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Brexafemme

ibrexafungerp
Used for Candidiasis
Used for Candidiasis

Brexafemme (ibrexafungerp) is an antifungal that's used to treat vaginal yeast infections in adults and children who've started having menstrual periods. This medication can also help lessen the risk of having a vaginal yeast infection again. In general, the dose is 2 tablets by mouth twice a day for 1 day. Side effects of Brexafemme (ibrexafungerp) include diarrhea, nausea, and stomach pain. This medication has a risk of harming an unborn baby.

Reviewed by:
reviewer
Cydnee Ng, PharmD
reviewer
Ashley Wong, PharmD
Last reviewed on May 5, 2024
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageCostContraindicationsAlternativesLatest newsReferencesPricesMedicare
basics-icon

What is Brexafemme (ibrexafungerp)?

What is Brexafemme (ibrexafungerp) used for?

How Brexafemme (ibrexafungerp) works

Brexafemme (ibrexafungerp) is a triterpernoid antifungal. This type of antifungal kills the fungus that's causing the yeast infection by blocking it from making an essential protein it needs for survival.

Drug Facts

Common BrandsBrexafemme
Drug ClassAntifungal
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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Avg retail price
$658.81(save 19.00%)
GoodRx discount
$533.63
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What are the side effects of Brexafemme (ibrexafungerp)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Diarrhea (17%)
  • Nausea (12%)
  • Stomach pain (11%)

Other Side Effects

  • Dizziness
  • Headache
  • Vomiting
  • Gas
  • Back pain
  • Menstrual cramps
  • Vaginal bleeding
  • Rash

Source: DailyMed

pros-and-cons

Pros and cons of Brexafemme (ibrexafungerp)

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Pros

Only need to take for one day to treat vaginal yeast infection

Only need to take once a month to help lessen recurrent infections

Can provide symptom relief for at least 4 weeks after a dose

thumbs-down

Cons

Need to take twice in a day

Can't take during pregnancy

Need to use birth control if you can become pregnant because of the risk of harm to an unborn baby

pharmacist-tips

Pharmacist tips for Brexafemme (ibrexafungerp)

pharmacist

  • Each Brexafemme (ibrexafungerp) blister pack contains 4 tablets, which is enough medication for a one-day course of treatment.

    • Take 2 tablets of Brexafemme (ibrexafungerp) by mouth in the morning and 2 tablets in the evening (about 12 hours apart). If you take the first 2 tablets in the afternoon or evening, take the other 2 tablets the next morning.

      • You can take Brexafemme (ibrexafungerp) with or without food. Taking it with food can help lessen stomach upset from the medication.

        • If you're able to become pregnant, be sure to use reliable birth control while you're taking Brexafemme (ibrexafungerp). Continue to use birth control for four more days after you take your last dose of the medication. This helps prevent pregnancy, which is important because the medication can cause harm to an unborn baby. Ask your primary care provider for options if you're not currently taking birth control.

          • Diarrhea is a common side effect of Brexafemme (ibrexafungerp). Be sure to drink plenty of fluids if you start having diarrhea after you take this medication to prevent getting dehydrated. Speak with your primary care provider if diarrhea becomes bothersome.

            • Let your healthcare team and pharmacist know what over-the-counter and prescription medications and supplements you're taking. Brexafemme (ibrexafungerp) can interact with certain medications. These interactions might make Brexafemme (ibrexafungerp) work less well for you or put you at risk for side effects. Your healthcare team can make sure all your medications are safe for you to take together.

              faqs

              Frequently asked questions about Brexafemme (ibrexafungerp)

              How long does Brexafemme (ibrexafungerp) take to work?
              In studies, most people reported complete relief of their vaginal yeast infection symptoms, like redness, itching, irritation, and burning, 1 to 2 weeks after taking Brexafemme (ibrexafungerp). In addition, most people felt continued symptom relief even 3 to 4 weeks after they took the medication.
              How long does Brexafemme (ibrexafungerp) stay in your system?
              In general, a dose of Brexafemme (ibrexafungerp) stays in your system for about 4 to 5 days. This time frame is based on the half-life of Brexafemme (ibrexafungerp), which is an estimate of the time it takes for your body to remove the medication from its system.
              Can children take Brexafemme (ibrexafungerp)?
              Children who've started having menstrual periods can take Brexafemme (ibrexafungerp). We don't know whether the medication works well or whether it's safe for children who haven't started their periods. Talk to your child's pediatrician to see what options are available for vaginal symptoms if your child hasn't started their periods yet.
              Can you drink alcohol while you're taking Brexafemme (ibrexafungerp)?
              The manufacturer doesn't say whether it's safe to drink alcohol while you're taking Brexafemme (ibrexafungerp). In general, drinking too much alcohol can affect how well your immune system can help fight your vaginal yeast infection. Speak with your primary care provider about your drinking habits and whether Brexafemme (ibrexafungerp) is appropriate and safe for you.
              Why do you have to use birth control while you're taking Brexafemme (ibrexafungerp)?
              If you're able to become pregnant, it's important to use birth control during treatment with Brexafemme (ibrexafungerp) because the medication has the potential to harm an unborn baby if you take it while pregnant. Use birth control for the entire 6-month treatment period if you're taking Brexafemme (ibrexafungerp) to lessen recurrent vaginal yeast infections. Continue to use birth control for four days after your last dose of Brexafemme (ibrexafungerp). Birth control helps prevent pregnancy and lowers the risk of harm to an unborn baby if it gets exposed to the medication in the womb.
              What should you do if you become pregnant while you're taking Brexafemme (ibrexafungerp)?
              You're encouraged to report your pregnancy to the manufacturer (Scynexis) at 1-888-982-7299 if you find out that you're pregnant during treatment with Brexafemme (ibrexafungerp) or within four days of your last dose of the medication. The manufacturer has an optional pregnancy safety study that monitors your health and your baby's health. This is important because animal studies suggest that Brexafemme (ibrexafungerp) might have a risk of harming an unborn baby if it's taken during pregnancy.
              What's the difference between Brexafemme (ibrexafungerp) and fluconazole (Diflucan)?
              Brexafemme (ibrexafungerp) and fluconazole (Diflucan) are different types of antifungals that can be used to treat vaginal yeast infections. The CDC regards fluconazole (Diflucan) as a first-choice option for treating vaginal yeast infections. In addition, you need to take 2 tablets of Brexafemme twice a day for 1 day. But for fluconazole (Diflucan), you just need to take 1 tablet of the medication once. Although Brexafemme is also approved to help lessen recurrent yeast infections, fluconazole (Diflucan) isn't. Speak with your primary care provider to help you compare the two medications.
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              What are the risks and warnings for Brexafemme (ibrexafungerp)?

