Skip to main content
HomeDrug Comparisons
Drug bottle and Pill

Compare Vtama vs. Zoryve

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Vtama (tapinarof)
    Zoryve (roflumilast)
  • Vtama (tapinarof)
    Zoryve (roflumilast)

  • Summary of Vtama vs. Zoryve

    Summary for Aryl hydrocarbon receptor agonist
    Prescription only

    Vtama (tapinarof) is a topical cream that's used to treat plaque psoriasis in adults. It can also treat eczema (atopic dermatitis) in people 2 years of age and older. Unlike other topical treatments for skin conditions, Vtama (tapinarof) isn't a steroid. Instead, it's an aryl hydrocarbon receptor (AhR) agonist. It's thought to boost the activity of AhR, leading to less inflammation in the skin cells and healthier skin. Vtama (tapinarof) is applied to the affected areas once daily. But it can cause side effects on the skin like irritated hair follicles or a rash.

    Summary for PDE4 inhibitor
    Prescription only

    Zoryve (roflumilast) is a cream and foam that's approved for treating certain skin conditions in adults and children. Both can be used for plaque psoriasis. The cream is also used for atopic dermatitis (eczema), and the foam can also be used for seborrheic dermatitis. Zoryve (roflumilast) is a phosphodiesterase 4 (PDE4) inhibitor. It works to lessen inflammation on the skin. You apply Zoryve (roflumilast) to the affected area(s) of the skin once a day. Side effects can include headache and nausea.

  • Indications of Vtama vs. Zoryve

    Indications for
    •Plaque psoriasis in adults
    •Eczema in adults and children age 2 and older
    Indications for
    •

    Zoryve (roflumilast) cream

    •Plaque psoriasis in people 6 years and older - 0.3% cream
    •Mild-to-moderate eczema in people 6 years and older - 0.15% cream
    •Mild-to-moderate eczema in children 2 to 5 years old - 0.05% cream
    •

    Zoryve (roflumilast) 0.3% foam

    •Plaque psoriasis on the scalp and body in people 12 years and older
    •Seborrheic dermatitis in people 9 years and older

  • Pros and Cons of Vtama vs. Zoryve

    Pros and Const for Aryl hydrocarbon receptor agonist
    Pros
    •Only applied onto the affected areas once daily
    •Can apply to sensitive areas, including the face and skin folds
    •A different kind of medication that isn't a steroid
    Cons
    •Can cause side effects on the skin, like red bumps and itchy rash
    •Not FDA approved for all types of inflammatory skin conditions
    •Not known whether it's safe to use during pregnancy or while breastfeeding
    Pros and Const for PDE4 inhibitor
    Pros
    •Steroid-free topical medication
    •Only applied once a day
    •Few side effects
    •Generally safe to use for a long time
    Cons
    •Cream not approved for children under 2 years old with eczema
    •Foam not approved for children under 9 years old with seborrheic dermatitis
    •Not safe for people with moderate or severe liver conditions
    •Not known if it's safe to use during pregnancy or while breastfeeding

  • Common Side Effects of Vtama vs. Zoryve

    Common Side Effects for

    Plaque psoriasis:

    •Red, raised bumps around the hair pores (20%)
    •Symptoms of the common cold (11%)
    •Rash (7%)

    Eczema:

    •Upper respiratory tract infection (12%)
    •Red, raised bumps around the hair pores (9%)
    •Lower respiratory tract infection (5%)
    Common Side Effects for

    Zoryve (roflumilast) 0.05% cream:

    •Upper respiratory tract infection (4%)
    •Diarrhea (3%)
    •Vomiting (2%)
    •Runny nose (2%)

    Zoryve (roflumilast) 0.15% cream:

    •Headache (3%)
    •Nausea (2%)

    Zoryve (roflumilast) 0.30% cream:

    •Diarrhea (3%)
    •Headache (2%)

    Zoryve (roflumilast) 0.30% foam:

    •Headache (3%)
    •Diarrhea (3%)
    •Nausea (2%)

  • Warnings of Vtama vs. Zoryve

    Common Side Effects for
    Common Side Effects for
    •Flammable (foam only)

  • Prices with our coupons for Vtama vs. Zoryve

    Learn more about Vtama
    Learn more about Zoryve

Compare other Plaque Psoriasis drugs

Vtama vs Zoryve

Browse medications

View All

Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.