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rosuvastatin / ezetimibe

Generic Roszet
Used for High Cholesterol
Used for High Cholesterol

Roszet (rosuvastatin / ezetimibe) is a combination of two different medications that work to lower cholesterol in different ways. The medication is conveniently taken by mouth once a day. And it's available as a generic, which tends to be less expensive.

Reviewed by:
reviewer
Robert Chad Hakim, PharmD, BCCCP
reviewer
Allison Gourley, PharmD
Last reviewed on September 26, 2022
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageCostContraindicationsAlternativesLatest newsPricesMedicare
basics-icon

What is Roszet (rosuvastatin / ezetimibe)?

What is Roszet (rosuvastatin / ezetimibe) used for?

How Roszet (rosuvastatin / ezetimibe) works

Roszet (rosuvastatin / ezetimibe) is a combination of two medications that work together to lower cholesterol levels.

  • Rosuvastatin is a statin. It helps to lower "bad" cholesterol (called LDL) by blocking you liver from making cholesterol.

  • Ezetimibe is a cholesterol absorption inhibitor. It blocks the amount of cholesterol that your body absorbs.

Are you looking for information on rosuvastatin (Crestor) alone, ezetimibe (Zetia) alone, or Vytorin (ezetimibe / simvastatin) instead?

Drug Facts

Common BrandsRoszet
Drug ClassStatin / Cholesterol absorption inhibitor
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
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Avg retail price
$324.62(save 21.06%)
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$256.26
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What are the side effects of Roszet (rosuvastatin / ezetimibe)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Inflammation of nasal passages (4%)
  • Muscle pain (3%)
  • Upper respiratory tract infection (3%)
  • Joint pain (3%)
  • Diarrhea (3%)

Other Side Effects

  • Back pain
  • Pain in arms and legs
  • Tiredness

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Severe muscle damage (Rhabdomyolysis): Dark brown urine, severe muscle weakness or pain, fever, tiredness
  • Worsening liver problems or liver failure: swelling of your stomach, yellowing of your skin or the whites of your eyes, confusion, dark or brown urine

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • High blood sugar (hyperglycemia)—increased thirst or amount of urine, unusual weakness or fatigue, blurry vision
  • Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
  • Muscle injury—unusual weakness or fatigue, muscle pain, dark yellow or brown urine, decrease in amount of urine

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Roszet (rosuvastatin / ezetimibe)

thumbs-up

Pros

Taken once a day by mouth

More convenient to take a single pill containing two medications that work in different ways

Available as a lower-cost, generic form

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Cons

Maybe more difficult to customize the dose since it's a fixed combination of two medications

Can cause serious liver problems

Can cause rhabdomyolysis, a life-threatening muscle problem that's a medical emergency

pharmacist-tips

Pharmacist tips for Roszet (rosuvastatin / ezetimibe)

pharmacist

  • Roszet (rosuvastatin / ezetimibe) can be taken with or without food. Make sure you swallow the tablet whole. Don't cut or crush the tablet because it can affect how the medication works.

    • Take Roszet (rosuvastatin / ezetimibe) at the same time every day, either in the morning or night. If you accidentally miss a dose, skip that dose and take your next dose at your regularly scheduled time.

      • Limit your use of alcohol while taking Roszet (rosuvastatin / ezetimibe). This is because alcohol can raise the risk of serious liver problems associated with Roszet (rosuvastatin / ezetimibe).

        • Roszet (rosuvastatin / ezetimibe) can interact with a lot of commonly used medications like cyclosporine (Sandimmune or Neoral) and fibrates. Make sure to tell your provider about all of the medications you're taking. Taking some medications together with Roszet (rosuvastatin / ezetimibe) can affect medication levels, which can either lead to more side effects or make medications not work as well. You might need a dose adjustment or need to switch your medications altogether.

          • If you take antacids containing aluminum and magnesium, make sure to take the antacid at least 2 hours after taking Roszet (rosuvastatin / ezetimibe). This is to make sure all of the medication gets absorbed into your body.

            • You should get your LDL bloodwork regularly checked to make sure that Roszet (rosuvastatin / ezetimibe) is working. Your provider will help you schedule those appointments when needed.

              faqs

              Frequently asked questions about Roszet (rosuvastatin / ezetimibe)

              What's the difference between Roszet (rosuvastatin / ezetimibe) and Vytorin (ezetimibe / simvastatin)?
              Both medications contain a statin in combination with ezetimibe. The major difference is that rosuvastatin in Roszet (rosuvastatin / ezetimibe) is considered a moderate-to-high-intensity statin whereas simvastatin in Vytorin is considered a low-to-medium intensity statin. The intensity of each statin depends on the dose and represents how much it can lower your LDL.
              Why does the dose of Roszet (rosuvastatin / ezetimibe) change for Asian people?
              Previous studies showed that Asian people who took rosuvastatin had twice the level of medication in their blood compared to Caucasian people at the same dose. This means that their risk of side effects from the medication were much higher. But, there isn't a clear explanation as to why this is, and other studies have shown this not to be true in every case. Yet to be on the safe side, it's recommended that Asian people start with 5 mg/10 mg of Roszet (rosuvastatin / ezetimibe) once a day to lower the risk of potential side effects.
              What's the best time of day to take Roszet (rosuvastatin / ezetimibe)?
              Since Roszet (rosuvastatin / ezetimibe) contains rosuvastatin and is a long-acting medication, you can take it any time during the day or at night time. Just make sure you try to take it around the same time each day to keep the level of medication in your body steady.
              Can I take Roszet (rosuvastatin / ezetimibe) with food?
              You can take Roszet (rosuvastatin / ezetimibe) with or without food. If it's hurting your stomach, try taking it with food to help. And unlike Vytorin, you don't need to avoid eating grapefruit while taking Roszet (rosuvastatin / ezetimibe). That's because Roszet (rosuvastatin / ezetimibe) contains a different statin medication (rosuvastatin) that doesn't interact with grapefruit and cause side effects.
              Can Roszet (rosuvastatin / ezetimibe) be used in pregnancy?
              No, Roszet (rosuvastatin / ezetimibe) shouldn't be used in people who are pregnant because it can cause harm to babies. But, treatment of high cholesterol isn't typically a priority during pregnancy. Still, your provider will ultimately decide if you need to continue treatment with another cholesterol-lowering medication. If you're pregnant or thinking of becoming pregnant while taking Roszet (rosuvastatin / ezetimibe), ask your provider about the safest options for you and your unborn baby.
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              What are the risks and warnings for Roszet (rosuvastatin / ezetimibe)?

