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isoxsuprine

Generic Vasodilan (brand no longer available)
Used for Raynaud's Phenomenon, Peripheral Artery Disease
Used for Raynaud's Phenomenon, Peripheral Artery Disease

Isoxsuprine is an oral medication that's used to improve blood flow to certain parts of the body. It's no longer available in the United States because it was discontinued.

Reviewed by:
reviewer
Robert Chad Hakim, PharmD, BCCCP
reviewer
Kristianne Hannemann, PharmD
Last reviewed on January 4, 2023
BasicsFAQsInteractionsAlternativesReferencesPricesMedicare
basics-icon

What is Isoxsuprine?

What is Isoxsuprine used for?

How Isoxsuprine works

Drug Facts

Common BrandsVasodilan (brand no longer available)
Drug ClassVasodilator
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
faqs

Frequently asked questions about Isoxsuprine

What is isoxsuprine?
Isoxsuprine is a vasodilator. It works to improve blood flow by opening up the blood vessels. It can be used to treat peripheral vascular disease, such as Buerger's disease and Raynaud's disease. Isoxsuprine also helps to treat people with low blood flow to the brain (cerebrovascular insufficiency).
Is isoxsuprine still available?
No, isoxsuprine has been discontinued as of August 2021 and is no longer available in the United States.
Why was isoxsuprine discontinued?
Isoxsuprine was discontinued because the FDA determined there wasn't enough evidence to support its use, so it wasn't clear how well isoxsuprine works.
What medications are used in place of isoxsuprine?
There are other options available that can be used to improve blood flow to the body, such as cilostazol (Pletal), as well as stroke risk reduction medications. Your provider can help guide you to the best treatment option for your condition.
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interactions

Interactions between Isoxsuprine and other drugs

Isoxsuprine may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Isoxsuprine. Please note that only the generic name of each medication is listed below.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

alternatives

What are alternatives to Isoxsuprine?

There are a number of medications that your doctor can prescribe in place of Isoxsuprine. Compare a few possible alternatives below.
Isoxsuprine
Used for:
View Prices
Pentoxifylline ER
Used for:
$16.80 Lowest GoodRx priceView Prices
Cilostazol
Used for:
$24.00 Lowest GoodRx priceView Prices

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References

Best studies we found

American Association of Neurological Surgeons. (n.d.). Cerebrovascular disease.

Becker, C. (2021). Cease distribution letter - Isoxsuprine hydrochloride tablets, USP, 10 and 20 mg. U.S. Food and Drug Administration.

Gul, F., et al. (2023). Peripheral vascular disease. StatPearls.

View All References (3)

National Organization for Rare Diseases. (2007). Buerger’s disease.

Syntho Pharmaceuticals Inc.. (2014). ISOXSUPRINE HYDROCHLORIDE- isoxsuprine hydrochloride tablet [package insert]. DailyMed.

U.S. Food and Drug Administration. (2021). FDA notification regarding isoxsuprine hydrochloride drug products.

GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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