11 Medications That May Be Affecting Your Sex Life

Taking care of your health is worthwhile. Your sexual health is no different. 

In the U.S., over 40% of women and around 50% of men report having sexual problems. To live your most meaningful life, it’s important to understand factors that may lead to these problems. But did you know there is a link between certain medications and sexual health?

In this article, we’ll cover 11 medications that can cause sexual issues and discuss what you can do about it.

What is sexual dysfunction?

Sexual dysfunction is a term that describes a wide range of sexual problems. Specific difficulties are often divided by sex.

Men may experience erectile dysfunction (ED) or low testosterone. They may also have problems ejaculating, including ejaculating too early or more slowly than desired. Some sexual problems experienced by women include problems with arousal, trouble having orgasms, and pain during sex. 

One type of sexual dysfunction — low sexual desire (low libido) — can happen in both men and women.

What causes sexual dysfunction?

There are many potential causes of sexual dysfunction. These can be mental and/or physical and include:

• Medical conditions, such as diabetes or high blood pressure

• Hormonal changes during pregnancy, after childbirth, or while breastfeeding

• Sexually transmitted infections

• Alcohol or substance use

• Depression

• Menopause

• Relationship problems 

• Boredom with your sex life

• Older age

Medications are another common cause of sexual dysfunction. Here are the most common groups of medications that may affect your sexual health.

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1. Some antidepressants

Antidepressants are a broad group of medications. They treat mental health conditions like depression and anxiety. One common group of antidepressants are selective serotonin reuptake inhibitors (SSRIs).

Of the SSRIs, paroxetine (Paxil) is most likely to cause sexual problems. Others in this group, such as fluvoxamine (Luvox), sertraline (Zoloft), and fluoxetine (Prozac), may also be more likely to cause issues. One of the most common sexual side effects from SSRIs is delayed ejaculation.

Sexual dysfunction is less likely with other antidepressants, including mirtazapine (Remeron) and bupropion (Wellbutrin SR, Wellbutrin XL). These may be better options for people who experience sexual problems while taking antidepressants.

2. Heart failure medications

Many people with heart failure report having sexual problems. About 10% of them say that their medications are a root cause. Reported issues include ED and decreased libido.

Heart failure medications that can cause sexual problems include: 

• Digoxin (Lanoxin)

• Spironolactone (Aldactone)

• Some beta blockers

• Thiazide diuretics, such as hydrochlorothiazide (Microzide)

3. Blood pressure medications

Many high blood pressure medications can cause sexual side effects, such as low desire for sex, ED, and delayed orgasm. Some examples include clonidine (Catapres, Catapres-TTS) and methyldopa. 

Some heart failure medications can also treat high blood pressure. These include beta blockers, spironolactone, and thiazide diuretics. As mentioned above, these can all cause sexual problems. In addition to sexual issues, spironolactone may also lead to gynecomastia — enlarged breasts in men.

4. H2 blockers

Histamine-2 antagonists (H2 blockers) are common over-the-counter medications for heartburn and gastroesophageal reflux disease (GERD). Common H2 blockers include cimetidine (Tagamet HB) and famotidine (Pepcid AC).

H2 blockers are sometimes associated with sexual problems — especially in men. They can cause low desire for sex and difficulty getting an erection. 

5. Certain cancer treatments

Chemotherapy medications kill cancer cells. But they may also affect other cells in the body. Sometimes the affected cells are responsible for sexual function. 

Chemotherapy medications have the potential to cause sexual problems in men and women. Other cancer treatments, such as radiation and hormone therapy, can also cause sexual dysfunction.

6. Medications that affect sex hormones

Medications that affect sex hormone levels can cause sexual problems. Sex hormones include estrogen, testosterone, and progesterone. These medications can cause symptoms such as ED and decreased libido.

