| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 81.6mg/0.12mg | 30 tablets | $84.00 | $2.80 |
Typical dosing for Hyophen
Each Hyophen tablet contains 81.6 mg of methenamine, 9 mg of benzoic acid, 36.2 mg of phenyl salicylate, 10.8 mg of methylene blue, and 0.12 mg of hyoscyamine sulfate.
Adults:
The typical dose is 1 tablet by mouth 4 times per day with plenty of fluids.Children (older than 6 years):
The dose will depend on the child's individual needs.
Children 6 years old and younger shouldn't take Hyophen.
How much does Hyophen cost?
What are alternatives to Hyophen?
Symptoms of irritative urination such as frequency, urgency, painful urination, and loss of bladder control
Urinary symptoms related to urinary tract infections (UTIs)
Urinary symptoms caused by medical procedures
Relief of urinary pain, burning, urgency, and frequency caused by infection, trauma, catheter use, or surgery
Symptoms of irritative urination such as frequency, urgency, painful urination, and loss of bladder control
Urinary symptoms related to urinary tract infections (UTIs)
Urinary symptoms caused by medical procedures
Hyophen images
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