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Zulresso

brexanolone
Used for Postpartum Depression
Used for Postpartum Depression

Zulresso (brexanolone) is a newer injectable medication used to treat postpartum depression. It's infused through the veins and the infusion takes about 2 and a half days. There's a risk that you might get very drowsy or suddenly pass out while getting Zulresso (brexanolone), so you'll be closely monitored by your healthcare provider during treatment. It's available as a brand-name medication only, which can be expensive.

Reviewed by:
reviewer
Robert Chad Hakim, PharmD, BCCCP
reviewer
Kristianne Hannemann, PharmD
Last reviewed on May 24, 2022
BasicsWarningsFAQsAlternativesLatest newsPricesMedicare
Zulresso (brexanolone) is a controlled substance, which means that it's more likely to be misused or cause dependence. There are federal and state laws that limit the amount of medication that can be prescribed or dispensed within a certain period of time.
basics-icon

What is Zulresso (brexanolone)?

What is Zulresso (brexanolone) used for?

  • Depression that happens after childbirth (postpartum depression)

How Zulresso (brexanolone) works

Drug Facts

Common BrandsZulresso
Drug ClassGABA modulator
Controlled Substance ClassificationSchedule IV
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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What are the risks and warnings for Zulresso (brexanolone)?

Zulresso (brexanolone) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

risk-warning

Excessive sleepiness and loss of consciousness

  • Risk factors: Alcohol use | Taking other medications that cause sleepiness

    Zulresso (brexanolone) can make you very sleepy, which can affect your ability to focus, think, or react, and even cause you to lose consciousness. This side effect is more likely to happen or be more intense if you drink alcohol or take other medications that cause sleepiness (e.g., opioids, benzodiazepines, sleep medications) while receiving Zulresso (brexanolone). Your provider will monitor you for excessive sleepiness and adjust your dose or stop your medication, if needed. Don't drive or operate machinery until your feeling of sleepiness from Zulresso (brexanolone) has completely gone away.

    risk-warning

    Zulresso Risk Evaluation and Mitigation Strategy (REMS)

    Since Zulresso (brexanolone) can make you very sleepy and potentially lose consciousness, it's only available through a drug safety program called the Zulresso REMS. All hospitals or facilities that can give Zulresso (brexanolone), pharmacies that dispense Zulresso (brexanolone), and mothers who take Zulresso (brexanolone) must be registered with the REMS program. This is to make sure the medication is distributed and given under the safest conditions possible for you.

    risk-warning

    Suicidal thoughts and behaviors

    • Risk factors: History of depression | Ages 18 to 24 years old

      Antidepressant medications like Zulresso (brexanolone) can cause suicidal thoughts and behaviors. Symptoms include thoughts of harming yourself, depression, and aggressive behavior. This can happen to anyone taking Zulresso (brexanolone), but the risk is higher if you have a history of depression or if you're 18 to 24 years old. Let your provider know if you or your loved ones notice a change in your mood or behavior, or if you have thoughts of hurting yourself while, or soon after, receiving Zulresso (brexanolone).

      faqs

      Frequently asked questions about Zulresso (brexanolone)

      What is Zulresso (brexanolone) used for?
      Zulresso (brexanolone) is used for the treatment of postpartum depression (PPD). PPD is when the mother develops depression after the birth of her baby. PPD is a common problem and happens to one in every nine mothers. Your provider will screen you for PPD after you give birth and if your results are positive, you might be eligible to receive Zulresso (brexanolone).
      Why is Zulresso (brexanolone) part of the Risk Evaluation and Mitigation Strategies (REMS) drug safety program?
      Zulresso (brexanolone) is part of a drug safety program because it can put you at risk for serious side effects, such as passing out or feeling extremely drowsy. If you're prescribed this medication, you must register through the Risk Evaluation and Mitigation Strategies (REMS) Program. All providers, pharmacies, and healthcare facilities that care for you while you receive this medication also must register with Zulresso (brexanolone) REMS. This program makes sure that you and your providers are aware of the serious side effects with this medication and know what to do if they appear.
      How does Zulresso (brexanolone) work?
      It's not exactly known how Zulresso (brexanolone) works to help mothers with PPD, but it's thought to work by balancing certain chemicals in your brain involved with mood.
      What is the dose of Zulresso (brexanolone)?
      The dose of Zulresso (brexanolone) depends on your weight and will be given as a continuous intravenous (IV) infusion over 60 hours (2 and a half days). Your provider will first start you on a low dose, then slowly raise the dose depending on how you're responding to the medication. When it's close to the time to end your infusion, your provider will slowly lower the dose before completely stopping the medication. You won't be able to receive Zulresso (brexanolone) if you have severe kidney problems because one of the inactive ingredients in the medication can build up to harmful levels in your body.
      What should I expect during my Zulresso (brexanolone) infusion?
      You'll get your Zulresso (brexanolone) infusion at a certified hospital or treatment center. Each infusion will take about 2 and a half days. You'll probably be able to receive visits from loved ones during the infusion, but you should arrange for full-time childcare for this time. During your treatment, a trained healthcare provider will check on you every 2 hours while you're awake to look for signs of extreme drowsiness. They'll put a monitor on your finger to check your pulse and oxygen level. If you feel like you can't stay awake when you're supposed to be awake, or if you think you're going to black out, let your provider know right away because they might need to pause your infusion.
      What are some common side effects of Zulresso (brexanolone)?
      Some possible side effects include sleepiness, dizziness, and dry mouth. Less common side effects include diarrhea, flushing (feeling warm all of a sudden), and passing out (see risks and warnings section for more information).
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      alternatives

      What are alternatives to Zulresso (brexanolone)?

      There are a number of medications that your doctor can prescribe in place of Zulresso (brexanolone). Compare a few possible alternatives below.
      Zulresso (brexanolone)
      Used for:

      • Depression that happens after childbirth (postpartum depression)

      View Prices
      Bupropion
      Used for:

      • Depression

      • Seasonal affective disorder (SAD) - only bupropion HCl extended-release (Wellbutrin XL)

      $10.26 Lowest GoodRx priceView Prices
      Sertraline (Zoloft)
      Used for:
      $9.60 Lowest GoodRx priceView Prices

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