Examples of these medications include:

• Gonadotropin releasing hormone (GnRH) agonists, such as leuprolide (Lupron Depot, Eligard)

• GnRH antagonists, such as elagolix (Orlissa)

• Androgen receptor inhibitors, such as bicalutamide (Casodex)

• Birth control products

It’s not completely clear how birth control affects sexual function. Some research suggests that they decrease sex hormone levels, which can lead to sexual problems. But other studies suggest that some birth control pills are less likely to cause sexual problems than others. These include:

• Estradiol valerate and dienogest (Natazia)

• Ethinyl estradiol and levonorgestrel (Vienva, Alesse, Aviane)

• Ethinyl estradiol and drospirenone (Yasmin, Ocella, Zarah)

7. Antipsychotics

Antipsychotic medications treat various mental health conditions, including schizophrenia and bipolar disorder. They may cause sexual problems by changing the levels of certain chemicals in the body, including dopamine and prolactin. 

The antipsychotics that are most likely to cause sexual problems are typical (first-generation) antipsychotics, like haloperidol (Haldol). Atypical (second-generation) antipsychotics are less likely to cause sexual problems. Risperidone (Risperdal) is the exception. This medication is more likely than other atypical antipsychotics to cause sexual dysfunction. 

8. Opioids

Opioids can treat short-term and chronic pain. Common opioid medications include tramadol (Qdolo, ConZip), oxycodone (OxyContin), and hydrocodone / acetaminophen.

In general, many people with chronic pain experience sexual problems. And pain medications like opioids can lower sexual desire in their own right. They may also make ED more likely. 

Medications used to treat opioid use disorder can also cause sexual dysfunction. These include methadone (Methadose), buprenorphine (Suboclade), and buprenorphine / naloxone (Suboxone, Zubsolv).

9. Benzodiazepines

Benzodiazepines treat conditions such as anxiety, panic disorder, and epilepsy (seizure disorder). However, these medications may contribute to decreased libido and a lowered ability to orgasm, among other issues. It’s important to note that having anxiety can cause sexual problems too, though.

Common benzodiazepines include alprazolam (Xanax), lorazepam (Ativan), and diazepam (Valium).

10. Statins

Statins help treat high cholesterol. They may also cause sexual problems because they can potentially lower testosterone. However, the research is conflicting. Some studies suggest that statin use isn’t actually associated with sexual dysfunction.

Talk to a healthcare professional if you’re experiencing sexual problems with statins. But know that statins lower the risk of heart attack and stroke. So don’t stop taking them without talking to a healthcare professional first. 

11. Antiepileptics

Antiepileptics, sometimes called anticonvulsants, treat a wide variety of health conditions. They’re commonly used to prevent seizures in people with epilepsy, and they also treat some types of nerve pain. However, antiepileptics can also cause or contribute to sexual dysfunction.

There are several anticonvulsants that may cause sexual problems. They include carbamazepine (Tegretol), valproic acid (Depakene), and phenytoin (Dilantin). Levetiracetam (Keppra) may cause less sexual side effects than other antiepileptics.

How to improve sexual dysfunction caused by medications

If you develop sexual problems, talk to a healthcare professional. They can help you figure out if it’s due to any of your medications or if there’s another cause. 

If medication is the culprit, there are a few things you can do.

Your healthcare professional may recommend stopping the medication if it’s not necessary. Or they may recommend switching to another medication that’s less likely to cause issues. Always talk to your healthcare professional before stopping a medication or trying a new one.

If stopping or switching your medication isn’t an option, your healthcare professional may prescribe another medication to help address sexual side effects. For example, phosphodiesterase type 5 (PDE5) inhibitors such as sildenafil (Viagra) and tadalafil (Cialis) can treat ED in men. And some medications, such as Addyi (flibanserin) and Vyleesi (bremelanotide), can help with low sex drive in women.

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Written by:

Nathan Williams, PharmD, RYT

Nathan is a clinical pharmacist, certified yoga instructor, and medical content writer. His clinical practice has spanned several sub-specialties including: emergency medicine, nutrition, and pediatrics.

Edited by:

Joshua Murdock, PharmD, BCBBS

Joshua Murdock, PharmD, BCBBS, is a licensed pharmacist in Arizona, Colorado, and Rhode Island. He has worked in the pharmacy industry for more than 10 years and currently serves as a pharmacy editor for GoodRx.

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