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HomeHealth TopicDermatology

Retinol and Vitamin C: How to Combine These Two Powerful Anti-Aging Ingredients

Maria Robinson, MD, MBASophie Vergnaud, MD
Published on November 20, 2024

Key takeaways:

  • Retinol and vitamin C are two ingredients with proven skin care benefits. They improve skin texture and reduce the appearance of fine lines and dark spots. 

  • You can use vitamin C together with retinol to magnify their benefits. The trick is to use them in the correct order to minimize side effects like redness and peeling.

  • For best results, use vitamin C in the morning and retinol in the evening. Use them after washing with a mild cleanser and before applying moisturizer. 

Older woman evening skincare routine.
RicardoImagen/E+ via Getty Images

Retinol and vitamin C are two of the most commonly talked about skin care ingredients, and with good reason. They improve skin tone and texture and reduce the natural signs of skin aging. 

If you’re wondering whether you can combine these two hero ingredients, you’ve come to the right place. Here, we’ll answer all your questions about using retinol and vitamin C together, including how to do it and why it’s a good idea. 

Can you use vitamin C and retinol together?

Yes, it’s possible to combine vitamin C and retinol into your regular skin care routine. But to maximize benefits and minimize side effects, you have to use these products in the right way. 

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The best way to combine these two ingredients is by using vitamin C in the morning and retinol at night. 

Vitamin C is best used in the morning because it can also help protect your skin from ultraviolet (UV) damage encountered during the day. 

Retinol is best used at night because some formulations are broken down by UV light.

What are the benefits of combining vitamin C and retinol?

Vitamin C and retinol are two of the most studied and most effective ingredients for skin health. They each have many proven anti-aging effects. But they work differently on your skin. Using them together magnifies their many benefits. 

Benefits of vitamin C

Vitamin C is an antioxidant that helps prevent and repair damage caused by UV light and other toxins. It does this by fighting free radicals — unstable molecules that damage your skin and lead to signs of aging, like fine lines and wrinkles, dark spots, and loss of skin elasticity.

Some ways vitamin C works in your skin include: 

  • Supporting collagen production

  • Fading dark spots

  • Replenishing vitamin E levels (another strong antioxidant) 

  • Boosting the benefit of sunscreen

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Benefits of retinol

Retinol is a form of vitamin A that’s added to many over-the-counter (OTC) skin care products. 

Retinoids, which are stronger forms of retinol, are available by prescription (except for Differin, which is OTC).

Retinol and retinoids have many skin benefits, including: 

  • Exfoliating the skin

  • Boosting collagen production

  • Minimizing the appearance of fine lines and wrinkles

  • Fading dark spots

  • Improving skin tone and texture

Choosing the right products

With so many products available, it helps to know which formulations are worth the investment. A more expensive product doesn’t mean a better one.

For best results with vitamin C, look for products with a concentration between 10% and 20% and packaged in dark, airtight containers (vitamin C degrades easily when exposed to light and air). 

When choosing a retinol, there are some things to keep in mind. 

First, if you’ve never used one before, choose a low concentration. Retinol 0.2% is a good place to start. Retinol can be listed under a few different names. Here are some to look for, listed from weakest to strongest:

  • Retinyl esters

  • Retinol

  • Retinaldehyde

  • Retinoid (Adapalene 0.1%)

Second, choose products that are suitable for your skin type

  • For dry skin, choose a hydrating cream with ingredients like hyaluronic acid and ceramides.

  • For combination skin, opt for a serum or a lightweight cream.

  • For oily skin, serums and gels are best.

How to combine retinol and vitamin C

Once you’ve got your products, here’s how to combine them safely to get the most out of their benefits. 

Morning skin care routine

In the morning:

  1. Wash with a gentle cleanser.

  2. After your skin dries, apply your vitamin C product and let it absorb completely. 

  3. Moisturize.

  4. Apply sunscreen.

Evening skin care routine

Before bed:

  1. Wash with a gentle cleanser.

  2. Optional: If your skin is very dry or sensitive, apply moisturizer before the retinol.

  3. After your skin dries, apply your retinol product and let it absorb.

  4. Moisturize.

Can combining vitamin C and retinol cause side effects?

Yes, combining vitamin C and retinol is more likely to cause side effects than using either product alone. That’s because both products can cause skin irritation. 

Most commonly, side effects people experience include: 

  • Skin redness

  • Pain and tingling

  • Itchiness

  • Flaking

But using these products correctly minimizes the risk of skin irritation. 

If you have dry or sensitive skin, use caution when starting vitamin C and retinol. It’s best to start with one product at a time and let your skin adapt before adding the other.

Frequently asked questions

What should you avoid if you’re using retinol?

Retinol can cause skin irritation and sensitivity, especially when you first start using it. So, it’s a good idea to avoid other harsh products, including:

  • Alpha and beta hydroxy acids (like glycolic and salicylic acids)

  • Benzoyl peroxide (like in acne washes or creams) 

  • Physical exfoliators (like facial scrubs and hard sponges)

Once your skin is tolerating the retinol, you can try adding in other products. It’s best to do this slowly. Add new products in one at a time, and start by using them on alternating days. 

What strength retinol should I start with?

If you’ve never used retinol before, it’s best to start with a lower-strength OTC product, like retinol 0.2%. This will help your skin get used to it. Once you’re tolerating this daily, you can work your way up to higher strengths. 

How do I layer other products with vitamin C and retinol?

It depends on the product you’re layering. If it’s something potentially irritating — like salicylic acid — then you should avoid using them together at first. 

Keep in mind: the stronger the retinol product, the higher the risk of irritation when combined with other products. Once your skin is used to the retinol, try alternating it with other products on different days. 

For hydrating products, like hyaluronic acid, you can use these after applying vitamin C or retinol. If you’re not sure how to apply a certain product, a dermatologist can advise you.

The bottom line

Using both vitamin C and retinol can be better than using just one. Both ingredients can improve skin tone and texture, reduce fine lines and wrinkles, and even out skin discoloration. But they work in different ways. Using them together can magnify their effects.

If you want to incorporate both vitamin C and retinol into your daily skin care routine, there’s a right and a wrong way to do this. For best results, use vitamin C in the morning and retinol at night. Don’t skip on the basics like moisturizer and sunscreen.

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Why trust our experts?

Maria Robinson, MD, MBA
Maria Robinson, MD, MBA, is a board-certified dermatologist and dermatopathologist who has practiced dermatology and dermatopathology for over 10 years across private practice, academic, and telehealth settings. She is a fellow of the American Academy of Dermatology and the American Society of Dermatopathology.
Sophie Vergnaud, MD
Sophie Vergnaud, MD, is the Senior Medical Director for GoodRx Health. An experienced and dedicated pulmonologist and hospitalist, she spent a decade practicing and teaching clinical medicine at academic hospitals throughout London before transitioning to a career in health education and health technology.

References

Al-Niami, F., et al. (2017). Topical vitamin C and the skin: Mechanisms of action and clinical applications. Journal of Clinical and Aesthetic Dermatology

Lau, M., et al. (2024). Cosmeceuticals for antiaging: A systematic review of safety and efficacy. Archives of Dermatological Research

View All References (2)

Pinnell, S. R., et al. (2001). Topical L-ascorbic acid: Percutaneous absorption studies. Dermatologic Surgery

Zasada, M., et al. (2019). Retinoids: Active molecules influencing skin structure formation in cosmetic and dermatological treatments. Advances in Dermatology and Allergology

GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.

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