              Brexafemme (ibrexafungerp) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

              risk-warning

              Harm to an unborn baby

              Brexafemme (ibrexafungerp) has the potential to cause serious harm to an unborn baby. In animal studies, Brexafemme (ibrexafungerp) caused rare birth defects and malformations. It's not known whether this risk applies to humans. But to be safe, you shouldn't take Brexafemme (ibrexafungerp) if you're pregnant.

              If you can become pregnant, you'll need to take a pregnancy test before each dose of Brexafemme (ibrexafungerp). The results must be negative to make sure you're not pregnant. You'll also need to use birth control while you're taking Brexafemme (ibrexafungerp). Be sure to use birth control during the 6-month treatment period for recurrent vaginal yeast infections. Continue to use birth control for four more days after your last dose of the medication.

              If you accidentally take Brexafemme (ibrexafungerp) while pregnant or find out that you're pregnant within four days of taking the medication, it's encouraged that you report your pregnancy to the manufacturer (Scynexis) at 1-888-982-7299. There's an optional pregnancy safety study that you can enroll in that monitors your health and your baby's health.

              dosage

              Brexafemme (ibrexafungerp) dosage forms

              The average cost for 1 carton of 4 tablets of 150mg of Brexafemme (ibrexafungerp) is $533.63 with a free GoodRx coupon. This is 19% off the average retail price of $658.81.
              carton
              Carton
              DosageQuantityPrice as low asPrice per unit
              4 tablets of 150mg1 carton$533.63$533.63

              Typical dosing for Brexafemme (ibrexafungerp)

              Each tablet contains 150 mg of ibrexafungerp.

              • Treatment of vaginal yeast infection: The typical dose is 2 tablets by mouth in the morning and 2 tablets in the evening (about 12 hours apart) for 1 day.

              • Lower the risk of having a vaginal yeast infection again: The typical dose is 2 tablets by mouth in the morning and 2 tablets in the evening (about 12 hours apart) once a month for 6 months.

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              How much does Brexafemme (ibrexafungerp) cost?

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              Brexafemme (brand)
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              contraindications-icon

              Brexafemme (ibrexafungerp) contraindications

              Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Brexafemme (ibrexafungerp) will not be safe for you to take.

              • Currently pregnant

              alternatives

              What are alternatives to Brexafemme (ibrexafungerp)?

              There are a number of medications that your doctor can prescribe in place of Brexafemme (ibrexafungerp). Compare a few possible alternatives below.
              Brexafemme (ibrexafungerp)
              Used for:
              $533.63 Lowest GoodRx priceView Prices
              Monistat (miconazole)
              Used for:

              • Treatment of vaginal yeast infection

              • Relief of vaginal yeast infection symptoms (itching and irritation outside of the vagina)

              $6.07 Lowest GoodRx priceView Prices
              Fluconazole (Diflucan)
              Used for:
              $11.22 Lowest GoodRx priceView Prices

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              References

              Best studies we found

              Centers for Disease Control and Prevention. (2021). Vulvovaginal candidiasis (VVC).

              Goje, O., et al. (2023). Oral ibrexafungerp for vulvovaginal candidiasis treatment: An analysis of VANISH 303 and VANISH 306. Journal of Women's Health. 

              Jallow, S., et al. (2021). Ibrexafungerp: A first-in-class oral triterpenoid glucan synthase inhibitor. Journal of Fungi.

              View All References (2)

              Phillips, N. A., et al. (2023). Ibrexafungerp for the treatment of vulvovaginal candidiasis: Design, development and place in therapy. Drug Design, Development and Therapy.

              Scynexis, Inc. (2022). Brexafemme- ibrexafungerp tablet, film coated [package insert]. DailyMed.

              GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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