Contrave (naltrexone/bupropion) is used to promote and maintain weight loss in obese adults or overweight adults who have weight related medical problems. Contrave is a opioid antagonist/atypical antidepressant combination drug, which works by effecting parts of your brain that are responsible for appetite control and the reward system. Contrave is available as an 8mg/90mg tablet. There are currently no generic alternatives to Contrave. It is covered by most Medicare and insurance plans.

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