Ammonium lactate is a medication that's used to treat dry, scaly, and itchy skin. It comes in lotions and creams that you rub onto your skin twice daily. This medication has few side effects, including rash, burning, or stinging, and it can make it easier for you to get sunburns. Ammonium lactate is available as a lower-cost generic by prescription, but you can also find it over-the-counter as AmLactin brand-name products.
Dry, itchy, or scaly skin
Ammonium lactate is an alpha-hydroxy acid (AHA). Experts don't know exactly how ammonium lactate relieves dry and itchy skin. But it's thought to help boost healthy skin renewal through gentle skin exfoliation. It also appears to help keep the skin moisturized.
Source: DailyMed
Side effects that you should report to your care team as soon as possible:
Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
Mildly exfoliates to help remove dry, flaky, or scaly skin
Can use prescription versions for children as young as 2 years old
Also available over-the-counter
Can cause you to sunburn easier
Might not be a good option to use on your face because of risk of stinging near sensitive areas and risk of sunburn
Might take a few weeks of everyday use to notice improvement in skin texture
Wash your hands before and after applying ammonium lactate. If you're using the lotion version of this medication, shake the bottle well before each time you apply it onto your skin.
You might feel stinging or burning after you apply ammonium lactate to your skin, but it should go away after a while. This is more likely to happen if you use the medication on skin that's cut, scraped, or freshly shaven. Talk to your provider if these side effects become intolerable.
Be careful if you apply ammonium lactate onto your face. Avoid getting the medication near or in your eyes, lips, mouth, or nose because doing so can cause irritation.
Ammonium lactate can make your skin more sensitive to the sun, which means you might sunburn more easily. This can happen even during the winter and on overcast days. Make sure to avoid sun exposure to the areas where you applied the medication, wear protective clothing and a wide-brimmed hat, and use a moisturizing sunscreen with an SPF of at least 30 while you're using ammonium lactate.
Ammonium lactate works best when you use it every day. Let your provider know if you notice that your skin condition hasn't improved or has worsened after a few weeks of using this medication. You might need a different medication to help with your skin.
Other things you can do to help with dry skin while you're using ammonium lactate include staying hydrated and avoiding hot water and harsh skin products (e.g., soaps, hand sanitizers). Ask your pharmacist for recommendations on non-irritating, mild cleansers to use.
Ammonium lactate can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Ammonium lactate can make your skin more sensitive to sunlight, which can make it easier for you to get sunburns. Try to avoid sun exposure to the areas of skin where you applied ammonium lactate. Make sure to wear protective clothing and use a sunscreen with an SPF of at least 30 when you go outside, even on overcast days and during the winter.
Ammonium lactate is intended to be used on the skin only. Keep it out of your mouth, nose, eyes, and genitals. Rinse well with water if you accidentally get the medication in any of these areas.
Hyperkeratosis (abnormally thick or tough skin or nails)
Dry skin
Relief of burning and itching from skin conditions, such as eczema
Wound healing
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Advantice Health, LLC. (n.d.). Frequently asked questions.
Algiert-Zielińska, B., et al. (2019). Lactic and lactobionic acids as typically moisturizing compounds. International Journal of Dermatology.
Ademola, J., et al. (2002). Clinical evaluation of 40% urea and 12% ammonium lactate in the treatment of xerosis. American Journal of Clinical Dermatology.
Kornhauser, A., et al. (2010). Applications of hydroxy acids: Classification, mechanisms, and photoactivity. Clinical, Cosmetic and Investigational Dermatology.
Moghimipour, E. (2012). Hydroxy acids, the most widely used anti-aging agents. Jundishapur Journal of Natural Pharmaceutical Products.
Padagis Israel Pharmaceuticals Ltd. (2022). Ammonium lactate lotion [package insert]. DailyMed.
Taro Pharmaceuticals U.S.A., Inc. (2022). Ammonium lactate cream [package insert]. DailyMed.
U.S. Food and Drug Administration. (2018). Guidance for industry: Labeling for cosmetics containing alpha hydroxy acids.
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