              Roszet (rosuvastatin / ezetimibe) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

              risk-warning

              Severe muscle pain and damage

              • Risk factors: Older age | Higher dose of Roszet (rosuvastatin / ezetimibe) | Kidney problems | Taking other medications that can also cause muscle problems or interact with Roszet (rosuvastatin / ezetimibe) | History of uncontrolled hypothyroidism | Asian descent

                Roszet (rosuvastatin / ezetimibe) can cause a rare, but serious and life-threatening muscle problem called rhabdomyolysis. Symptoms include severe muscle pain, dark-colored urine, weakness, and tiredness. Don't start any new medications without asking your provider or pharmacist first because taking Roszet (rosuvastatin / ezetimibe) with certain medications raises your risk for rhabdomyolysis. If you notice any of symptoms of rhabdomyolysis, especially after starting Roszet (rosuvastatin / ezetimibe), get medical attention right away.

                risk-warning

                Worsening liver problems and liver failure

                • Risk factors: History of liver problems | Drinking large amounts of alcohol

                  Roszet (rosuvastatin / ezetimibe) can cause serious liver problems that can lead to liver failure. You'll need to get blood tests to check your liver health before and during treatment to make sure their liver is working properly. Get medical attention right away if you notice swelling of your stomach, stomach pain, yellowing of your skin or the whites of your eyes, stool changes (black, tarry, or bloody stools), nausea, vomiting, confusion, or dark or brown urine. You might need to stop using the medication to prevent further liver damage.

                  risk-warning

                  High blood sugars

                  • Risk factors: History of type 2 diabetes

                    Roszet (rosuvastatin / ezetimibe) can cause your blood sugars to be high, which can lead to high hemoglobin A1C levels, a test that represents your average blood sugar over 3 months and is used to diagnose type 2 diabetes. Let your provider know if you have diabetes before starting Roszet (rosuvastatin / ezetimibe) because you might need to monitor your blood sugar more often. Also, make sure to have a healthy, balanced diet and regular exercise while taking Roszet (rosuvastatin / ezetimibe).

                    dosage

                    Roszet (rosuvastatin / ezetimibe) dosage forms

                    The average cost for 90 tablets of 20mg/10mg of Roszet (rosuvastatin / ezetimibe) is $754.26 with a free GoodRx coupon. This is 16.28% off the average retail price of $900.92.
                    tablet
                    Tablet
                    DosageQuantityPrice as low asPrice per unit
                    5mg/10mg30 tablets$256.26$8.54
                    10mg/10mg30 tablets$256.26$8.54
                    20mg/10mg90 tablets$754.26$8.38
                    40mg/10mg90 tablets$754.26$8.38

                    Typical dosing for Roszet (rosuvastatin / ezetimibe)

                    The typical dose ranges from 5 mg/10 mg to 40 mg/10 mg of (rosuvastatin / ezetimibe) by mouth once a day.

                    Your dose of Roszet (rosuvastatin / ezetimibe) will depend on many things, including what you're taking the medication for, your LDL levels, your risk for severe heart problems, if you're of Asian descent, if you have kidney problems, or if you're taking other medications that interact with Roszet (rosuvastatin / ezetimibe).

                    drug-cost

                    How much does Roszet (rosuvastatin / ezetimibe) cost?

                    To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
                    Roszet (brand)
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                    $256.26

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                    Roszet (rosuvastatin / ezetimibe) (generic)
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                    $256.26

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                    contraindications-icon

                    Roszet (rosuvastatin / ezetimibe) contraindications

                    Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Roszet (rosuvastatin / ezetimibe) will not be safe for you to take.

                    • Advanced liver problems

                    • Severe allergy to either rosuvastatin or ezetimibe

                    alternatives

                    What are alternatives to Roszet (rosuvastatin / ezetimibe)?

                    There are a number of medications that your doctor can prescribe in place of Roszet (rosuvastatin / ezetimibe). Compare a few possible alternatives below.
                    Roszet (rosuvastatin / ezetimibe)
                    Used for:
                    $256.26 Lowest GoodRx priceView Prices
                    Vytorin (ezetimibe / simvastatin)
                    Used for:
                    $44.31 Lowest GoodRx priceView Prices
                    Nexlizet (bempedoic acid / ezetimibe)
                    Used for:
                    $389.94 Lowest GoodRx priceView Prices

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