Famciclovir is an antiviral medication used for the treatment of cold sores, genital herpes, and shingles. It works best if it's taken at the first sign of an outbreak.
Cold sores (herpes labialis)
Genital herpes
Shingles (herpes zoster)
Famciclovir is converted in the body to an active, antiviral medication called penciclovir. Penciclovir prevents the herpes simplex virus (HSV) and varicella-zoster virus (VZV) from making copies of itself, which helps treat viral herpes outbreaks.
Source: DailyMed
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Incidence not known
Black, tarry stools
bleeding gums
blistering, peeling, or loosening of the skin
blood in urine or stools
chills
clay-colored stools
dark urine
dizziness
joint or muscle pain
loss of appetite
pinpoint red spots on the skin
red, irritated eyes
sores, ulcers, or white spots in the mouth or on the lips
unpleasant breath odor
unusual bleeding or bruising
vomiting of blood
yellow eyes or skin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
Bloated, full feeling
burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feeling
confusion as to time, place, or person
excess air or gas in the stomach or intestines
hives or welts
holding false beliefs that cannot be changed by fact
itching skin
mood or mental changes
passing gas
rash
redness of skin
seeing, hearing, or feeling things that are not there
unusual excitement, nervousness, or restlessness
unusual tiredness or weakness
vomiting
Incidence not known
Sleepiness or unusual drowsiness
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Can be taken with or without food
Only needs to be taken for one day to treat cold sores and genital herpes in adults without HIV
Works well for most people to shorten the duration of herpes outbreaks
Available as a generic, which can be more affordable
Not a cure for HSV and VZV infections; only controls the outbreak
Needs to be taken at the first sign of an outbreak
Unknown if taking famciclovir can lower your risk of transmitting HSV to someone else
Can't be used in people younger than 18 years of age
Famciclovir works best if it's started at the first sign of an outbreak. For people taking it for recurring herpes outbreaks, it can be helpful to have a prescription available at the pharmacy or a course of medication at home.
Famciclovir should be started within 72 hours of the first appearance of a shingles-related rash.
Famciclovir isn't a cure for viral infections, but it can help control infection breakouts and shorten healing time. Continue to follow safe sex practices like using condoms.
Talk to your healthcare provider if you have an outbreak while you're pregnant or think you may be pregnant. They will instruct you on the best treatment options.
Famciclovir can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Risk factors: History of kidney damage
Worsening kidney problems have happened in people taking famciclovir who currently have or have had kidney problems. If you have a history of kidney problems, your provider will likely lower your dose of famciclovir to prevent further kidney damage. Make sure you get your blood labs drawn regularly so your provider can monitor how well your kidneys are working.
Risk factors: Allergy or intolerance to lactose
Famciclovir tablets contain lactose. Tell your provider before starting this medication if you have a severe allergy or intolerance to lactose. If you experience shortness of breath, difficulty breathing, rash, or swelling of your face, lips, or throat, get medical help right away.
Cold sores: The typical dose is 1,500 mg by mouth for one dose.
Genital herpes: The typical dose is 1 gram by mouth twice daily for 1 day. To keep genital herpes from coming back (suppressive therapy), the dose is 250 mg twice daily.
Cold sores or genital herpes in adults with HIV: The typical dose is 500 mg by mouth twice daily for 7 days.
Shingles: The typical dose is 500 mg by mouth every 8 hours (3 times daily) for 7 days.
Your dose may differ if you have kidney problems. Ask your provider to see what dose is right for you.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Allergy to Denavir (penciclovir) cream
Cold sores (herpes labialis)
Genital herpes
Shingles (herpes zoster)
Chickenpox (varicella) in children ages 2 to 17 years old
Cold sores in people age 12 years and older
Genital herpes in adults
Shingles (herpes zoster) in adults
Oral capsule, tablet, and suspension:
Buccal tablet (Sitavig):
Ointment:
Cream
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